Abstract We conducted a study on the impact of intraperitoneal injections melatonin and its three bioisosteres (compounds 1 – 3 ) development oxygen‐induced retinopathy in newborn rats during 21‐day experiment. It was demonstrated that analogues effectively reduce total protein concentration vitreous body rat pups, decrease VEGF‐A, lower level oxidative stress (as indicated by normalization antioxidant activity body). Melatonin equally normalize VEGF‐A. Analogues 2 even exceed their ability...

AIM: The study aimed to analyze the influence of various factors on efficiency trabeculectomy in pediatric patients with congenital glaucoma. MATERIAL AND METHODS: results 945 trabeculectomies, including those modifications and use drains, glaucoma were analyzed Department Pediatric Eye Pathology Helmholtz National Medical Research Center for Diseases 1997–2023. RESULTS: was 91.9%–98.5% immediate period (up 6 months) after surgery, 75.5%–86.5% long term (after 5 years), 34.2%–42.1% repeated...

In a rat model of experimental retinopathy prematurity (ROP), the safety enalaprilat and its effect on level angiotensin-converting enzyme (ACE) angiotensin-II (AT-II) in vitreous body retina were investigated. The study was performed 136 newborn Wistar pups divided into 2 groups: group A - (animals with ROP, n=64) B control (n=72). Each further subgroups: A0 B0 (n=32 n=36, respectively) animals that did not receive injections enalaprilat, A1 B1 treated daily intraperitoneal (i.p.) (0.6...

The multifactorial nature of the retinopathy prematurity (ROP) pathogenesis, makes thorough study mechanism pathological retinal neovascularization actual. However recently attention scientists has been attracted by participation renin-angiotensin system (RAS) in development vasoproliferative diseases. Purpose: to role AT-II pathogenesis experimental ROP (EROP) original model disease. Material and methods. To reproduce EROP Wistar rats (n = 15) were exposed oxygen concentration varying from...

Ulcerative lesions of the cornea and graft in children are a serious problem pediatric ophthalmology, leading to consequences, up anatomical death eye. The effective treatment this pathology corneal tissue regeneration remains relevant, despite large arsenal drugs. Recently, ultraviolet (UVA) collagen crosslinking has been proposed as an alternative for ulcers adults. RASK-CXL is official name used exclusively inflammatory diseases. In children, still only keratoconus. We were first use...

Purpose : to assess the level of catecholamines norepinephrine and dopamine in rat retina with experimental retinopathy prematurity (EROP) at a time corresponding peak neovascularization. Material methods . The study was performed on 41 infant Wistar rats (82 eyes). were divided into 2 groups: group (with EROP, n = 21) control (n 20). In order reproduce newborn placed for 14 days incubator together their mother. Every 12 hours, oxygen concentration ranged from 60 15 %. consisted pups who...

Purpose: to assess the possibility of using thioctic acid and indomethacin tin eyedrops for therapy early stages retinal neurodegeneration. Material methods. The study was performed on 20 Chinchilla rabbits, including 16 rabbits in whom neurodegenerative process retina produced by intravitreal installation 6-hydroxydopamine (6-OHDA), 0.25 mg per eye, 4 (8 eyes) served as control. Thioctic 0.5% Indocollir 0.1% were instilled separately combination 5 times daily 7 days after injection 6-OHDA....

This work is dedicated to prove our hypothesis that catecholamines and their metabolites play crucial role in development of retinopathy prematurity, severe disabling fibrovasoproliferative vitreoretinal pathology premature infants. Research was done on experimental model achieved by hyperohygenation rats 7th, 14th, 21st 30th day life. Amount retina measured HPLC with electrochemical detection. It shown L-DOPA life were lowered animals than control noradrenaline 14 th increased control....

Purpose: to evaluate the results of a new combined method for treatment corneal and graft ulcers in preschool children, including local ultraviolet crosslinking (UVA CL) collagen amniotic membrane transplantation (AMT). Methods. 1 patient 4 years old with ulcer transplant disease after penetrating subtotal keratoplasty child 6 herpetic etiology was under observation year. The included 3–5 consecutive procedures UVA CL cornea lasting 5 min. (AMT) first procedure. Biomicroscopy fluorescein...

Preliminary data show that the incidence of eye damage in COVID-19 reaches 32%, with a diverse range clinical manifestations. Both anterior segment (conjunctivitis, keratoconjunctivitis) and posterior (retinal vascular thrombosis, neuritis, neuroretinitis) can be affected. The infection children is diagnosed much less frequently than adults, so ophthalmic manifestations have hardly ever been studied. Purpose : to present cases congenital lesions born mothers who had during pregnancy....

Purpose : to determine the incidence and clinical course of retinopathy prematurity (ROP) in modern developmental care conditions as based by data a level III perinatal center. Material methods . A retrospective study 920 premature infants ROP at-risk cohort managed Neonatology department Moscow Regional Perinatal Center over 2-year period 2017–2018 was performed. Retinopathy graded treated following respective Federal guidelines. Results Of who met screening criteria, detected 193 (28.5 %)...

Retinopathy of prematurity is the main cause visual impairment and blindness in infants with low birth weight preterm gestational age, spite achievements neonatology wide applying diagnostic treatment guidelines. The pathogenetic role VEGF determined course normal angiogenesis retinopathy prematurity. Scientists continue search another significant vasoprolifirative factors methods how to inhibit them. This review devoted monoamines’ angiogenesis. for relevant literature was carried out using...

