A5087851907- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Cytomegalovirus and herpesvirus research
- Bacterial Identification and Susceptibility Testing
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Hemodynamic Monitoring and Therapy
- COVID-19 epidemiological studies
- Orthopedic Infections and Treatments
- Helicobacter pylori-related gastroenterology studies
- Nail Diseases and Treatments
- E-Learning and Knowledge Management
- Infectious Diseases and Tuberculosis
- Plant Pathogens and Fungal Diseases
- Gut microbiota and health
- Cystic Fibrosis Research Advances
- Long-Term Effects of COVID-19
- Infections and bacterial resistance
Deenanath Mangeshkar Hospital and Research Center
2020-2024
The University of Texas MD Anderson Cancer Center
2016
The University of Texas Health Science Center at Houston
2016
Invasive candidiasis is a serious infection seen in hospitalized or immunocompromised patients. Mortality rates for candidemia can be as high 30-60%. Candida auris an emerging species of and increasingly becoming global public health problem.This was retrospective observational study, which we analyzed 79 episodes candidemia. Blood cultures were done using the Bactec™ FX blood culturing instrument (Becton, Dickinson Company Sparks, Maryland, USA). Species identification VITEK® 2 YST panels...
Though echinocandins are the first line of therapy for C. auris candidemia, there is little clinical data to guide choice within this class. This was study compare three in terms efficacy and outcomes candidemia. a retrospective analysis 82 episodes candidemia caused by comparing across echinocandins. Majority patients our were treated with micafungin. Susceptibility rates lowest caspofungin (35.36% resistance), no resistance reported other two When susceptible echinocandin chosen, not...
Khilnani GC, Tiwari P, Mittal S, Kulkarni AP, Chaudhry D, Zirpe KG,
Gram-negative sepsis remains one of the most difficult to treat infections in intensive care units (ICUs). Carbapenems are often considered be robust and reliable options for treating due bacteria. The dominance carbapenem-resistant enterobacteriaceae (CRE) has emerged as greatest challenges faced by medical community today. Carbapenem-resistant may resistant all beta lactam antimicrobials including carbapenems often, even other classes drugs. There limited studies comparing polymyxin-based...
Objectives: Fecal microbiota transplantation (FMT) is an emerging option for recurrent or refractory Clostridium difficile-associated diarrhea (CDAD).We describe a single-center experience of FMT in hematopoietic stem cell transplant (HSCT) recipients with CDAD India.Methods: A prospective observational study HSCT who received our center.Results: total 13 patients were included.All the allogenic recipients; was performed seven due to CDAD, five presence both and graft vs host disease (GVHD),...
Abstract Background Data on mixed mould infection with COVID‐19‐associated pulmonary aspergillosis (CAPA) and mucormycosis (CAPM) are sparse. Objectives To ascertain the prevalence of co‐existent CAPA in CAPM (mixed infection) whether is associated early mortality (≤7 days diagnosis). Methods We retrospectively analysed data collected from 25 centres across India mucormycosis. included only excluded subjects disseminated or rhino‐orbital defined if a respiratory specimen showed septate...
India is facing the pandemic of coronavirus disease (COVID-19) just like whole world. The private sector backbone a healthcare facility in India. Presently, only few major hospitals country are actively dealing with COVID-19 patients while others troubles due to lack manpower, management, and required experience face pandemic. Despite lockdown, cases ever increasing each every hospital should be prepared this world has never seen before. As one largest multispecialty designated COVID center,...
Objectives: To describe the demographics and evaluate clinical outcomes of hypoxic coronavirus disease-2019 (COVID-19) patients treated with different immunomodulatory (IM) drugs in a resource-limited setting. Materials methods:We conducted retrospective cohort study these admitted to our hospital between March 22 May 31, 2020.Data were abstracted from multiple electronic data sources or patient charts provide information on characteristics, clinical, laboratory variables, outcomes.Results:...
