A5061274935- Eosinophilic Esophagitis
- Eosinophilic Disorders and Syndromes
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Innovations in Medical Education
- Food Allergy and Anaphylaxis Research
- Drug-Induced Adverse Reactions
- Pediatric health and respiratory diseases
- Viral gastroenteritis research and epidemiology
- Urticaria and Related Conditions
- Palliative Care and End-of-Life Issues
- Immunodeficiency and Autoimmune Disorders
- Virus-based gene therapy research
- Bacterial Identification and Susceptibility Testing
- Health Sciences Research and Education
- Empathy and Medical Education
- Polyomavirus and related diseases
- Cystic Fibrosis Research Advances
- Heparin-Induced Thrombocytopenia and Thrombosis
- Colorectal and Anal Carcinomas
- Ethics and Legal Issues in Pediatric Healthcare
- Social Media in Health Education
- Problem and Project Based Learning
- Nursing Diagnosis and Documentation
University of Iowa
2002-2024
University of Illinois Chicago
2009-2023
University of Florida
2023
Mayo Clinic in Arizona
2023
Medical University of South Carolina
2023
Florida College
2023
Albert Einstein College of Medicine
2023
The University of Texas Southwestern Medical Center
2023
Illinois College
2023
University of Iowa Hospitals and Clinics
2016-2022
Peanut oral immunotherapy, using a variety of approaches, has been previously shown to induce desensitization in peanut-allergic subjects, but no products have approved for clinical use by regulatory agencies.We performed the first phase 2 multicentered study assess safety and efficacy AR101, novel biologic drug product.A randomized, double-blind, placebo-controlled trial was conducted at 8 US centers. Eligible subjects were 4 26 years old, sensitized peanut, had dose-limiting symptoms ≤143...
We recently identified a genome-wide genetic association of eosinophilic esophagitis (EoE) at 2p23 spanning the calpain 14 (CAPN14) gene, yet causal mechanism has not been elucidated. now show that recombinant CAPN14 cleaves calpain-specific substrate and is inhibited by 4 classical inhibitors: MDL-28170, acetyl-calpastatin, E-64, PD151746. specifically induced (>100-fold) in esophageal epithelium after IL-13 treatment. Epithelial cells overexpressing display impaired epithelial...
Abstract Sepsis, a potentially life-threatening complication of an infection, has the highest burden death and medical expenses in hospitals worldwide. Leukocyte count CD64 expression on neutrophils (nCD64) are known to correlate strongly with improved sensitivity specificity sepsis diagnosis at its onset. A major challenge is lack rapid accurate point-of-care (PoC) device that can perform these measurements from minute blood sample. Here, we report PoC microfluidic biochip enumerate...
Sepsis is a leading cause of death and the most expensive condition to treat in U.S. hospitals. Despite targeted efforts automate earlier detection sepsis, current techniques rely exclusively on using either standard clinical data or novel biomarker measurements. In this study, we apply machine learning assess predictive power combining multiple measurements from single blood sample with electronic medical record (EMR) for identification patients early peak phase sepsis large community...
Glycans, with their variable compositions and highly dynamic conformations, vastly expand the heterogeneity of whatever factor or cell they are attached to. These properties make them crucial contributors to biological function organismal health also very difficult study. That may be changing as we look future glycobiology.
ABSTRACT Eosinophilic esophagitis (EoE) is a progressive inflammatory disease of the esophagus. Untreated or uncontrolled over time can lead to development fibrosis and formation strictures. Once patient develops strictures, it difficult treat with available medical therapies will often require esophageal dilations. The Food Drug Administration recently approved dupilumab for treatment EoE in patients older than 12 years. clinical trials excluded We describe case fibrostenotic stricture who...
Rationale. To determine the general utility of clinical (Asthma Control Test) and physiologic (forced expiratory volume in first second exhalation [FEV1] fractionated exhaled nitric oxide level [FeNO]) parameters for characterizing asthma patients. Methods. Two cross-sectional independent studies simultaneously enrolled 100 patients US 109 Spain ≥ 18 years age with a physician-diagnosis confirmed by 12% improvement FEV1 after bronchodilators or presence airway hyperresponsiveness, central...
Currently, in the United States there is a lack of standardized method to effectively screen school children with undiagnosed or poorly controlled asthma. The purpose this proof-of-concept study was assess use American College Allergy, Asthma, and Immunology's (ACAAI) Asthma Screening Questionnaire identify elementary school-age at risk for asthma (undiagnosed) asthma.Children grades 3-5 from one urban two suburban schools completed ACAAI's 14 question screening questionnaire had their peak...
In well-differentiated human airway epithelia, the coxsackie B and adenovirus types 2 5 receptor (CAR) resides on basolateral membrane. Replacing transmembrane cytoplasmic tail of CAR with a glycosyl-phosphatidylinositol anchor (GPI-CAR) allows apical localization GPI-CAR, where it can bind enhance gene transfer in vitro. To test this hypothesis further to investigate requirements barriers we developed an vivo model that quantitatively assesses erythropoietin (EPO) mouse epithelia. Our data...
Successfully targeting the airway epithelium is essential for gene therapy of some pulmonary diseases. However, resistant to virus-mediated transfer with commonly used vectors. Vectors that interact endogenously expressed receptors on apical surface significantly increase efficiency. other endogenous components involved in host immunity may hinder transfer. We tested effect bronchoalveolar lavage liquid (BAL) from patients cystic fibrosis (CF), BAL subjects without CF (non-CF BAL),...
Primary immunodeficiencies (PIs) are a set of heterogeneous chronic disorders characterized by immune dysfunction. They diagnostically challenging because their clinical heterogeneity, knowledge gaps among primary care physicians, and continuing shortages clinically trained immunologists. As result, patients with undiagnosed PIs at increased risk for recurrent infections, cancers, autoimmune diseases.The aim this research is to develop implement decision support (CDS) tool the identification...