Purpose : to analyze clinical and functional manifestations the course of different stages primary congenital glaucoma (CG) at times disease onset, using data admissions Department Eye Pathology in Children Helmholtz Research Center Diseases. Material methods. 191 patients (320 eyes) with CG, which 113 were children (191) eyes (PCG) aged 1 month 16 years, underwent standard ophthalmological examination (autorefractometry, visometry, biomicroscopy, ophthalmoscopy), electrophysiological (flash...

AIM: This study aimed to investigate the efficacy and safety of micropulse cyclophotocoagulation (MP-CPC) in treatment various types glaucoma children.
 MATERIAL AND METHODS: The included 14 children (15 eyes) with uncompensated etiologies, who underwent MP-CPC using Cyclo G6 laser system (IRIDEX, USA). intervention was considered absolutely effective when IOP reached 8 25 mm Hg without medications signs progression glaucoma, relatively effective, same criteria are achieved hypotensive...

Background: Biological agents (BA), especially TNF inhibitors, are high efficacy options for current therapy patients (pts) with juvenile idiopathic arthritis (JIA). They successfully used not only the but also JIA-associated uveitis, however, development of uveitis de novo in pts treated BA is a well-established paradoxical phenomenon. Objectives: to evaluate frequency new onset ( no -) occurring under JIA pts, establish clinical features, which may be associated such effects. Methods:...

Despite dominant lung lesions, new coronavirus infection (COVID-19) can influence almost any organ, including eyes. According to modern data, frequency of eye damage by COVID-19 reaches 32%, and spectrum clinical manifestations is diverse. Changes are observed both in the anterior (mainly conjunctivitis) posterior (mostly retinal vascular thrombosis, optic neuritis, neuroretinitis) segments eye, timing their occurrence varies from first (sometimes only) symptoms disease development at peak...

Background: The efficiency of treatment and prevention retinopathy prematurity (ROP) has improved. In addition, the development a disease screening system to reduce incidence disability resulting from this pathology is important.
 Aim: This study aimed determine new laboratory criteria for predicting ROP course through in-depth investigation molecules participating in pathogenesis ROP.
 Material methods: A comprehensive clinical experimental was performed assess local systemic...

AIM: This study aimed to evaluate the clinical features of internal fistula obliteration after trabeculectomy (TE) in children with congenital glaucoma and possibility laser treatment.
 MATERIAL AND METHODS: The included 73 eyes 56 who underwent TE between 3 months 16 years. Yttrium aluminum garnet (YAG) refistulization was performed postoperatively because gonioscopy results revealed a complete or partial block fistula. In addition, patented technique utilized that combines use...

Purpose : to determine the role of systemic angiotensin II (AT-II) in pathogenesis retinopathy prematurity (ROP) and assess its prognostic value. Material methods . 34 premature infants at risk developing ROP were examined according ophthalmological screening protocol adopted Russian Federation. Retrospectively, divided into 2 groups: those without (n = 15) with developed 19). The average gestational age was 28.12 ± 0.64 weeks, their body weight birth 1164 118.6 g. respective values for...

Congenital aniridia is a hereditary congenital malformation of the visual organ with an autosomal dominant type inheritance. The prognosis for vision largely depends on development and progression multiple complications (glaucoma, keratopathy, fibrotic syndrome) at different ages.
 AIM: To identify most significant risk factors glaucoma poor associated aniridia.
 MATERIAL AND METHODS: Seventy-three children (146 eyes) PAX6-associated aged 016 yr were examined, 41 males (56.2%) 32...

Purpose : to analyze morphometric, clinical and functional manifestations of glaucomatous optical neuropathy in congenital childhood glaucoma (CG). Material methods . We examined 103 children (163 eyes) with (CG), including 54 (86 primary (PCG) aged 1 month 17 years. In addition the regular ophthalmological examination, we performed coherence tomography optic nerve head (ONH), flash visual evoked potentials, total rhythmic electroretinogram, oscillatory potentials (OP), echobiometry eye...

Congenital corneal opacities (CCO) are rare eye anomalies of various etiological causes. Given the heterogeneity clinical and morphological manifestations CCO, its functional disorders same type significant, leading to visual disability. This anomaly occurs in 6 per 100,000 newborns.
 AIM: To study anatomical features treatment results CCO children aged under 3 years old, who were treated Department Eye Pathology Children Helmholtz National Medical Research Center Diseases for period...

Background: Juvenile Idiopathic Arthritis (JIA) is heterogeneous group of diseases which may include genetically determined conditions. Extremely rare monogenic hereditary autoinflammatory disease, such as Blau syndrome (BS) usually difficult to recognize and JIA initially established. BS caused by a mutation in the NOD2/CARD5 gene phenotypically characterized triad granulomatosis polyarthritis, uveitis skin rash. Objectives: To present family case confirmed 2 siblings, diagnosed patients...

AIM: On the basis of studying causes errors in finding trabecular zone to be excised during trabeculectomy children with congenital glaucoma, this study presents a proven and effective method for simple intraoperative localization area.
 MATERIAL AND METHODS: The analyses many years experience examination treatment glaucoma at Department Eye Pathology Children Helmholtz National Medical Research Center (100200 annually) revealed anatomical morphological features eyes reasons...