A5027862727- Synthesis and Reactions of Organic Compounds
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Chemical Reaction Mechanisms
- Boron Compounds in Chemistry
- Synthesis of heterocyclic compounds
- Fluorine in Organic Chemistry
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Radiopharmaceutical Chemistry and Applications
- Chemical Synthesis and Reactions
- Chemical Synthesis and Analysis
- Fullerene Chemistry and Applications
- Synthesis of Organic Compounds
- Organic Chemistry Cycloaddition Reactions
- Oxidative Organic Chemistry Reactions
- Inorganic and Organometallic Chemistry
- Catalytic Cross-Coupling Reactions
- Chemical Reactions and Isotopes
- Vanadium and Halogenation Chemistry
- Chemical Reactions and Mechanisms
- Organic and Inorganic Chemical Reactions
National Academy of Sciences of Belarus
2016-2025
Institute of Physical and Organic Chemistry
2014-2025
University of Glasgow
2023
Association of Research Libraries
2023
University of Hong Kong
2023
Florida Institute of Technology
2023
Environment and Health Group (United States)
2023
Jiaxing University
2020
Institute of Physiology National Academy of Sciences of Belarus
2015
Lomonosov Moscow State University
2014
The chemistry of isothiazoles is being intensively developed, which evidenced by the wide range selective transformations involving isothiazole heterocycle and high biological activity its derivatives that can be used as effective new drugs plant protection chemicals. Some representatives have proven to synergists bioactive substances, opens way lower doses especially important in cancer chemotherapy. In framework present review, accomplishments over past 18 years are examined, whilst...
Replenishing the range of natural and synthetic medicinal substances with different anti-inflammatory activity is an urgent task modern pharmaceuticals. Studying chemical compounds through bioscreening in vitro vivo studies a lengthy labor-intensive procedure. This paper presents data on antyinflammatory nitrogenous heterocyclic model acute exudative reaction (peritonitis) comparison obtained results ab initio quantum calculations using density functional theory method. Among 16 studied...
In 2022, the number of mpox cases spiked worldwide, leading to a surge in scientific research on members Orthopoxvirus genus and discovery new compounds exhibiting anti-orthopoxvirus activity. This work is devoted synthesis containing an adamantane fragment evaluation their activity against vaccinia virus, offering possible mechanism antiviral action synthesized agents. Among all studied derivatives, three (2, 4, 12) were found demonstrate highest activity, with most promising compound 2...
An unexpected four-step sequence of reactions was discovered in the course investigation interactionbetween3-(isoxazol-3-yl)allylamines and maleic or trifluoromethylmaleic anhydrides. This conversion begins with initial N-acylation the...
A air and moisture stable square-planar trans-dichloropalladium(II) complex containing two 5-(p-tolyl)isoxazol-3-amine ligands was synthesized structurally characterized by single-crystal X-ray diffraction. The isoxazol-3-amine ligand prepared from 5-(p-tolyl)isoxazole-3-carbaldehyde oxime successive transformations. new is a high-turnover-number catalyst for the Suzuki-Miyaura reaction with low palladium loading (0.0001-0.1%) in neat water under an atmosphere.
Neuroepithelial tumor cells were cultured in vitro. The biopsy material was taken from 93 children at removal of the brain tumors during neurosurgical operations. individual features sensitivity primary cultures respect to protocol-approved chemotherapy drugs and changes Interleukin-6 (Il-6) level culture medium after application established. initial Il-6 exceeded 600.0 pg/ml cultural with histologically verified pilomyxoid astrocytoma cells, ranged 100.0 200.0 cultivation...
Abstract To increase the in vivo stability of cationic gene carriers and avoid adverse effects their positive charge, we synthesized a new shielding material by conjugating low molecular weight polyethylene glycol (PEG) to hyaluronic acid (HA) core. The HA-PEG conjugate assembled with positively charged complex, forming protective layer through electrostatic interactions. DNA/polyetherimide/HA-PEG (DNA/PEI/HA-PEG) nanoparticles had higher than both DNA/polyethyleneimine (DNA/PEI) DNA/PEI/HA...
The most recent achievements in the chemistry of isothiazoles are generalised and systematised. main applications isothiazole derivatives surveyed. bibliography includes 293 references.
We report for the first time cyclic phosphine-free "head to tail" N,N,N pincer-like (pincer complexes mimicking) N-(pyrimidin-2-yl)-1,2-azole-3-carboxamide Pd(II) with deprotonated amide groups as high-turnover catalysts (TON up 106, TOF 1.2 × 107 h-1) cross-coupling reactions on background of quantitative yields under Green Chemistry conditions. The potency described catalyst family representatives was demonstrated in Suzuki-Miyaura, Mizoroki-Heck, and Sonogashira industrially practical...
The main methods of the synthesis nitrobutadienes and their halogen derivatives, which are multipurpose electrophiles, surveyed. literature data on chemical transformations generalised, possibilities for preparation new polyfunctional derivatives different classes basis nitro- halo-nitrobutadienes that have been inaccessible earlier demonstrated. bibliography includes 112 references.
In the era of increasing effectiveness treatment methods and drugs used in modern neuro-oncology, targeted delivery diagnostic medicinal substances to tumor is great importance. The aim work study silico optimal rational approaches creation nanocontainers for drug delivery. Here we present results DFT simulation molecular electronic structure, as well possible mechanisms formation water-soluble conjugate cytotoxic cisplatin (cis-[Pt(NH3)2Cl2]) fullerenol (C60(OH)24). calculations were...
By alkylation of vanillin with 4,5-dichloro-3-chloromethylisothiazole the corresponding ether was synthesized. The latter then reacted p-toluidine to afford azomethine. During bioassays synthesized isothiazolic derivatives in mixtures insecticides (imidacloprid and a-cypermethrin) a strong synergetic effect observed.
In this work, 1,4-dioxane-mediated hydroxylhydrative aza-cyclization of 2-alkynylbenzamide is developed for the synthesis 3-hydroxylisoindolin-1-ones. The transformation proceeds smoothly in water with good yields and a broad reaction scope. Mechanistic studies show that regioselective brimonative 5-exo-dig aza-cyclization, bromohydration resulting alkene groups, hydrolysis dibromo compounds are involved. Compared to traditional methodologies, synthetic procedure reported herein represents...
The review is dedicated to the analysis of modern nanotechnologies, presented in patents and research articles aimed at optimization cancer diagnostics treatment. attention focused on dendrimers, fullerenes heterocyclic compounds with antitumor effect. mechanisms activity nanoparticles manifest intracellular, cellular, tissue, organ system levels. Such diverse effect from DNA mitochondria level immune neurohumoral defense reactions perplexes development targeted agents. authors propose pay...