A5075610725- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- HIV/AIDS drug development and treatment
- Systemic Lupus Erythematosus Research
- Hepatitis Viruses Studies and Epidemiology
- Liver Diseases and Immunity
- Gastrointestinal Tumor Research and Treatment
- Chronic Lymphocytic Leukemia Research
- Anesthesia and Neurotoxicity Research
- Tracheal and airway disorders
- Parasitic infections in humans and animals
- Airway Management and Intubation Techniques
- Trauma Management and Diagnosis
- Gastrointestinal disorders and treatments
- COVID-19 diagnosis using AI
- Renal Diseases and Glomerulopathies
- Anesthesia and Sedative Agents
- Pancreatic and Hepatic Oncology Research
- Glycogen Storage Diseases and Myoclonus
- Lipid metabolism and disorders
- Neurogenetic and Muscular Disorders Research
- Renal Transplantation Outcomes and Treatments
Hospital Virgen de la Salud
2006-2021
Complejo Hospitalario Universitario de Toledo
2014-2019
Hospital Universitario de Toledo
2017-2018
Hospital Clínico Universitario de Valladolid
2018
Hospital Clínic de Barcelona
2017
Universitat de Barcelona
2017
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2017
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2017
Hospital General Universitario De Valencia
2017
ProMedica Toledo Hospital
2016
Introduction and objectives: presently, the reference staging system to evaluate prognosis of hepatocellular carcinoma (HCC) patients is "The Barcelona Clinic Liver Cancer" (BCLC) system.The value alpha-fetoprotein (AFP) has not been properly defined.The aim this study was BCLC classification in our clinical practice know what prognostic AFP is.Material methods: 136 consecutive HCC were prospectively included study.The diagnosis based on recommendation international guidelines.The studied...
Interferon-free therapies have an improved safety and efficacy profile. However, data in elderly patients, who frequently advanced liver disease, associated comorbidities, use concomitant medications are scarce. The im of this study was to assess the effectiveness tolerability all-oral regimens patients real-life clinical practice.Retrospective analysis hepatitis C virus (HCV) aged ≥65 years receiving interferon-free within Spanish National Registry (Hepa-C).Data 1,252 were recorded. Of...
Summary In randomized controlled trials of patients with chronic HCV infection, elbasvir/grazoprevir ( EBR / GZR ) demonstrated high cure rates and a good safety profile. This study assessed the effectiveness , without ribavirin, in real‐world patient cohort. HEPA ‐C is collaborative, monitored national registry directed by Spanish Association for Study Liver Networked Biomedical Research Centre Hepatic Digestive Diseases. Patients entered into between December 2016 May 2017, treated at...
Background: The myeloid-epithelial-reproductive tyrosine kinase (MERTK) is involved in hepatic steatosis, inflammation, and liver fibrosis. Here we evaluated the association between MERTK rs4374383 single nucleotide polymorphism (SNP) fibrosis progression hepatitis C virus (HCV)-infected patients. Methods: We performed a retrospective study (repeated measures design) 208 patients who had stiffness measurement (LSM), which was assessed using transient elastography. No patient cirrhosis at...
Abstract Background and aims CXCL9 ‐ 11 polymorphisms are related to various infectious diseases, including hepatitis C virus (HCV) infection. In this study, we analyzed the association between liver fibrosis in HCV‐infected patients. Methods We performed a cross‐sectional study 389 patients who were genotyped for ( rs10336, CXCL10 rs3921, CXCL11 rs4619915) using Sequenom's MassARRAY platform. The primary outcome variable was stiffness measurement (LSM). established three cut‐offs of LSM:...
Hepatitis C (HCV) therapy with Sofosbuvir (SOF)/Simeprevir (SMV) in clinical trials and real-world practice, showed high rates of sustained virological response (SVR) non-cirrhotic genotype (GT)-1 GT-4 patients. These results were slightly lower cirrhotic We investigated real-life effectiveness safety SOF/SMV or without ribavirin (RBV) a large cohort patients.This collaborative multicentre study included data from 968 patients cirrhosis infected HCV-GT1 4, treated SOF/SMV±RBV 30 centres...
