A5025615311- Cancer survivorship and care
- Nutrition and Health in Aging
- Colorectal Cancer Screening and Detection
- Frailty in Older Adults
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Multiple and Secondary Primary Cancers
- Cardiac, Anesthesia and Surgical Outcomes
- Metabolism, Diabetes, and Cancer
- Colorectal Cancer Treatments and Studies
- Cancer-related cognitive impairment studies
- Tryptophan and brain disorders
- Head and Neck Cancer Studies
- Cancer Treatment and Pharmacology
- Lung Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Cardiovascular and exercise physiology
- Palliative Care and End-of-Life Issues
- Cholangiocarcinoma and Gallbladder Cancer Studies
VieCuri Medisch Centrum
2016-2025
Maastricht University
2016-2025
Maastricht University Medical Centre
2016-2023
Zuyderland Medisch Centrum
2023
Erasmus MC Cancer Institute
2016
Netherlands Comprehensive Cancer Organisation
2006-2016
The Netherlands Cancer Institute
2016
Leiden University Medical Center
2010-2016
Thales (Netherlands)
2016
Medisch Spectrum Twente
2016
Comorbidity has large impact on colorectal cancer (CRC) treatment and outcomes may increase as the population ages. We aimed to evaluate prevalence time trends of comorbid diseases in patients with CRC from 1995 2010. The Eindhoven Cancer Registry registers comorbidity all primary South Netherlands. analyzed serious four frames Thereby, we addressed its association age, gender socio-economic status (SES). was registered 27,339 CRC. During study period, increased 47% 62%, multimorbidity 20%...
Background: The primary aim of the study was to investigate prognosis and long-term survival in young breast cancer patients with a BRCA1 or BRCA2 germline mutation compared noncarriers. secondary whether differences originate from associations tumor characteristics, second cancers, and/or treatment response. Methods: We established cohort invasive diagnosed younger than age 50 years 10 Dutch hospitals between 1970 2003. BRCA1/2 testing most prevalent mutations mainly done using DNA isolate...
Bronchiolitis is a common disorder in young children that often results hospitalisation. Except for possible effect of nebulised hypertonic saline (sodium chloride), no evidence-based therapy available. This study investigated the efficacy 3% and 6% compared with 0.9% hospitalised viral bronchiolitis. In this multicentre, double-blind, randomised, controlled trial, acute bronchiolitis were randomised to receive either 3%, or normal during their entire hospital stay. Salbutamol was added...
Abstract Type 2 diabetes mellitus (T2DM) is associated with greater risk for colorectal cancer (CRC). The age of onset T2DM decreasing worldwide. An increased CRC in young patients could be relevant the at which to initiate screening. We report on attention diagnosis. used pharmacy data (from 1998 2010) from PHARMO Database Network linked Eindhoven Cancer Registry. Multivariable time-dependent Cox regression analyses were conducted calculate hazard ratios (HR) developing comparing non-T2DM....
Frailty in older patients might influence treatment decisions. can be determined using a Comprehensive Geriatric Assessment (CGA), but this is time-consuming and expensive. Therefore we assessed the diagnostic value of four shorter screening instruments.We tested abbreviated CGA (aCGA), Vulnerable Elders Survey-13 (VES-13), Groningen Indicator (GFI) 8 (G8). A full including functional status, cognitive depression, nutrition comorbidity was used as reference. minimum 85% for both sensitivity...
Prehabilitation appears to be an effective strategy reduce postoperative complications and enhance recovery after colorectal surgery. Although many patients prefer (unsupervised) home-based prehabilitation, adherence can problematic. Combining prehabilitation with tele-monitoring might demonstrate a higher than unsupervised prehabilitation; however, evidence on its feasibility effectiveness in cancer scheduled for elective surgery who are at high risk is lacking. The aim of this study was...
Background Type 2 diabetes mellitus (T2DM) is associated with an increased risk of colorectal cancer (CRC); however, studies differentiating between subsites CRC are limited. We investigated how (DM) was subsite-specific in men and women. Methods The Netherlands Cohort Study on diet a prospective study among 120 852 women aged 55–69 years old at baseline 1986. Information DM, anthropometric, dietary lifestyle factors self-reported baseline. T2DM defined as the diagnosis DM after 30 age....
An unhealthy lifestyle is associated with the risk of colorectal cancer (CRC), but it unclear whether overall after a CRC diagnosis risks recurrence and mortality. To examine associations between postdiagnosis changes in all-cause The study population included 1425 newly diagnosed, stage I–III patients from 2 prospective cohort studies enrolled 2010 2016. Lifestyle, including BMI, physical activity, diet, alcohol intake, was assessed at 6 months postdiagnosis. We assigned scores based on...
Post-treatment adherence to the World Cancer Research Fund/American Institute for (WCRF/AICR) lifestyle recommendations were associated with health-related quality of life (HRQoL), fatigue, and chemotherapy-induced peripheral neuropathy (CIPN) in colorectal cancer (CRC) survivors. In a prospective cohort among CRC survivors (
A healthy diet may help to reduce cancer-related fatigue, but evidence is limited and mechanisms remain unclear. Both fatigue following colorectal cancer (CRC) have been linked metabolites (kynurenines) of the kynurenine pathway (KP). We investigated longitudinal associations between dietary intake potential mediating role KP, in CRC survivors up 1 year post-treatment. Measurements at 6 weeks, months, post-treatment were performed 209 stage I-III survivors. Diet was assessed by 7-day food...
To identify an optimal postoperative day 3 (POD3) C-reactive protein (CRP) cut-off for predicting major complications in colorectal cancer (CRC) patients. Secondary objectives included identifying patient and surgical factors associated with POD3 CRP levels assessing the accuracy of across subgroups. A retrospective cohort study 1536 CRC patients who underwent oncological resection was conducted. The predictive tested using Receiver Operating Characteristics curves. Multivariable logistic...