A5018469329- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- Herpesvirus Infections and Treatments
- T-cell and Retrovirus Studies
- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- Vector-Borne Animal Diseases
- Natural product bioactivities and synthesis
- Microbial infections and disease research
- Cervical Cancer and HPV Research
- Viral Infections and Vectors
- Aquaculture disease management and microbiota
- Salmonella and Campylobacter epidemiology
- Toxin Mechanisms and Immunotoxins
- Essential Oils and Antimicrobial Activity
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Virology and Viral Diseases
- Respiratory viral infections research
- Toxoplasma gondii Research Studies
- Mosquito-borne diseases and control
- Parvovirus B19 Infection Studies
Universidade Estadual da Paraíba
2024-2025
Universidade Federal do Rio Grande do Norte
2025
Universidade Federal da Paraíba
2018-2024
Universidade Federal do Rio Grande do Sul
2013-2023
Secretaria de Agricultura e Abastecimento
2020-2023
Universidade Federal do Rio Grande
2019
Fundação Estadual de Pesquisa Agropecuária
2009-2018
Ludwig-Maximilians-Universität München
2016
München Klinik
2016
Animal Health Institute
2015
Two full-genome sequences of porcine circovirus type 3 (PCV3) are reported. The genomes were recovered from pooled serum samples sows who had just delivered litters with variable numbers stillbirths. two circular (PCV3-BR/RS/6 and PCV3-BR/RS/8) 2,000 nucleotides long contain open reading frames (ORFs) oriented in opposite directions that encode the putative capsid (Cap) replicase (Rep) proteins. intergenic region contains a stem-loop motif, as reported for other circoviruses. Rolling circle...
This study is focused on the identification of faecal virome healthy chickens raised in high-density, export-driven poultry farms Brazil. Following high-throughput sequencing, a total 7743 de novo-assembled contigs were constructed and compared with known nucleotide/amino acid sequences from GenBank database. Analyses blastx revealed that 279 (4 %) related to eukaryotic viruses. Viral genome (total or partial) indicative members recognized viral families, including Adenoviridae,...
The adjuvant activity of Chenopodium quinoa (quinoa) saponins on the humoral and cellular immune responses mice subcutaneously immunized with ovalbumin (OVA) was evaluated. Two saponin fractions were obtained, FQ70 FQ90, 10 determined by UPLC/Q-TOF-MS. Mice OVA alone or adjuvanted Quil A (adjuvant control), FQ70, FQ90. FQ90 significantly enhanced amount anti-OVA-specific antibodies in serum (IgG, IgG1, IgG2b) mice. effect greater than that However, delayed type hypersensitivity higher...
Recently, a putative new pestivirus species, provisionally named as Atypical Porcine Pestivirus (APPV), was associated with the congenital tremor in piglets North America and consequently Europe Asia. The present research aimed to describe detection characterization of APPV employing NS5B gene partial sequencing, gross pathology histologic examination displaying from two different farms Southern Brazil. No lesions were observed, histological findings revealed moderate vacuolization white...
Commercially available saponins are extracted from Quillaja saponaria barks, being Quil A
Circoviruses are highly prevalent porcine and avian pathogens. In recent years, novel circular ssDNA genomes have recently been detected in a variety of fecal environmental samples using deep sequencing approaches. this study the identification circoviruses cycloviruses feces insectivorous bats is reported. Pan-reactive primers were used targeting conserved rep region to screen DNA bat samples. Using approach, partial sequences which formed five phylogenetic groups distributed among...
Quillaja brasiliensis (Quillajaceae) is a saponin producing species native from southern Brazil and Uruguay. Its saponins are remarkably similar to those of Q. saponaria, which provides most the used as immunoadjuvants in vaccines. The immunostimulating capacities aqueous extract (AE) purified fraction (QB-90) obtained leaves were favorably comparable commercial saponin-based adjuvant preparation (Quil-A) experimental vaccines against bovine herpesvirus type 1 5, poliovirus viral diarrhea...
Although the use of vaccines has controlled enteric diseases in dogs many developed countries, vaccine coverage is still under optimal situation Brazil. There a large population nonimmunized and few studies about identification viruses associated with diarrhea. To address this situation, stool samples from 325 were analyzed by polymerase chain reaction for detection common such as Canine adenovirus (CAdV), coronavirus (CCoV), distemper virus (CDV), rotavirus (CRV) Carnivorous protoparvovirus...
The Euphorbiaceae family is renowned for its diverse array of compounds, primarily diterpenes, which exhibit multiple biological activities. In Brazil, the genera Jatropha, Cnidoscolus, Sapium, and Stillingia are predominantly found in Northeast region. Despite their significant pharmacological potential, chemical profiles these species remain underexplored. this context, chemotaxonomic a tool to identify potential markers bioactive structures within given taxon. order analyze patterns among...
Inactivated polio vaccines (IPV) have an important role at the final stages of poliomyelitis eradication programs, reducing risks associated with use attenuated vaccine (OPV). An affordable option to enhance immunogenicity and reduce costs IPV may be effective renewable adjuvant. In present study, adjuvant activity aqueous extract (AE) saponin fraction QB-90 from Quillaja brasiliensis using poliovirus antigen as model were analyzed compared a preparation adjuvanted Quil-A, well-known...
Abstract A co-infection comprising to at least seven papillomavirus (PV) types was detected by next generation sequencing (NGS) of randomly primed rolling circle amplification (RCA) products a bovine ( Bos taurus ) papilloma lesion from the Brazilian Amazon region. Six putative new PV that could not be commonly used PCR protocols were identified. Their overall L1 nucleotide identities less than 90% compared described species and types. BLAST sequence hits showed each type related Beta, Gamma...
Using metagenomic approaches, we identified a novel Torque teno virus from Brazilian free-tailed bats (Tadarida brasiliensis) (TT-TbV). The TT-TbV genome and deduced protein sequences share extremely low identity with known anelloviruses. Due to high degree of phylogenetic divergence, such putative could not be allocated into any Anelloviridae genera.
Saponin-based adjuvants are promising that enhance both humoral and T-cell-mediated immunity. One of the most used natural products as vaccine Quillaja saponaria bark saponins its fraction named Quil A®. Despite that, use has been restricted for human due to safety issues. As an alternative, our group studying congener species brasiliensis performance adjuvants, which have shown trigger cellular immune responses comparable A® but with milder side effects. Here, we studied a semi purified...