To evaluates the effectiveness and safety of first generation, NS3/4A protease inhibitors (PIs) in clinical practice against chronic C virus, especially patients with advanced fibrosis.Prospective study non-experimental analysis a multicentre cohort 38 Spanish hospitals that includes hepatitis genotype 1, treatment-naïve (TN) or treatment-experienced (TE), who underwent triple therapy generation inhibitors, boceprevir (BOC) telaprevir (TVR), combination pegylated interferon ribavirin. The...
SUMMARY Background Sustained virological response rates of up to 52% have been obtained with peginterferon α2a (40 kDa) plus ribavirin in patients suffering from chronic hepatitis C genotype 1 randomized‐controlled trials. Aim To assess early and its clinical utility predicting an sustained routine practice Spain. Methods Treatment‐naïve received pegylated interferon 180 µg/week 1000/1200 mg/day for 48 weeks, were followed a further 24 weeks. Overall, 475 at least one dose medication...
The management of patients with chronic hepatitis C (CHC) depends on their clinical stage. Thus, noninvasive early recognition CHC at high risk for developing liver-related events (LREs) is important because it ensures optimal preventative strategies may be employed that can affect the course disease. Our aim was to determine whether liver stiffness measurement (LSM) in virus (HCV)-infected associated a LREs, particularly cirrhotic patients. We carried out retrospective study 343...
The polymorphisms at the α-chain of IL-7 receptor (IL7RA) have been related to T-cell homeostasis and development may contribute immune system deregulation. In present study, we analyzed association between IL7RA progression liver fibrosis in patients infected with HCV. We carried out a retrospective study design consisting repeated measurements 187 HCV-infected patients, risk prediction using genetic factors. genotyped rs6897932, rs987106 rs3194051 Agena Bioscience's MassARRAY. Transient...
: The Duffy antigen receptor for chemokines (DARC) rs12075 polymorphism regulates leukocyte trafficking and proinflammatory chemokine homeostasis. Hepatitis C virus (HCV)-mediated liver fibrosis is associated with an uncontrolled inflammatory response. In this study, we evaluate the association between DARC stiffness progression in HCV-infected patients. We carried out a retrospective cohort study (repeated measures design) 208 noncirrhotic patients chronic hepatitis (CHC) who had at least...
Chronic hepatitis C patients may require steroids due to other comorbidities. However, there is not enough information consider as beneficial or harmful drugs on natural history of chronic C. The aim the present study was examine effect low-dose prolonged therapy with corticosteroids without azathioprine these patients. A retrospective-prospective observational established. Twenty-eight and treated at (≤30 mg/day) for more than 6 months were included. AST, ALT, HCV RNA, liver fibrosis...
The interferon-free regimen paritaprevir/ritonavir, ombitasvir + dasabuvir (PTV/r/OBV/DSV) has shown high efficacy in patients with hepatitis C virus (HCV) genotype 1b infection when administered for 8 or 12 weeks, but data regarding the 8-week treatment are scarce. aim of our study was to assess and safety administration PTV/r/OBV/DSV a real-world cohort. We performed multicentre observational from Spanish Hepa-C database including receiving weeks (October 2016-November 2017). Those...
Background: The myeloid-epithelial-reproductive tyrosine kinase (MERTK) is involved in hepatic steatosis, inflammation and liver fibrosis. Here we evaluated the association between MERTK rs4374383 single nucleotide polymorphism (SNP) fibrosis progression hepatitis C virus (HCV)-infected patients. Methods: We performed a retrospective study (repeated measures design) 208 patients who had stiffness measurement (LSM), which was assessed by transient elastography No patient cirrhosis at baseline...
the characteristics, screening, and survival of hepatocellular carcinoma (HCC) for patients without cirrhosis have not been fully studied.A retrospective cohort study was performed in non-cirrhotic with histological HCC, between January 2004 October 2018. Their treatment, follow-up overall were described.25 332 HCC met inclusion criteria (7.5%), 76% males median age 69.9 years. The main etiology liver disease hepatitis B virus (HBV) (32%), followed by non-alcoholic steatohepatitis (NASH)...