A5004459794- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Cervical Cancer and HPV Research
- Immunotherapy and Immune Responses
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Gynecological conditions and treatments
- Endometriosis Research and Treatment
- BRCA gene mutations in cancer
- Intraperitoneal and Appendiceal Malignancies
- PARP inhibition in cancer therapy
- Nanoplatforms for cancer theranostics
- Radiomics and Machine Learning in Medical Imaging
- Advanced Chemical Physics Studies
- Delphi Technique in Research
- Astrophysics and Star Formation Studies
- Genetic factors in colorectal cancer
- AI in cancer detection
- Neuroendocrine Tumor Research Advances
- Photodynamic Therapy Research Studies
- Gestational Trophoblastic Disease Studies
- DNA Repair Mechanisms
- Mechanisms of cancer metastasis
Radboud University Nijmegen
2015-2025
Radboud University Medical Center
2015-2025
Radboud Institute for Molecular Life Sciences
2017-2022
Alfred University
2021
University Medical Center
2015-2019
Canisius-Wilhelmina Ziekenhuis
2017
<h3>Background</h3> Clinical benefit of cellular immunotherapy has been shown in patients with castration-resistant prostate cancer (CRPC)<b>.</b> We investigated the immunological response and clinical outcome vaccination blood-derived CD1c<sup>+</sup> myeloid dendritic cells (mDCs; cDC2) plasmacytoid DCs (pDCs). <h3>Methods</h3> In this randomized phase IIa trial<b>,</b> 21 chemo-naive CRPC received maximally 9 vaccinations mature mDCs, pDCs or a combination mDCs plus pDCs. were stimulated...
Abstract Background Women with epithelial ovarian cancer (OC) have a higher chance to benefit from poly (ADP-ribose) polymerase inhibitor (PARPi) therapy if their tumor has somatic or hereditary BRCA1/2 pathogenic variant. Current guidelines advise genetic predisposition testing for all OC patients, though this does not detect variants. We assessed the feasibility of workflow universal DNA newly diagnosed patients as prescreen PARPi treatment and testing. Methods Formalin-fixed...
<h3>Background</h3> Risk-reducing salpingectomy with delayed oophorectomy has gained interest for individuals at high risk tubo-ovarian cancer as there is compelling evidence that especially high-grade serous carcinoma originates in the fallopian tubes. Two studies have demonstrated a positive effect of on menopause-related quality life and sexual health compared standard risk-reducing salpingo-oophorectomy. <h3>Primary Objective</h3> To investigate whether non-inferior to current...
With the recent introduction of Poly(ADP-ribose) polymerase inhibitors, a promising novel therapy has become available for ovarian carcinoma (OC) patients with inactivating BRCA1 or BRCA2 mutations in their tumor. To select who may benefit from these treatments, assessment mutation status and tumor is required. For reliable evaluation germline somatic genes DNA derived formalin-fixed, paraffin-embedded (FFPE) tissue, we have developed single-molecule molecular inversion probe (smMIP)-based...
Context. Glycoaldehyde, ethylene glycol, and methyl formate are complex organic molecules that have been observed in dark molecular clouds. Because there is no efficient gas-phase route to produce these species, it expected a low-temperature surface existst does not require energetic processing. CO hydrogenation experiments at low temperatures showed this indeed the case. Glyoxal can form through recombination of two HCO radicals then further hydrogenated. Aims. Here we aim constrain...
Increased hereditary cancer risk is one of the hallmarks PTEN Hamartoma Tumor Syndrome (PHTS) which caused by a pathogenic germline variant in PTEN. Case reports and some cohort studies have described ovarian (OC) PHTS patients. Previously, we observed an enrichment non-serous OC compared to sporadic cases (3% vs 1%). However, currently not considered PHTS-related cancer. The aim this study was describe five patients with OC. Three OCs were mucinous carcinomas (49, 51 52 years) two malignant...
A significant proportion of ovarian malignancies consists metastatic tumors, with a wide variety in site origin. Differentiating between primary and malignancy the ovaries can be difficult misdiagnosis might have considerable impact on both treatment prognosis. To further examine origin to ovary, we performed large-scale, nationwide search for metastases Dutch Pathology Registry (PALGA). All pathology reports concerning ovary associated tumors Netherlands 2000 2010 were collected. Age, year...
Incomplete resection of prostate cancer (PCa) occurs in 15%-50% PCa patients. Disease recurrence negatively impacts oncological outcome. The use radio-, fluorescent-, or photosensitizer-labeled ligands to target the prostate-specific membrane antigen (PSMA) has become a well-established method for detection and treatment PCa. Methods: Here, we developed characterized multimodal [111In]In-DOTA(GA)-IRDye700DX-PSMA ligands, varying their molecular composition, intraoperative radiodetection,...
