A5070488540- Inflammatory mediators and NSAID effects
- Metabolism, Diabetes, and Cancer
- Colorectal Cancer Treatments and Studies
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Pharmacogenetics and Drug Metabolism
- Diabetes Treatment and Management
- Cancer Treatment and Pharmacology
- Chemotherapy-induced cardiotoxicity and mitigation
- Pancreatic and Hepatic Oncology Research
- Estrogen and related hormone effects
- Genetic factors in colorectal cancer
- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Gastroesophageal reflux and treatments
- Cancer, Stress, Anesthesia, and Immune Response
- HER2/EGFR in Cancer Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Medication Adherence and Compliance
- Ovarian cancer diagnosis and treatment
- Lung Cancer Research Studies
- Economic and Financial Impacts of Cancer
- Neuroendocrine Tumor Research Advances
- Diet and metabolism studies
- Neutropenia and Cancer Infections
University Medical Center Utrecht
2018-2023
Netherlands Comprehensive Cancer Organisation
2022
Pharmo Institute
2010-2019
Utrecht University
2010
Leiden University Medical Center
2010
Emma Kinderziekenhuis
2004
Amsterdam UMC Location University of Amsterdam
2004
Numerous studies have suggested a decreased risk of cancer in patients with diabetes on metformin. Because different comparison groups were used, the effect magnitude is difficult to estimate. Therefore, objective this study was further analyze whether, and what extent, use metformin associated cohort incident users compared sulfonylurea derivatives.Data for obtained from dispensing records community pharmacies individually linked hospital discharge 2.5 million individuals Netherlands. The...
The use of cytochrome P450 2D6-inhibiting drugs (CYP2D6 inhibitors) during tamoxifen treatment leads to a decrease in plasma concentration endoxifen, the major active metabolite. Concomitant CYP2D6 inhibitors, such as selective serotonin reuptake well low adherence may negatively impact efficacy patients with breast cancer. objectives this study were relate concomitant inhibitor and cancer event-free time (EFT).Data from PHARMO included community pharmacy dispensing database; PALGA,...
The preventive role of non-steroid anti-inflammatory drugs (NSAIDs) and aspirin, in particular, on colorectal cancer is well established. More recently, it has been suggested that aspirin may also have a therapeutic role. Aim the present observational population-based study was to assess effect overall survival aspirin/NSAIDs as adjuvant treatment used after diagnosis patients.Data concerning prescriptions were obtained from PHARMO record linkage systems all patients diagnosed with...
Use of aspirin (which inhibits platelet function) after a colon cancer diagnosis is associated with improved overall survival. Identifying predictive biomarkers this effect could individualize therapy and decrease toxic effects.
Several publications suggest an association between certain types of insulin and cancer, but with conflicting results. We investigated whether glargine (A21Gly,B31Arg,B32Arg human insulin) is associated increased risk cancer in a large population-based cohort study. Data for this study were obtained from dispensing records community pharmacies individually linked to hospital discharge 2.5 million individuals the Netherlands. In incident users insulin, other analogues, respectively, was...
Abstract Type 2 diabetes mellitus (T2DM) is associated with greater risk for colorectal cancer (CRC). The age of onset T2DM decreasing worldwide. An increased CRC in young patients could be relevant the at which to initiate screening. We report on attention diagnosis. used pharmacy data (from 1998 2010) from PHARMO Database Network linked Eindhoven Cancer Registry. Multivariable time-dependent Cox regression analyses were conducted calculate hazard ratios (HR) developing comparing non-T2DM....
Metformin, statin and aspirin use seem associated with decreased mortality in cancer patients, though, without adjusting for one another. Independent associations of these drugs overall after colorectal (CRC) diagnosis within glucose-lowering (GLDs) users were assessed. Patients starting GLDs before CRC (1998–2011) selected from the Eindhoven Cancer Registry linked PHARMO Database Network. The Cox regression model, time since diagnosis, included time-dependent variables cumulative exposure...
Abstract We examined the incidence of cardiovascular disease ( CVD ) among 32 757 cancer survivors and age‐, gender‐, geographically matched cancer‐free controls during a follow‐up period 1‐13 years, explored whether differed by received treatment, traditional risk factors, age, or gender. Adult 1‐year without history diagnosed with breast (n = 6762), prostate 4504), non‐Hodgkin 1553), Hodgkin 173), lung trachea 2661), basal cell carcinoma BCC ; n 12 476), colorectal 4628) 1999‐2011 were...
Objectives To assess survival in relation to aspirin use after diagnosis older adults with colon cancer. Design Subgroup analysis of a previously published cohort and retrospective study. Setting Individuals registered the Eindhoven Cancer Registry ( ECR ) between 1998 2007, linked prescriptions low‐dose (80 mg) community pharmacy database. Participants Five hundred thirty‐six individuals aged 70 diagnosed cancer or without diagnosis. Measurements Survival was analyzed user status as...
Previous studies suggested a relationship between aspirin use and mortality reduction. The mechanism for the effect of on cancer outcomes remains unclear. aim this study was to evaluate survival in patients with gastrointestinal tract cancer. Patients diagnosed 1998 2011 were included. population-based Eindhoven Cancer Registry linked drug-dispensing data from PHARMO Database Network. association after diagnosis overall analysed using Cox regression models. In total, 13 715 A total 1008...
To determine the association between opioid use and occurrence of postoperative paralytic ileus (POI) after different types surgery.The PHARMO database was used to perform a case control study in which intramural drug utilisation data were linked hospital discharge diagnoses. All patients admitted for digestive, abdominal or genito-urinary surgeries selected 1998-2003. Cases with coded POI (ICD-9-CM 560.1 564.4) controls no matched 1:10. The assessed using conditional logistic regression.In...