A5069770533- Hearing Loss and Rehabilitation
- Obstructive Sleep Apnea Research
- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Impairment and Communication
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Extracellular vesicles in disease
- Single-cell and spatial transcriptomics
- Neuroinflammation and Neurodegeneration Mechanisms
- Noise Effects and Management
- Family and Disability Support Research
- Spinal Dysraphism and Malformations
- Neuroscience of respiration and sleep
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Inclusion and Disability in Education and Sport
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
Washington University in St. Louis
2021-2025
Zero to Three
2023
National Institutes of Health
2022
Center for Cancer Research
2022
National Cancer Institute
2022
Brigham and Women's Hospital
2021
Massachusetts Institute of Technology
2020
Abstract There is evidence that tumor immunobiology and immunotherapy response may differ between African American European prostate cancer patients. Here, we determine if men of descent harbor a unique systemic immune-oncological signature measure 82 circulating proteins in almost 3000 Ghanaian, American, men. Protein signatures for suppression immunity chemotaxis are elevated West ancestry. Importantly, the protein associates with metastatic lethal cancer, pointing to clinical importance....
To investigate parent-child agreement on fatigue reporting in pediatric otolaryngology patients and whether might vary by diagnosis other patient factors. Cross-sectional survey. Patients ages 5-18 years old being evaluated for hearing loss (HL) or obstructive sleep apnea (OSA) were recruited from a clinic center. Children parents completed the Pediatric Quality of Life Inventory Multidimensional Fatigue Scale (PedsQL MFS). Responses 42 with HL, 49 OSA, 10 sleep-disordered breathing (SDB),...
Autoimmune diabetes is a rare but severe endocrine toxicity induced by immune checkpoint inhibitor (ICI) treatment. It unclear if ICI causes selective islet or non-selective pancreas toxicity. We analyzed 11 patients treated with who developed ICI-related autoimmune diabetes. Eight had lipase and/or amylase tested on the same day of diagnosis Among them, 75% (6/8) normal and 100% (6/6) amylase. There was no correlation between glucose level at onset biochemical pancreatitis. characterized...
Objective To investigate the fatigue levels of children with hearing loss (HL) and obstructive sleep apnea (OSA), hypothesizing that experienced by HL is under‐recognized. Study Design Cross‐sectional survey. Methods We identified aged 2–18 HL, OSA, sleep‐disordered breathing (SDB), controls from a pediatric otolaryngology clinic center. Children and/or parents completed Pediatric Quality Life Inventory Multidimensional Fatigue Scale (PedsQL MFS), Hearing Environments And Reflection on...
To investigate the relationship between pediatric obstructive sleep apnea (OSA) severity and quality of life (QOL).
Objective: The parent-proxy Preschool HEAR-QL (Hearing Environments And Reflections on Quality of Life) is a quality life (QOL) measure for 2 to 6-year-old children with hearing loss (HL). We compared scores HL and normal (NH) examine the measure's discriminant validity. Study Design: Cross-sectional study. Setting: Three tertiary care pediatric otolaryngology clinics. Patients: Two hundred forty-eight parents 6 years old NH or participated. Interventions: None. Main Outcome Measure: has...
Objective: We explored whether children with hearing loss (HL) and their parents perceive the child's quality of life (QOL) similarly using Hearing Environment And Reflections on Quality Life (HEAR-QL) survey. Study Design: Cross-sectional study. Setting: Pediatric otolaryngology clinic. Patients: 7 to 14 year old unilateral or bilateral HL parents. Interventions: None. Main Outcome Measure: The HEAR-QL is a validated hearing-related QOL survey has three domains total score, ranging from 0...