A5067988189- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Liver Disease Diagnosis and Treatment
- Meat and Animal Product Quality
- Diet and metabolism studies
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Spectroscopy and Chemometric Analyses
- Endoplasmic Reticulum Stress and Disease
- Ion Transport and Channel Regulation
- Optical Network Technologies
- Microbial Inactivation Methods
- Obesity and Health Practices
- Obesity, Physical Activity, Diet
- Advanced Biosensing Techniques and Applications
- Bariatric Surgery and Outcomes
- Biodiesel Production and Applications
- Body Contouring and Surgery
- Advanced Photonic Communication Systems
- Nutritional Studies and Diet
- Cardiovascular Disease and Adiposity
- Lipid metabolism and disorders
- Advanced Optical Network Technologies
- Eating Disorders and Behaviors
Clinica Universidad de Navarra
2015-2023
Navarre Institute of Health Research
2022
Instituto de Salud Carlos III
2017-2022
Universidad de Navarra
2018-2019
Universidad Publica de Navarra
2019
Centro de Investigación Biomédica en Red
2018
European Association for the Study of Obesity
2017
Human obesity is associated with increased circulating TNF-α, a proinflammatory cytokine that induces hepatocyte cell death. The potential beneficial effects of acylated and desacyl ghrelin in the progression nonalcoholic fatty liver disease (NAFLD) to steatohepatitis via inhibition TNF-α–induced apoptosis, autophagic death, pyroptosis were investigated. Plasma isoforms TNF-α measured 158 participants, death was evaluated biopsies from 76 patients morbid undergoing bariatric surgery...
Abstract Bariatric surgery improves non-alcoholic fatty liver disease (NAFLD). Our aim was to investigate the potential role of ghrelin isoforms in resolution hepatic steatosis after sleeve gastrectomy, a restrictive bariatric procedure, diet-induced obese rats. Male Wistar rats (n = 161) were subjected surgical (sham operation and gastrectomy) or dietary interventions [fed ad libitum normal (ND) high-fat (HFD) diet pair-fed]. Obese developed hepatosteatosis showed decreased circulating...
Abstract Background Growing evidence suggests the key role of ghrelin in onset and progression nonalcoholic fatty liver disease (NAFLD). The potential participation receptor antagonist, LEAP-2, fibrosis patients with severe obesity NAFLD through regulation TGF-β1-induced hepatic stellate cell (HSC) activation was investigated. Methods Circulating (n = 179) expression 95) LEAP-2 were measured available pathology analysis undergoing Roux-en-Y gastric bypass (RYGB). effect isoforms on HSC...
One might expect that a perception of obesity being risk factor and disease, contributes to effective prevention management strategies. However, rates continue increase worldwide. The question arises whether is truly perceived as disease. This paper aims at describing disease among individuals seeking care, not the society, different professionals having role in field obesity. reflection lecture on topic was given EASO's New Investigators United's Summer School 2016 Portugal discussion with...
Biomechanical properties of adipose tissue (AT) are closely involved in the development obesity-associated comorbidities. Bariatric surgery (BS) constitutes most effective option for a sustained weight loss addition to improving metabolic diseases including type 2 diabetes (T2D). We aimed determine impact achieved by BS and caloric restriction (CR) on biomechanical AT. but not CR changed epididymal white AT (EWAT) from diet-induced obesity rat model, which were associated with improvements....
Angiopoietin-like protein 8 (ANGPTL8) is an hepatokine altered in several metabolic conditions, such as obesity, type 2 diabetes, dyslipidemia and nonalcoholic fatty liver disease (NAFLD). We sought to explore whether ANGPTL8 involved NAFLD amelioration after bariatric surgery experimental models patients with severe obesity. Plasma was measured 170 individuals before 6 months surgery. Hepatic expression evaluated biopsies of obesity undergoing available pathology analysis (n = 75), well...
This study assesses the physicochemical and microbiological stability of Duroc ham slices over a long-term storage (8 months) under various conditions. Thus, three treatments were designed: T4ºC; refrigerated (4ºC ± 1) non-pressurised vacuum packages; T20ºC; not pressurised packages stored at 20ºC 2 high hydrostatic pressure (HHP) + pressurized (600 MPa for 8 minutes) 2. Storage 20°C led to higher decrease in lightness time lower γ-tocopherol polyunsaturated fatty acid values from 3 months...
We evaluate the performance of coherent optical communications systems using hybrid spans, composed quasi-single-mode (QSM) and single-mode fibers (SMFs). study how optimum fiber splitting ratio per span increases with length, QSM effective area, residual multipath interference at receiver.