A5074465312- Protein Hydrolysis and Bioactive Peptides
- Biochemical effects in animals
- Insect Utilization and Effects
- Proteins in Food Systems
- Consumer Attitudes and Food Labeling
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Meat and Animal Product Quality
- Cancer Risks and Factors
- Hedgehog Signaling Pathway Studies
- GDF15 and Related Biomarkers
- Probiotics and Fermented Foods
- Nutrition, Genetics, and Disease
- Cancer Research and Treatments
- Natural Compounds in Disease Treatment
- Food composition and properties
- Allergic Rhinitis and Sensitization
- Helicobacter pylori-related gastroenterology studies
- Food Allergy and Anaphylaxis Research
- Cardiac, Anesthesia and Surgical Outcomes
- Infant Nutrition and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle metabolism and nutrition
- Mechanical Circulatory Support Devices
- Cancer Cells and Metastasis
University of Nebraska–Lincoln
2017-2025
R. G. Kar Medical College and Hospital
2024
Medical College and Hospital, Kolkata
2024
Indian Institute of Technology Bombay
2020-2022
Indian Institute of Chemical Biology
2022
University of Minnesota
2014-2021
University of Guelph
2015-2020
University of Alberta
2009-2019
Centro de Investigación en Alimentación y Desarrollo
2019
Kunming University of Science and Technology
2019
Egg protein ovotransferrin derived peptides (IRW and IQW) can attenuate tumor necrosis factor (TNF) induced inflammatory responses oxidative stress in endothelial cells. The present study investigates the structural requirements molecular mechanisms underlying these events. Whereas IRW significantly inhibited TNF-induced up-regulation of intercellular cell adhesion molecule-I (ICAM-1) vascular (VCAM-1), IQW could inhibit only ICAM-1. anti-inflammatory effects appeared to be mediated by...
Background There is a growing interest in using functional food components as therapy for cardiovascular diseases such hypertension. We have previously characterized tri-peptide IRW (Ile-Arg-Trp) from egg white protein ovotransferrin; this peptide showed anti-inflammatory, anti-oxidant and angiotensin converting enzyme (ACE) inhibitor properties vitro. Given the pathogenic roles played by angiotensin, oxidative stress inflammation spontaneously hypertensive rat (SHR), we tested therapeutic...
In this study, walnut meal hydrolysates (WMH) and dephenolized (DWMH) were found to effectively decrease the serum uric acid level protect renal function in potassium oxonate-induced hyperuricemic rats vivo as well inhibit xanthine oxidase vitro. Two novel antihyperuricemic peptides including WPPKN (640.8 Da) ADIYTE (710.7 purified from DWMH via Sephadex G-15 gel filtration reverse-phase high-performance liquid chromatography identified by LC-ESI-MS/MS. These displayed high vitro inhibition...
Ovotransferrin is a glycoprotein well-known for its iron-binding property. was reported to have antioxidative properties, but the presence of antioxidant peptides within protein has not been reported. The purpose study characterize ovotransferrin. sonicated and hydrolyzed by thermolysin, from hydrolysate were fractionated ion-exchange fast liquid chromatography reversed-phase high-performance chromatography. Fourteen derived ovotransferrin characterized using LC-MS/MS, their oxygen radical...
Egg proteins are an excellent source of bioactive peptides. The purpose this work was to study the effect cooking methods on production angiotensin converting enzyme (ACE) inhibitory Boiled or fried eggs (in forms whites, yolks, and whole eggs) were digested by gastrointestinal tract proteases at simulated gut conditions. Fried egg digests showed more potent activity than those boiled digests; digest had IC50 value 0.009 mg protein/mL. This hydrolysate further purified cation exchange...
Oxidative stress and vascular inflammatory response are key mediators of endothelial dysfunction that leads to cardiovascular diseases. A novel peptide, IRW, was previously characterized from egg protein with angiotensin converting enzyme inhibitory activity. The purpose the study investigate effects molecular mechanisms IRW on regulating in cells. results showed tumor necrosis factor-α (TNF-α) significantly increased levels intercellular adhesion molecule-1 (ICAM-1), cell (VCAM-1), monocyte...
Fear of diabetes and major surgery may prohibit referral young children severely affected by pancreatitis for total pancreatectomy with islet autotransplant (TPIAT). We evaluated outcomes in our youngest TPIAT recipients, 3 to 8 years age at surgery.Medical records were reviewed 17 (9 girls) ages or younger undergoing from 2000 2014. Most (14/17) had genetic risk factors pancreatitis. Since 2006, recipients followed prospectively health questionnaires including assessments pain narcotic use,...
Egg ovotransferrin-derived angiotensin converting enzyme (ACE) inhibitory peptide IRW was previously shown to reduce blood pressure in spontaneously hypertensive rats through reduced vascular inflammation and increased nitric oxide-mediated vasorelaxation. The main objective of the present study investigate molecular mechanism this transcriptome analysis by RNAseq technique.Total RNA extracted from kidney mesenteric arteries; libraries (from untreated IRW-treated groups) were constructed...
Angiotensin converting enzyme (ACE) inhibitory peptides from egg have demonstrated reduction of blood pressure (BP) in vivo. In this study we evaluated the effects white hydrolysate (EWH) prepared by thermolysin and pepsin spontaneously hypertensive rats (SHRs). Fourteen to sixteen week old SHRs were implanted with telemetry devices. After recovery, divided randomly into three groups: untreated, EWH low dose (250 mg/kg BW), high (1000 BW) for 12 days. BP showed a significant group compared...
Posttranslational N-glycosylation of food proteins plays a critical role in their structure and function. However, the N-glycoproteome chicken egg yolk (CEY) has not been studied yet. Glycopeptides hydrolyzed from CEY were enriched, with deglycosylation occurring using PNGase F, then identified shotgun glycoproteomics strategy. A total 217 sites 86 glycoproteins CEY, these are mainly involved binding, biological regulation, catalytic activity, metabolic processes. Among glycoproteins, 22...