A5008896423- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Beetle Biology and Toxicology Studies
- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- Sarcoma Diagnosis and Treatment
- Uterine Myomas and Treatments
- Global Cancer Incidence and Screening
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Bioinformatics and Genomic Networks
- Cervical Cancer and HPV Research
- HER2/EGFR in Cancer Research
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- PI3K/AKT/mTOR signaling in cancer
- Gene expression and cancer classification
- Reproductive Biology and Fertility
- Molecular Biology Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
Thales (Netherlands)
2016-2024
Ontwikkelingsmaatschappij Oost Nederland
2012-2024
St. Antonius Ziekenhuis
2024
Leiden University Medical Center
2016
VieCuri Medisch Centrum
2016
Erasmus MC Cancer Institute
2016
Netherlands Comprehensive Cancer Organisation
2016
The Netherlands Cancer Institute
2016
Medisch Spectrum Twente
2008-2016
Maastricht University Medical Centre
2016
Risk-assessment of endometrial cancer (EC) is based on clinicopathological factors and molecular subgroup. It unclear whether adding hormone receptor expression, L1CAM expression or CTNNB1 status yields prognostic refinement.Paraffin-embedded tumour samples women with high-risk EC (HR-EC) from the PORTEC-3 trial (n = 424), a Dutch prospective clinical cohort called MST 256), were used. All cases molecularly classified. Expression L1CAM, ER PR analysed by whole-slide immunohistochemistry...
Abstract Photoacoustic (optoacoustic) imaging can visualize vasculature deep in tissue using the high contrast of hemoglobin to light, with high-resolution possible ultrasound detection. Since angiogenesis, one hallmarks cancer, leads increased vascularity, photoacoustics holds promise breast cancer as shown proof-of-principle studies. Here for first time, we investigate if there are specific photoacoustic appearances malignancies which be related tumor an upgraded research system, Twente...
Endometrial cancer can be molecularly classified into POLEmut, mismatch repair deficient (MMRd), p53 abnormal (p53abn), and no specific molecular profile (NSMP) subgroups. We aimed to develop an interpretable deep learning pipeline for whole-slide-image-based prediction of the four classes in endometrial (im4MEC), identify morpho-molecular correlates, refine prognostication.This combined analysis included diagnostic haematoxylin eosin-stained slides clinicopathological data from 2028...
Background: The primary aim of the study was to investigate prognosis and long-term survival in young breast cancer patients with a BRCA1 or BRCA2 germline mutation compared noncarriers. secondary whether differences originate from associations tumor characteristics, second cancers, and/or treatment response. Methods: We established cohort invasive diagnosed younger than age 50 years 10 Dutch hospitals between 1970 2003. BRCA1/2 testing most prevalent mutations mainly done using DNA isolate...
<h3>Background</h3> Risk-reducing salpingectomy with delayed oophorectomy has gained interest for individuals at high risk tubo-ovarian cancer as there is compelling evidence that especially high-grade serous carcinoma originates in the fallopian tubes. Two studies have demonstrated a positive effect of on menopause-related quality life and sexual health compared standard risk-reducing salpingo-oophorectomy. <h3>Primary Objective</h3> To investigate whether non-inferior to current...
Detection of 11 pathogenic variants in the POLE gene endometrial cancer (EC) is critically important to identify women with a good prognosis and reduce overtreatment. Currently, status determined by DNA sequencing, which can be expensive, relatively time-consuming, unavailable hospitals without specialized equipment personnel. This may hamper implementation POLE-testing clinical practice. To overcome this, we developed validated rapid, low-cost hotspot test quantitative polymerase chain...
Abstract Background Breast cancer survivors are at risk for contralateral breast (CBC), with the consequent burden of further treatment and potentially less favorable prognosis. We aimed to develop validate a CBC prediction model evaluate its applicability clinical decision-making. Methods included data 132,756 invasive non-metastatic patients from 20 studies 4682 events median follow-up 8.8 years. developed multivariable Fine Gray (PredictCBC-1A) including patient, primary tumor,...
Purpose: Uterine sarcomas are rare and heterogeneous tumors characterized by an aggressive clinical behavior. Their high rates of recurrence mortality point to the urgent need for novel targeted therapies alternative treatment strategies. However, no molecular prognostic or predictive biomarkers available so far guide choice modality treatment.Experimental Design: We investigated expression several druggable targets (phospho-S6S240 ribosomal protein, PTEN, PDGFR-α, ERBB2, EGFR) in a large...
