A5009496271- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Renal Transplantation Outcomes and Treatments
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- HIV/AIDS drug development and treatment
- Transplantation: Methods and Outcomes
- SARS-CoV-2 detection and testing
- Systemic Lupus Erythematosus Research
- Cardiac, Anesthesia and Surgical Outcomes
- Pancreatitis Pathology and Treatment
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 and COVID-19 Research
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Genetic and Kidney Cyst Diseases
- Respiratory viral infections research
- Viral-associated cancers and disorders
- Biliary and Gastrointestinal Fistulas
Hospital Universitario Río Hortega
2016-2025
Universidad de Valladolid
2016-2022
Junta de Castilla y León
2021-2022
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2021
Hospital General Universitario De Valencia
2017
Hospital Universitario 12 De Octubre
2017
MaineGeneral Medical Center
2016
Centro de Investigación Biomédica en Red
2015
Hospital Universitario Reina Sofía
2015
Hospital General Universitario Gregorio Marañón
2015
A retrospective cohort multicenter study was conducted to analyze the risk factors for tumor recurrence after liver transplantation (LT) in cirrhotic patients found have an intrahepatic cholangiocarcinoma (iCCA) on pathology examination. We also aimed ascertain whether there existed a subgroup of with single tumors ≤2 cm ("very early") which results LT can be acceptable. Twenty-nine comprised group, eight whom had "very early" iCCA (four them incidentals). The significantly associated larger...
To evaluate the outcome of patients with hepatocellular-cholangiocarcinoma (HCC-CC) or intrahepatic cholangiocarcinoma (I-CC) on pathological examination after liver transplantation for HCC.Information cirrhotic undergoing a transplant HCC and diagnosis HCC-CC I-CC by study is limited.Multicenter, retrospective, matched cohort 1:2 study.42 study; control group: 84 HCC. subgroup: 27 compared 54 controls; 15 30 controls. Patients were also divided according to preoperative tumor size number:...
Graphical Abstract
The number of patients awaiting liver transplantation (LT) in Spain has halved from 2015 to 2019 due the reduction candidates with hepatitis C and successful implementation nonheart beating donation programs across country. Spanish Society for Liver Transplantation committed take advantage this situation by developing consensus around potential areas expand current indications LT. group was composed 6 coordinators 23 expert delegates, each one representing an LT institution Spain.A modified...
Background/Objectives: Data on the natural history and endoscopic treatment outcomes of recurrent anastomotic biliary stricture (RABS) after orthotopic liver transplantation (OLT) are limited. This study aimed to evaluate incidence RABS OLT. Methods: A retrospective single-center OLT patients who underwent successful ABS was conducted. The RABS, risk factors for recurrence, repeat therapy were recorded. Results: total 131 with treatment, which 119 successfully completed an course. After a...
Hepatitis C virus causes significant morbidity and mortality worldwide. The infection induces up-regulation of cytokine chemokines commonly linked to the development cellular pro-inflammatory antiviral responses. current standard in hepatitis treatment consists combination regimens pegylated interferon-alpha plus ribavirin. impact combined host immune response is still poorly understood. In present study, we profiled 27 cytokines, growth factors involved innate adaptive responses serum...
Interferon-free therapies have an improved safety and efficacy profile. However, data in elderly patients, who frequently advanced liver disease, associated comorbidities, use concomitant medications are scarce. The im of this study was to assess the effectiveness tolerability all-oral regimens patients real-life clinical practice.Retrospective analysis hepatitis C virus (HCV) aged ≥65 years receiving interferon-free within Spanish National Registry (Hepa-C).Data 1,252 were recorded. Of...
Objective: the aim of our study was to examine, in a prospective way, whether any nutritional parameter could predict outcomes after liver transplantation.Material and subjects: assessment performed 31 consecutive patients six months prior undergoing orthotopic transplantation (OLT) at single center (Hospital U. Río Hortega) OLT (December 2002-June 2004).The evaluation included Subjective Global Assessment (SGA), Mini Nutritional test (MNA), anthropometry, laboratory tests, three-day diet...
of stones.Traditionally, it was considered a fatal disease almost exclusively critical ill patients; however, there are recent reports cases AAC affecting less severe patients with good prognosis treated antibiotics, in the absence cholecystectomy.We herein report case young man who developed after Salmonella enteritidis gastrointestinal infection. CASE REPORTA 27-year-old admitted to hospital abdominal pain, diarrhoea, persistent vomiting and 38℃ temperature.On physical examination, he...
The aim of this study was to evaluate the impact a steroid-free regimen with tacrolimus and mycophenolate mofetil (modified therapy) vs. standard steroids on cardiovascular risk score liver transplant recipients. Patients who received were randomized modified therapy (n = 58) or 59). Both groups balanced at baseline, except for higher prevalence diabetes mellitus (DM) (p < 0.01) serum creatinine concentration 0.05) in group. After 12 months, new-onset DM, arterial hypertension,...
Abstract Background & Aims (i) To describe the demographic, clinical, virological and histological characteristics of patients undergoing evaluation for indication triple therapy against hepatitis C virus genotype 1, to identify reasons why candidate are excluded; (ii) evaluate healthcare environment related treatment. Methods Observational, prospective multi‐centred study involving 16 hospitals Spain. Data were collected on 1122 receiving attention in outpatient clinics between June...
The influence of cytomegalovirus (CMV) on recurrent hepatitis C virus (HCV) in liver grafts is controversial. Our aim was to investigate the association between CMV infection and disease severe HCV recurrence (composite variable presence stage 3 4 fibrosis, need for retransplantation or death due disease) first year after transplantation.An observational, prospective, multicenter study performed. replication monitored by determining viral load weekly during hospitalization transplantation,...
The role of systemic immunity in the pathogenesis cirrhosis is not fully understood. Analysis transcriptomic profiles blood an easy approach to obtain a wide picture immune response at level. We studied gene expression from thirty cirrhotic patients and compared them against those eight healthy volunteers. Most our were male [n = 21, 70%] their middle ages [57.4 ± 6.8 yr]. Alcohol abuse was most frequent cause (n 22, 73%). Eleven had hepatocellular carcinoma (36.7%). Eight suffered hepatitis...
Hepatitis C (HCV) therapy with Sofosbuvir (SOF)/Simeprevir (SMV) in clinical trials and real-world practice, showed high rates of sustained virological response (SVR) non-cirrhotic genotype (GT)-1 GT-4 patients. These results were slightly lower cirrhotic We investigated real-life effectiveness safety SOF/SMV or without ribavirin (RBV) a large cohort patients.This collaborative multicentre study included data from 968 patients cirrhosis infected HCV-GT1 4, treated SOF/SMV±RBV 30 centres...