A5031580048- Nuclear Physics and Applications
- Radiation Therapy and Dosimetry
- Effects of Radiation Exposure
- Nuclear reactor physics and engineering
- Radiation Detection and Scintillator Technologies
- Atomic and Subatomic Physics Research
- Advanced Radiotherapy Techniques
- Skin Protection and Aging
- Nuclear physics research studies
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Graphite, nuclear technology, radiation studies
- Carcinogens and Genotoxicity Assessment
- Chemical Reactions and Isotopes
- Diagnosis and treatment of tuberculosis
- Antibiotic Resistance in Bacteria
- Salmonella and Campylobacter epidemiology
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Radiation Effects and Dosimetry
- Nuclear Materials and Properties
- Radioactive Decay and Measurement Techniques
- HIV Research and Treatment
- Escherichia coli research studies
- Radioactive contamination and transfer
Istituto Oncologico Veneto
2023-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2024
Secretaria de Agricultura e Abastecimento
2019-2022
University of Campania "Luigi Vanvitelli"
2012-2020
University of Naples Federico II
2019
Fundação Estadual de Pesquisa Agropecuária
2012-2017
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2014
San Raffaele University of Rome
2011
Universidade Federal de Pelotas
2004-2005
National Agency for New Technologies, Energy and Sustainable Economic Development
1986-2000
Head and neck region is involved in a high percentage of malignant lesions, oral squamous cell carcinoma (OSCC) undoubtedly the most frequently found, accounting for over 90% tumors. Hormone receptor overexpression, like Estrogen Receptor (ER), Progesterone (PR) Endothelial Growth Factor (EGFR), signaling have been related to pathogenesis OSCC. For metastasis OSCC, Cancer Stem Cells (CSCs) undergo epithelial mesenchymal transition (EMT) under influence growth factors, cytokines, regulation...
Os probióticos são bactérias que produzem efeitos benéficos no hospedeiro, usadas para prevenir e tratar doenças, como promotores de crescimento imunoestimulantes. Nesta revisão abordam-se as principais aplicações dos probióticos, com ênfase nas informações recentes sobre suas propriedades modular a resposta imune.
A 3He filled proportional counter can be used for neutron detection in the range 100 keV to 8 MeV by using 3He(n,p)T reaction. The major limitation as a spectrometer is that recoil distribution, arising from elastic scattering of higher energy neutrons present, masks peaks due lower groups. Since and proton equal energies have difference specific ionizations and, therefore, different ranges filling, one thus has means distinguish between pulses 3He(n,n)3He reactions. For appropriate...
Abstract Non‐small‐cell lung carcinomas (NSCLC) is the most common type of cancer and it has a poor prognosis, because overall survival after 5 years 20–25% for all stages. Thus, extremely important to increase rate in early stages NSCLC by focusing on novel screening tests identifying specific biomarkers expression associated with more accurate tumor staging patient prognosis. In this study, we focused our attention quantitative proteomics three heavily glycosylated serum proteins: AMBP, α2...
Bovine tuberculosis (bTB) is a zoonosis caused mainly by Mycobacterium bovis that affects domestic and wild animals. In Brazil, there are no epidemiological studies on in animal populations their possible role the disease maintenance cattle herds; thus, aim of this study was to evaluate occurrence boars Rio Grande do Sul, southern Brazil. Tissue samples animals hunted under government consent were submitted histopathology M. polymerase chain reaction (PCR) as screening tests; positive...
Extension of previous investigations at this laboratory regarding life shortening and tumor induction in the mouse has provided more complete dose-response information low dose region X rays neutrons. A observation survival late pathology been carried out on over 2000 BC3F1 female mice irradiated with single doses 1.5 MeV neutrons (0.5, 1, 2, 4, 8, 16 cGy) and, for comparison, (4, 16, 32, 64, 128, 256 cGy). Data analysis shown that a significant is observable only individual neutron not...
The main object of this study is to investigate the role age on susceptibility radiation carcinogenesis and life shortening for different qualities radiation. Over last few years, a line research at Laboratory Pathology, C.R.E. Casaccia, has been set up effects exposure neutron irradiation, including observations late (both neoplastic nonneoplastic) as function dose irradiation. Graded single doses X rays or attenuated fission neutrons have given male BC3F1 mice 3 19 months old animals in...
The induction of liver tumors has been studied in BC3F1 male mice after acute whole-body irradiation with fission neutrons and X rays, given at different ages. In prenatally irradiated mice, a small effect is seen doses 0.3 to 2.1 Gy more pronounced found neutron 0.09 0.62 Gy. At 3 months age the animals show higher incidence X-ray from 2 Gy, for 0.17 19 age, are rarely induced by either type radiation. These findings confirmed statistical analysis trend. possibility deriving dose-response...
The inhibition of ErbB2 by the use human antibodies can be a valuable strategy for treatment breast and gastric cancer. Trastuzumab, humanized anti-ErbB2 antibody in clinical use, is effective but engender resistance as well cardiotoxicity. ImmunoRNases, made up scFv pancreatic ribonucleases (HP-RNases), have been engineered to overcome limits other immunotoxins, such immunogenicity nonspecific toxicity. Here, we report that novel immunoRNase, called Erb–HPDDADD-RNase, obtained fusing...
Abstract The effect of Saccharomyces boulardii and Bacillus cereus var. toyoi on the humoral cellular response mice to simultaneous inoculation a tetravalent E. coli bacterin viable vaccine against Canine Parvovirus is reported. Thirty-six isogenic BALB-c female mice, seven weeks old, were vaccinated with 1/20th dose used for pigs dogs, respectively, randomly divided into three groups. Group 1 received non-supplemented feed, group 2 was supplemented S. boulardii, 3 toyoi. quantified through...
Eye lens opacification in mice has been used to evaluate the RBE of neutrons 1, 5, and 600 MeV.The experimental observations were based on counting points opacities appearing posterior region lens.RBE values have calculated with reference equal effects observed after exposure 250 kVp X-rays.Data previously reported for 15 400 MeV also included.It is found that all neutron energies increases decreasing dose.In addition, at very low doses appears reach about same value independently energy...
Testes weight loss in mice has been used as a test system to determine the relative biological efficiency (RBE) of neutrons ranging energy from fission beam 600 MeV nominal energy. The RBE values, calculated equal effect dose ratios show maximum at neutron 1 MeV. No significant dependence was found on level absorbed dose. Analyses dose-effect relations obtained suggest existence radiation-insensitive component testes that accounts for 32.5% total weight. By considering only radiosensitive...
The dependence of gamma-ray attenuation on the chemical composition soils is investigated in energy range from 10 keV to 3 MeV. Mass coefficients have been calculated for five soil types, showing appreciable variations with region energies up a maximum 300 keV. influence determination dry bulk density and moisture content by method considered.
We have investigated the effect of fission-spectrum neutron dose fractionation on neoplastic transformation exponentially growing C3H 10T1/2 cells. Total doses 10.8, 27, 54, and 108 cGy were given in single or five equal fractions delivered at 24-h intervals biological channel RSV-TAPIRO reactor CRE-Casaccia. Both cell inactivation more effectively induced by fission neutrons than 250-kVp X rays. No significant survival was observed with split compared to neutrons. Neutron RBE values...
The present analysis of data on the induction lymphoma and myeloid leukemia in BC3F1 mice has indicated some new interesting aspects regarding shapes dose-effect curves. incidence can be interpreted by radiobiological models process coupled with cell inactivation. In particular, for malignant dose-response curve after X rays described assuming a quadratic model corrected inactivation, while fission neutrons are best fitted linear which also allows Myeloid been induced mice. bell-shaped...