A5090072822- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Catalytic Reactions
- Chemical Thermodynamics and Molecular Structure
- Crystal structures of chemical compounds
- Polymer Synthesis and Characterization
- Metal-Organic Frameworks: Synthesis and Applications
- Asymmetric Synthesis and Catalysis
- Synthesis of heterocyclic compounds
- Enzyme function and inhibition
- Organic and Molecular Conductors Research
- Metal complexes synthesis and properties
- Synthesis and pharmacology of benzodiazepine derivatives
- Cholinesterase and Neurodegenerative Diseases
- Pediatric health and respiratory diseases
- Synthesis and Reactions of Organic Compounds
St Petersburg University
2022-2024
Yaroslavl State Pedagogical University
2018-2022
Herein, we developed a new synthetic approach for the preparation of N-arylated 1,2,4-oxadiazin-5(6H)-ones by direct arylation with diaryliodonium salts. The reaction symmetrical salts using CuI as catalyst proceeded in toluene presence DIPEA at 60 °C formation desired products isolated yields 46 to 97% (20 examples). use more readily available unsymmetrical required higher temperatures (up 100 °C) achieve similar yields. only limitation observed was an ortho-substituted iodonium salt. In...
The cis- and trans-isomers of 6-(3-(3,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl)cyclohex-3-ene-1-carboxylic acid (cis-A trans-A) were obtained by the reaction 3,4-dichloro-N′-hydroxybenzimidamide cis-1,2,3,6-tetrahydrophthalic anhydride. Cocrystals cis-A with appropriate solvents (cis-A‧½(1,2-DCE), cis-A‧½(1,2-DBE), cis-A‧½C6H14) grown from 1,2-dichloroethane (1,2-DCE), 1,2-dibromoethane (1,2-DBE), a n-hexane/CHCl3 mixture then characterized X-ray crystallography. In their structures, is...
Relying on a recently suggested protocol that furnishes convenient access to variously substituted 2-pyridyl ureas, twelve hitherto unknown Cu(II) complexes have been synthesized in the present work and their structures were evaluated by elemental analysis, HRMS, IR spectroscopy, X-ray diffraction study. Two structural motifs ([Cu(L)2Cl]+[Cl]- or (Cu(L)2Cl2) depending substitution pattern 2-pyridine fragment revealed. In addition, antiproliferative action of obtained compounds investigated...
A series of 2,5-dibromo-3-R-thiophenes (R = COONa 1, CN 2, CONH2 3, CON(H)Me 4, CON(H)Bn 5, CON(CH2CH2)2O 6, CON(H)NH2 7, CON(H)OH 8) were prepared and studied via high-resolution ESI-MS, 1H 13C{H} NMR, IR, X-ray diffraction. The analysis the structures revealed Br···Br halogen bonds (XBs) as structure-directing interactions. search Cambridge Structural Database showed an additional 12 2,5-dibromothiophenes whose featured XBs. crystal packing patterns for all these classified, three general...
Efficient approaches towards the synthesis of various N-substituted 1,3,5-triazinanes based on a transformation N-alkyl-1,5,3-dioxazepanes or domino reaction involving condensation amines, amides, and paraformaldehyde are described for first time. Mg(ClO4)2 was shown to be one most potent additives condensation. The proposed permit broad spectrum substituted sym-triazinanes in good yields with relatively easy workup. In case multicomponent reaction, approach allows preparation target...
We have developed a simple and convenient method for the synthesis of 3-aryl- 3-hetaryl-1,2,4-oxadiazin-5-ones bearing an easily functionalizable (methoxycarbonyl)methyl group at position 6 via reaction aryl or hetaryl amidoximes with maleates fumarates. The conditions this were optimized. Different products can be synthesized selectively in good yields depending on base used ratio reactants: substituted (1,2,4-oxadiazin-6-yl)acetic acids, corresponding methyl esters, hybrid...
Monoamine oxidase (MAO) plays a key role in the pathogenesis of central nervous system disorders, and MAO inhibitors have been used treatment depression Parkinson's disease. In search for new classes inhibitors, present study investigated series 1,2,4-oxadiazin-5(6