A5057545891- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Global Cancer Incidence and Screening
- Chromatin Remodeling and Cancer
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Cancer Risks and Factors
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- FOXO transcription factor regulation
- vaccines and immunoinformatics approaches
- Fatty Acid Research and Health
- Genetic factors in colorectal cancer
- Lipid metabolism and biosynthesis
- Chronic Lymphocytic Leukemia Research
- Genetic Associations and Epidemiology
- Genomic variations and chromosomal abnormalities
- RNA Research and Splicing
- RNA modifications and cancer
- MicroRNA in disease regulation
- Gene expression and cancer classification
- Immunotherapy and Immune Responses
National Institutes of Health
2020-2023
Center for Cancer Research
2021-2023
University of Massachusetts Boston
2022-2023
National Cancer Institute
2020-2023
Case Western Reserve University
2023
University College Hospital, Ibadan
2022
Government of the United States of America
2022
Abstract There is evidence that tumor immunobiology and immunotherapy response may differ between African American European prostate cancer patients. Here, we determine if men of descent harbor a unique systemic immune-oncological signature measure 82 circulating proteins in almost 3000 Ghanaian, American, men. Protein signatures for suppression immunity chemotaxis are elevated West ancestry. Importantly, the protein associates with metastatic lethal cancer, pointing to clinical importance....
Importance The biological processes that underlie the association of neighborhood environment with chronic diseases, such as cancer, remain poorly understood. Objective To determine whether differences in breast tissue DNA methylation are associated deprivation among Black and White women cancer. Design, Setting, Participants This cross-sectional study collected from undergoing surgery for cancer between January 1, 1993, December 31, 2003. were recruited through University Maryland Medical...
Abstract Women of African descent have the highest breast cancer mortality in United States and are more likely than women from other population groups to develop an aggressive disease. It remains uncertain what extent Africa is reminiscent American or European patients. Here, we performed whole-exome sequencing genomic DNA 191 tumor non-cancerous adjacent tissue pairs obtained 97 American, 69 2 Asian 23 Kenyan Our analysis data revealed elevated mutational burden both patients, when...
Abstract The association between fatty acids and prostate cancer remains poorly explored in African-descent populations. Here, we analyze 24 circulating 2934 men, including 1431 cases 1503 population controls from Ghana the United States, using CLIA-certified mass spectrometry-based assays. We investigate their associations with groups (Ghanaian, African American, European American men), lifestyle factors, acid desaturase ( FADS ) genetic locus, cancer. Blood levels of vary significantly...
Diabetes commonly affects patients with cancer. We investigated the influence of diabetes on breast cancer biology using a 3-pronged approach that included analysis orthotopic human tumor xenografts, patient tumors, and cells exposed to diabetes/hyperglycemia-like conditions. aimed identify shared phenotypes molecular signatures by investigating metabolome, transcriptome, mutational burden. hyperglycemia did not enhance cell proliferation but induced mesenchymal stem cell-like linked...
The double stranded RNA binding protein Adad1 (adenosine deaminase domain containing 1) is a member of the adenosine acting on RNAs (Adar) family with germ cell-specific expression. In mice, necessary for sperm differentiation, however its function outside mammals has not been investigated. Here, through an N-ethyl-N-nitrosourea (ENU) based forward genetic screen, we identified adad1 mutant zebrafish line that develops as sterile males. Further histological examination revealed complete lack...
Abstract Background: Chronic life stress is more prevalent in low socioeconomic status (SES) communities and has been shown to affect DNA methylation the immune system. Yet, biological processes that mediate impact of SES on health promote development chronic diseases like cancer remain poorly understood. Previous studies have individuals from disadvantaged neighborhoods experience a disproportionate amount both chemical non-chemical stressors, addition epigenetic alterations such as histone...
Abstract Diabetes commonly affects cancer patients. In breast cancer, it decreases patient survival. also impacts African American women more so than European women, potentially contributing to the health disparity. this study, we investigated influence of diabetes on biology in a diverse cohort using three-pronged approach that included analysis orthotopic human tumor xenografts, tumors, and cells exposed diabetes/hyperglycemia-like conditions. We aimed identify shared phenotypes molecular...
<p>Supplementary Figure 2 shows the distribution of immune cell types in breast tumors.</p>
<p>Supplementary Figure 1 shows the effect of acquired FOXA1 somatic mutations on breast cancer survival.</p>
<p>Mutational signatures in breast tumors and their association with somatic mutations driver genes immune cell signatures. <b>A,</b> Prevalence of mutational from the COSMIC catalog (SBS1–3, 5, 13, 18) AA, Kenyan, EA patients. Others include 2 AA 6 patients self-reported Hispanic ethnicity. <b>B,</b> Elevated presence SBS3 signature Relative abundance scores for each tumor were compared between three patient group (one-way ANOVA, <i>P</i> <...
<p>Supplementary Figure 3 shows mutational signatures in breast tumors and their association with somatic mutations driver genes immune cell signatures.</p>
<p>Pattern of somatic mutations among AA and EA patients. <b>A,</b> Genes enriched with showing robust frequency differences or exclusivity in patients breast cancer. <i>FOXA1</i> mutation is shown as comparison. Only those who carried at least one these are included this graph. <b>B,</b> Mutational spectra <i>TP53</i> (top) <i>FBXW7</i> (bottom) tumor suppressor genes the TCGA dataset. <b>C,</b> GSEA KEGG gene set...
<p>Supplementary Figure 2 shows the distribution of immune cell types in breast tumors.</p>
<p>Supplementary Figure 4 shows neighborhood deprivation as a determinant of breast cancer survival in the NCI-Maryland cohort.</p>
<p>Mutational signatures in breast tumors and their association with somatic mutations driver genes immune cell signatures. <b>A,</b> Prevalence of mutational from the COSMIC catalog (SBS1–3, 5, 13, 18) AA, Kenyan, EA patients. Others include 2 AA 6 patients self-reported Hispanic ethnicity. <b>B,</b> Elevated presence SBS3 signature Relative abundance scores for each tumor were compared between three patient group (one-way ANOVA, <i>P</i> <...
<div>Abstract<p>Women of African descent have the highest breast cancer mortality in United States and are more likely than women from other population groups to develop an aggressive disease. It remains uncertain what extent Africa is reminiscent American or European patients. Here, we performed whole-exome sequencing genomic DNA 191 tumor non-cancerous adjacent tissue pairs obtained 97 American, 69 2 Asian 23 Kenyan Our analysis data revealed elevated mutational burden both...
<p>Mutational profiles in breast tumors according to ancestral background of the patients. <b>A,</b> Circos admixture plot showing proportions West African, European, and Asian ancestry (outer circle) self-identified AA (blue, inner circle, <i>n</i> = 97), EA (bisque, 69), American (bronze, 2) patients with cancer NCI-Maryland study. shows estimates derived from tumor/normal tissue pairs. <b>B,</b> TMB primary (<i>n</i> 96), Kenyan 23)....
<p>Supplementary Figure 5 shows neighborhood deprivation and its association with mutational signatures.</p>
<p>Supplementary Figure 1 shows the effect of acquired FOXA1 somatic mutations on breast cancer survival.</p>