A5041477572- Glioma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Endometrial and Cervical Cancer Treatments
- AI in cancer detection
- Soft tissue tumor case studies
- Chromatin Remodeling and Cancer
- MicroRNA in disease regulation
- Ion channel regulation and function
- Cervical Cancer and HPV Research
- Cancer, Hypoxia, and Metabolism
- Renal and related cancers
- Vascular Tumors and Angiosarcomas
- Occupational and environmental lung diseases
- Artificial Intelligence in Healthcare and Education
- Meningioma and schwannoma management
- Cancer Mechanisms and Therapy
- Soft tissue tumors and treatment
- Telomeres, Telomerase, and Senescence
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Brain Metastases and Treatment
- Neurofibromatosis and Schwannoma Cases
- BRCA gene mutations in cancer
- Medical Imaging and Pathology Studies
University of Padua
2021-2024
Azienda Ospedaliera di Padova
2023
Istituto Oncologico Veneto
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2023
University of Florence
2017-2021
Azienda ULSS 9 TREVISO
2020-2021
Ca' Foncello Hospital
2018-2020
University of Perugia
2013-2014
Endocrinology Research Center
2007
Platinum-based drugs such as Cisplatin are commonly employed for cancer treatment. Despite an initial therapeutic response, treatment often results in the development of chemoresistance. To identify novel approaches to overcome resistance, we tested combination with K+ channel modulators on colorectal (CRC) cells.The functional expression Ca2+-activated (KCa3.1, also known KCNN4) and voltage-dependent (Kv11.1, KCNH2 or hERG1) channels was determined two CRC cell lines (HCT-116 HCT-8) by...
Nowadays pathology laboratories are worldwide facing a digital revolution, with an increasing number of institutions adopting (DP) and whole slide imaging solutions. Despite indeed providing novel helpful advantages, embracing DP workflow is still challenging, especially for wide healthcare networks. The Azienda Zero the Veneto Italian region has begun process fully transformation integrated network 12 hospitals producing nearly 3 million slides per year. In present article, we describe...
A type of breast tumor histopathologically similar to the papillary thyroid carcinoma has been described and named “Breast resembling tall cell variant carcinoma.” Because is not an uncommon site for metastasis about 5% all such cases are origin, it important be aware existence mammary tumors that can closely mimic a representing dangerous diagnostic pitfall also lead unnecessary clinical investigations. Here, we describe singular case carcinoma” showing amazing macroscopic microscopic...
Abstract The definition of the gene expression profile genes encoding Ion Channels and Transporters (ICT-GEP) represents a novel attracting aspect in cancer. We determined ICT-GEP Follicular Lymphoma (FL), compared it with that more aggressive Diffuse Large B Cell (DLBCL). cDNA microarray data were collected both from patients enrolled for this study, public datasets. In FL indicated overexpression K + channel KCNN4 , SLC2A1 which encodes Glut1 glucose transporter. turned out to represent...
Objective: The present study aimed to assess long-term follow-up outcomes in women with situ/microinvasive adenocarcinoma (AC) of the uterine cervix treated conservatively. Methods: Retrospective multi-institutional including early glandular lesions and 5-year undergoing fertility-sparing treatment. Independent variables associated recurrence were evaluated. Logistic regression analysis Kaplan–Meier survival Logrank test performed. Results: Of 269 diagnosed AC, 127 participants underwent...
Primary angiitis of the central nervous system (CNS) is an uncommon inflammatory disorder, with highly variable clinical presentation. It needs to be differentiated from several mimickers, such as CNS involvement in systemic vasculitides, connective tissue disorders, infectious disease, and leukodystrophy well neoplastic diseases. The diagnosis requires a combination laboratory investigations, multimodal imaging, histopathological examination, which should available for confirmation. In...
Abstract In recent years, it has become clear that artificial intelligence (AI) models can achieve high accuracy in specific pathology‐related tasks. An example is our deep‐learning model, designed to automatically detect serous tubal intraepithelial carcinoma (STIC), the precursor lesion high‐grade ovarian carcinoma, found fallopian tube. However, standalone performance of a model insufficient determine its value diagnostic setting. To evaluate impact use this on pathologists' performance,...
Objectives/Hypothesis The accurate diagnostic assessment of clinically relevant human papillomavirus (HPV) infections in patients with head and neck squamous cell carcinoma represents an urgent unmet medical need. aim this study was to determine feasibility, accuracy, clinical significance HPV16/18 E6 oncoprotein detection on cytological specimens from oropharyngeal (OPSCC) lymph node metastasis SCC unknown primary tumor (CUP) via a protein immunochromatographic assay. Study Design...
SMARCB1 inactivation is a well-established trigger event in atypical teratoid/rhabdoid tumor. Recently, role for has emerged as mechanism of clonal evolution other tumor types, including rare brain tumors. We describe an unusual malignant intra-axial SMARCB1-deficient spindle cell desmoplastic neoplasm, occurring 6-year-old child with meningioangiomatosis and long history seizures. Striking features the were storiform pattern strong CD34 expression. Undifferentiated round areas isolated...
Malignant mesothelioma is a primary neoplasm of the serosal membranes that usually presents with diffuse pattern growth. However, cases localized mesotheliomas have been described. The predominant localization pleura; peritoneum and pericardium being rarer localizations. Only few true intraparenchymal arising in organs such as liver, gonads, lung, pancreas We report case an otherwise healthy 48-year-old man without asbestos exposure nodule 3 cm diameter, spleen, discovered incidentally at...
Objective. The use of standardized structured reports (SSR) and suitable terminologies like SNOMED-CT can enhance data retrieval analysis, fostering large-scale studies collaboration. However, the still large prevalence narrative in our laboratories warrants alternative automated labeling approaches. In this project, natural language processing (NLP) methods were used to associate codes unstructured from an Italian Digital Pathology Department. Methods. Two NLP-based automatic coding systems...
<h3>Introduction/Background</h3> High-grade serous ovarian cancer (HGSOC) is the most common clinically diagnosed cancer, often considered a fatal disease. Despite increased awareness of this tumor, it generally at late stage (III or IV), implying that cells have already spread outside primary site. Although current treatments appeared to provide almost complete remission, recurrence rate still high. <h3>Methodology</h3> Here we present an innovative tissue engineering approach applied HGSOC...