A5024328077- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Prostate Cancer Treatment and Research
- Prenatal Substance Exposure Effects
- Cancer Risks and Factors
- Immunotherapy and Immune Responses
- Global Cancer Incidence and Screening
- Neuroscience of respiration and sleep
- Prostate Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Maternal Mental Health During Pregnancy and Postpartum
- Histone Deacetylase Inhibitors Research
- Nausea and vomiting management
- Cancer Treatment and Pharmacology
- Nutritional Studies and Diet
- Advanced Breast Cancer Therapies
- Land Use and Ecosystem Services
- Biomedical Ethics and Regulation
- Dental Health and Care Utilization
- Pharmaceutical Practices and Patient Outcomes
- Advances in Oncology and Radiotherapy
- Dental Anxiety and Anesthesia Techniques
- MicroRNA in disease regulation
- Homelessness and Social Issues
- Multiple Myeloma Research and Treatments
Thomas Jefferson University
2018-2025
Sidney Kimmel Comprehensive Cancer Center
2024-2025
Sidney Kimmel Cancer Center
2019-2024
Thomas Jefferson University Hospital
2021-2024
Columbia University
2020
Boston University
2018
<h3>Importance</h3> Immune checkpoint inhibitors (ICIs) have revolutionized melanoma treatment and are now standard of care. Although sex is associated with immune function immune-related diseases, the interaction between ICIs understudied. <h3>Objective</h3> To examine whether cancer immunotherapy effectiveness varies female male patients advanced treated either nivolumab plus ipilimumab combination therapy or anti–programmed cell death protein 1 (PD-1) (namely, pembrolizumab nivolumab)....
Prostate cancer is an important cause of death worldwide. The number years life lost (YLL) due to prostate a metric the toll and using projections demographic changes, can be used measure future burden.
Neonatal abstinence syndrome (NAS) due to in-utero opioid exposure has significant variability of severity. Preliminary studies have suggested that epigenetic variation within the μ-opioid receptor (OPRM1) gene impacts NAS. We aimed determine if DNA methylation in OPRM1 opioid-exposed mother-infant dyads is associated with differences NAS severity an independent cohort. Full-term newborns and their mothers (N = 68 pairs) were studied. A sample was obtained then assessed for level at 20 CpG...
Immune checkpoint inhibitors (ICIs) harness the immune system and are therapy of choice for multiple cancers. Although immunosuppressive agents such as steroids also used in many cancers, it is unknown how their timing affects treatment outcomes. Thus, we investigated relationship between steroid exposure preceding ICI administration subsequent outcomes melanoma. This population-based study utilized SEER-Medicare-linked database to identify patients diagnosed with melanoma 1991 2015...
Most vernacular landscapes today are under inevitable transformations. To manage these transforming landscapes, previous research has highlighted "bottom-up planning" that integrates local knowledge and willingness into decision-making, "organizational design" manipulates the self-organizing process based on actions. However, indeterminacy exists in effectiveness of bottom-up organizational design shaping sustainability at landscape scale. Addressing this, this paper aims to explore (1)...
Abstract Background: Colorectal cancer (CRC) is the 3rd leading cause of death in US. Early detection through screening increases survival and decreases mortality. Approximately 59% eligible adults US are up to date on CRC with lower rates minoritized communities. We report a tailored educational intervention focused improving Black, Latinx, Chinese immigrant communities that we serve. Methods: An utilizing NCI’s Screen Save colorectal materials was key contact interviews focus groups made...
Abstract Background: Persons with a history of cancer are at higher risk adverse COVID-19 outcomes due to their immunosuppressed status. Vaccination has proven effective in decreasing complications from infection. This study explored the vaccination status persons receiving care (received 1st dose/2nd dose/booster) and symptoms. Methods: diagnosis center clinical site were randomly invited complete voluntary survey via email, EMR, or during an in-person appointment. Paper surveys completed...