There has been an increase alarming rise in invasive mycoses during COVID-19 pandemic, especially the second wave.Compare incidence of last three years and study risk factors, manifestations outcomes COVID era.Multicentric was conducted across 21 centres a state western India over 12-months. The clinico-radiological, laboratory microbiological features, treatment patients were studied. We also analysed yearly rhino-orbito-cerebral mycosis.There more than five-times compared to previous...
Dear Editor, A large number of mucormycosis cases were reported in India following the second wave COVID-19.[1] However, data on imaging appearance COVID-19-associated pulmonary (CAPM) are limited.[2] few published case reports CAPM and a systematic literature review suggested cavity consolidation as most common finding.[3-6] The primary objective current study was to describe computed tomography (CT) thorax findings at diagnosis. secondary objectives compare CT (1) patients with diabetes...
Candida auris is emerging as an important cause of candidemia and deep seated candidal infection. We compared the susceptibility results bloodstream isolates by Vitek 2 with Sensititre YeastOne (SYO) method. Forty-seven C. blood stream were simultaneously tested for AFST SYO. All strains resistant to Fluconazole. 25.5% showed pan-azole resistance. In comparison SYO, lower MICs voriconazole noted (VME rate 76.1%). sensitive anidulafungin micafungin For micafungin, demonstrated higher ME...
Isavuconazole is an emerging therapeutic option for invasive infections caused by molds, especially aspergillosis and mucormycosis. has predictable pharmacokinetics good bioavailability. These attributes have led to some doubts regarding the need drug monitoring (TDM). There are no data from India TDM isavuconazole.A retrospective analysis of 50 patients who received oral isavuconazole purposes. Plasma levels were measured using a reversed phase high-performance liquid chromatography (HPLC)...
Introduction:In the Indian setting, antimicrobial resistance in A. baumannii is a considerable problem, especially intensive care units (ICUs).Due to limited data, clinicians are left with very few choices except polymyxins for treating serious infections caused by baumannii.There sparse data regarding local mechanisms of resistance.Given current therapeutic challenges, it critical know enzymatic patterns and antibiograms.Materials methods: A retrospective analysis 50 episodes bacteremia...
A 65-year-old man, an avid duck hunter presented for management of newly diagnosed AML (acute myeloid leukemia). One week before, he developed pruritus and erythema on his left leg after recently walking through tall grass in Louisiana wetlands. He a "black spot" ulcer the center worsening erythematous area. Physical examination by local physician revealed painful ulcerated lesion over lower extremity with central black eschar (Fig. 1A). Initial peripheral blood workup 33% blasts...
Posaconazole is a broad-spectrum triazole antifungal, with activity against various clinically important fungi. The delayed release (DR) tablet of posaconazole has been shown to have superior pharmacokinetic profile in comparison the oral suspension.We retrospectively analyzed factors associated levels <1.25 μg/ml 164 patients receiving DR for therapeutic purposes.Of patients, 53 (32.3%) showed subtherapeutic trough posaconazole. use proton pump inhibitors (95% CI 1.41-3.91; P-value = 0.028)...
There is limited real-world data from India examining the treatment characteristics, safety, and efficacy of ceftazidime-avibactam against Gram-negative organisms especially multidrug-resistant pathogens including Carbapenem-Resistant Enterobacterales Pseudomonas. In this retrospective study, patterns, effectiveness, safety in treating Gram- negative infections were assessed. Data was extracted electronic health records adult patients admitted to hospital with documented infection who had...
There is limited real-world data from India examining the treatment characteristics, safety, and efficacy of ceftazidime-avibactam against Gram-negative organisms especially multidrug-resistant pathogens including carbapenem-resistant
How to cite this article: Prayag PS. Author Reply: Therapeutic Drug Monitoring of Isavuconazole: Lessons Learnt from a Real-life Setting in Tertiary Care Center India. Indian J Crit Med 2023;27(6):451.