Abstract Background Primary tumour biology and axillary lymph node status are key prognostic factors in breast cancer treatment. The LowMag trial introduced a magnetic sentinel biopsy procedure using superparamagnetic iron oxide (SPIO) tracer handheld magnetometer as radiation-free alternative for staging. aimed to assess low-dose non-invasive preoperative evaluation of metastases intraoperative detection. Methods Patients with confirmed invasive or ductal carcinoma situ, eligible biopsy,...
To investigate the issue of timing radiation therapy (RT) after lumpectomy in relation to recurrences and outcome. Analysis was done on 1107 breast-conserving therapies (BCT) with 1070 women, all without lymph node metastasis any adjuvant systemic therapy. Timing defined as time from till RT. Patients were categorised into tertiles: <45 days, 45–56 57–112 days. Local control did not show a difference between tertiles. The distant metastasis-free survival well disease-specific showed...
Seventeen previously untreated children with Hodgkin's disease were treated six courses of the combination adriamycin, bleomycin, vinblastine, and DTIC (ABVD), without radiotherapy, from 1984-1987. In all patients, complete remission was attained. After a median follow-up period 73.5 months (range 59-98 months) five patients had relapse after 4, 5, 11, 21, 34 months, respectively, attainment remission. 12 stages I II, two relapses occurred. Three out stage III IV developed relapse. Based...
Patients with advanced triple-negative breast cancer (TNBC) benefit from treatment atezolizumab, provided that the tumor contains ≥1% of PD-L1/SP142-positive immune cells. Numbers tumor-infiltrating lymphocytes (TILs) vary strongly according to anatomic localization TNBC metastases. We investigated inter-pathologist agreement in assessment PD-L1/SP142 immunohistochemistry and TILs. Ten pathologists evaluated expression a proficiency test comprising 28 primary TNBCs, as well levels TILs 49...
Abstract In recent years, it has become clear that artificial intelligence (AI) models can achieve high accuracy in specific pathology‐related tasks. An example is our deep‐learning model, designed to automatically detect serous tubal intraepithelial carcinoma (STIC), the precursor lesion high‐grade ovarian carcinoma, found fallopian tube. However, standalone performance of a model insufficient determine its value diagnostic setting. To evaluate impact use this on pathologists' performance,...
Mean nuclear area has been consistently shown by different researchers to be a strong and independent prognostic factor in advanced ovarian carcinoma. However, the biological background of value remains unclear. Others have found that multidrug‐resistance (MDR) related protein LRP value. In present study we analysed whether mean are tumour tissue ovary obtained at debulking operation before administration chemotherapy 40 patients. The mitotic activity index, volume percentage epithelium,...
AIMS: To evaluate correlations among clinical, pathological, morphometric, stereological, and DNA flow cytometric variables their prognostic value in advanced ovarian cancer. METHODS: Tissue was collected from 180 patients with All had undergone debulking surgery were being treated cisplatin. Long term follow up available for all patients. The mitotic activity index (MAI), volume % of epithelium (VPE), mean nuclear area (MNA), standard deviation the (SDNA), estimates weighted (nu v),...
Background. The aim of this study is to analyze the impact first degree relative (FDR) young breast cancer patients.Methods. Data were used from our prospective population-based cohort which started in 1983. family history (FH) was registered with regard FDR: presence or absence invasive none vs. one more FDRs at any age.Results. A total 1109 women, ≤50 years 1128 conserving treatments seen. incidence FDR 17.0% for and 3.2% ≥2 FDR. three groups, none, 1 FDR, comparable. local failure rate...
Abstract To study factors that possibly influence the heterogeneous tumor uptake of radiolabeled antibodies, tissues from 34 ovarian‐carcinoma patients were obtained 2 to 8 days after i.v. injection with murine OV‐TL 3 or chimeric MOv 18 (cMOv18). The and ratio normal tissue (T/NT) studied in relation histopathological classification, prior treatment, site tumor, time interval, antigen expression, volume percentage (malignant) epithelium tissue, size tumor. results immuno‐scintigraphy also...