Abstract Institutions: Thomas Jefferson University Department of Oncology Funded by: NIH/NCI 3P30CA056036-22S1 Background Clinical trials (CT) advance knowledge in cancer care. Access to CT may be facilitated by patient knowledge. We evaluated the impact a tailored educational video intervention via pre- and post-test survey on interest enrollment. Methods Participants included persons with (PwCa) as well without cancer—general population (GP). A McNemar test was used assess differences...
Abstract Introduction Immune checkpoint inhibitors (ICIs) offer substantial benefits for older adults with lung cancer (LCa) but they also pose risks of immune-related adverse events (irAEs), necessitating investigation into the demographic influences on hospitalization rates. Sex differences among within this cohort are understudied. Our study aims to explore gender in irAE-related hospitalizations adults. Methods We utilized Surveillance, Epidemiology, and End Results (SEER)-linked...
5056 Background: The safety of ARAT (Abiraterone acetate (AA) and Enzalutamide (ENZ)) among men with existing CVDs or EPP (≥10 concurrent medications) is unknown since patients these conditions are often excluded from the clinical trials. This study was undertaken to fill knowledge gaps. Methods: population-based identified PCa linked Surveillance, Epidemiology End Result-Medicare files diagnosed during 1/1/1991-12/31/2013. primary endpoint 6-month overall mortality after drug initiation....
6590 Background: Immune checkpoint inhibitors (ICIs) have rapidly become the treatment of choice for multiple cancer types. However, relationship between timing immunosuppressive agents, such as steroids use, preceding ICI initiation and subsequent outcomes remains unknown due to lack data. This study was undertaken address this knowledge gap. Methods: We used Surveillance, Epidemiology End Results (SEER)-Medicare linked data identify patients with melanoma receiving Ipilimumab, Nivolumab,...
Abstract Background: Advanced prostate cancer patients with pre-existing cardiovascular diseases (CVD) are often excluded from clinical trials of abiraterone acetate (AA). Therefore, the outcomes these uncertain. This study was undertaken to examine their - changes in rate hospitalization and short-term mortality after AA initiation by CVD conditions. Methods: population-based identified PCa linked Surveillance, Epidemiology End Result (SEER)-Medicare files diagnosed between 1/1/1991...
e19020 Background: The rate of obesity in adults is 34% the city Philadelphia, with rates being highest among non-Hispanic blacks and Hispanics. We sought to evaluate how BMI varies by age race/ethnicity at time initial encounter for a breast cancer (BC) diagnosis (dx), investigate factors predictive change first 2 years dx. Methods: identified 1,833 patients (pts) our electronic medical record, (1/2015-present), who had BC dx their hospital or ambulatory using ICD-10 code C50.X, recorded...
121 Background: It is uncertain whether the same criteria for active surveillance can be applied universally across races. This population-based study was undertaken to quantify racial differences in long-term risk of prostate cancer-specific mortality (PCSM) among patients with low-risk cancer (PCa) receiving conservative management. Methods: We used Surveillance, Epidemiology, and End Results (SEER) database identify who had PCa (T1-T2a & Gleason 6 PSA ≤ 10 ng/mL N0 M0) diagnosed 2004...
e13118 Background: Immune checkpoint inhibitors (ICIs), especially ipilimumab (ipi) and nivolumab (nivo), have received approvals from the U.S. Food Drug Administration for treatment of multiple tumor types. These medications shown great promise in several malignancies but are associated with immune-related adverse events. This study was undertaken to better understand patterns events following different ICIs. Methods: We used World Health Organization (WHO) Vigiaccess Database, largest...
9567 Background: The relationship between immunosuppressants and immunotherapy (IO) is an active area of research. Here we study the impact pre-treatment steroid use on completion ipilimumab (ipi) therapy. Methods: This population-based identified patients diagnosed with melanoma treated ipi (brand name Yervoy) in 2010-2014 from linked Surveillance, Epidemiology End Result-Medicare files. “Completion IO time” was defined as receiving 4 cycles within 90 days. Otherwise, were considered to...