Patients with mucinous ovarian carcinoma (MOC) generally have a favorable prognosis, although in advanced stage, prognosis is significantly worse compared to patients serous carcinomas (SOCs). This might be due the difficulties distinguishing MOC from metastatic tumors. In current study, we investigate of other types cancer and synchronous metastases ovary (sMO). Age, laterality, International Federation Gynecology Obstetrics tumor grade, treatment, survival were extracted Eindhoven Cancer...
Reliably diagnosing or safely excluding serous tubal intraepithelial carcinoma (STIC), a precursor lesion of tubo-ovarian high-grade (HGSC), is crucial for individual patient care, better understanding the oncogenesis HGSC, and investigating novel strategies to prevent carcinoma. To optimize STIC diagnosis increase its reproducibility, we set up three-round Delphi study.In round 1, an international expert panel 34 gynecologic pathologists, from 11 countries, was assembled provide input...
Incomplete resection of prostate cancer (PCa) results in increased risk disease recurrence. Combined fluorescence-guided surgery with tumor-targeted photodynamic therapy (tPDT) may help to achieve complete tumor eradication. We developed a prostate-specific membrane antigen (PSMA) ligand consisting DOTA chelator for 111In labeling and fluorophore/photosensitizer IRDye700DX (PSMA-N064). evaluated the efficacy PSMA-tPDT using PSMA-N064 cell viability assays, mouse xenograft model an ex vivo...
Abstract Tubo-ovarian high-grade serous carcinoma is believed to originate in the fallopian tubes, arising from precursor lesions like tubal intraepithelial (STIC) and lesion (STIL). Adequate diagnosis of these precursors important, but can be challenging for pathologists. Here we present a deep-learning algorithm that could assist pathologists detecting STIC/STIL. A dataset STIC/STIL ( n = 323) controls 359) was collected split into three groups; training 169), internal test set 327),...
Primary mucinous ovarian carcinomas (MOC) are notoriously difficult to distinguish from metastatic the ovary (mMC). Studies performed on small cohorts reported algorithms based tumor size and laterality aid in distinguishing MOC mMC. We evaluated improved these by performing a large-scale, nationwide search Dutch Pathology Registry. All registered pathology reports fulfilling our criteria concerning Netherlands 2000 2011 were collected. Age, histology, laterality, extracted. An existing...
Abstract Umbilical metastases form a clinical challenge, especially when they represent the first sign of malignant disease and primary tumor is unknown. Our study aims to generate insight into origin timing umbilical metastasis, as well patient survival, using population‐based data. A nationwide review pathology records patients diagnosed with an metastasis between 1979 2015 was performed. Data collected from Nationwide Network Registry Histopathology Cytopathology (PALGA) Netherlands...
A Serous Tubal Intraepithelial Carcinoma (STIC) without concomitant invasive carcinoma is occasionally identified and associated with a high risk of subsequent peritoneal carcinomatosis. Management needs optimisation. This study explores professionals' opinions clinical practices regarding the diagnosis, counselling, treatment follow-up isolated STIC to facilitate decision making optimise direction future research. secondary aim assess international guidelines.
Checkpoint inhibitors targeting PD-(L)1 induce objective responses in 20% of patients with metastatic urothelial cancer (UC). CD8 + T cell infiltration has been proposed as a putative biomarker for response to checkpoint inhibitors. Nevertheless, data on spatial and temporal heterogeneity tumor-infiltrating lymphocytes advanced UC are lacking. The major aims this study were explore lymphocyte investigate how the immune landscape changes during disease course. We performed multiplex...
Homologous recombination repair deficiency (HRD) is observed in 10% of patients with castrate-resistant prostate cancer (PCa). Preliminary data suggest that HRD-PCa might be more responsive to immune checkpoint inhibitors (ICIs). In this study, we compare the tumor landscape and peripheral T cell receptor (TCR) repertoire without gain further insight into immunogenicity HRD-PCa. Immunohistochemistry was performed on tissue 81 patients, including 15 Peripheral TCR sequencing a partially...
<h3>Introduction/Background</h3> High-grade serous ovarian cancer originates mainly from precursor lesions in the fallopian tube, called 'Serous Tubal Intraepithelial Carcinoma' (STIC). A STIC is indicated as 'isolated' when occurring without a concurrent carcinoma. In 3% of BRCA mutation carriers, an isolated found during preventive removal tubes and ovaries. Recently, lesion carriers was associated with high risk peritoneal carcinomatosis. Currently, there no clear management for patients...
Individuals with germline pathogenic variants in BRCA1 or BRCA2 are at a high risk of breast and ovarian carcinomas BRCA1/2 deficiency homologous recombination that can be detected by analysis genome-wide genomic instability features such as large-scale state transitions, telomeric allelic imbalances, loss heterozygosity. Malignancies more sensitive to platinum-based therapies poly(ADP-ribose) polymerase inhibitors. We investigated the fraction non-breast malignancies have features.