A5101920310- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Corneal surgery and disorders
- Retinopathy of Prematurity Studies
- Intraocular Surgery and Lenses
- Corneal Surgery and Treatments
- Ocular Oncology and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Photoreceptor and optogenetics research
- Ophthalmology and Eye Disorders
- Neonatal and fetal brain pathology
- Traumatic Ocular and Foreign Body Injuries
- Ocular Surface and Contact Lens
- Trace Elements in Health
- Nuclear Structure and Function
- Ocular Infections and Treatments
- Vascular Malformations Diagnosis and Treatment
- Ophthalmology and Visual Impairment Studies
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- Drug-Induced Ocular Toxicity
Université de Montréal
2014-2025
Hôpital Maisonneuve-Rosemont
2010-2025
McGill University
2007-2024
Centre Hospitalier Universitaire Sainte-Justine
2022-2023
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2020-2022
Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal
2020-2022
Massachusetts Eye and Ear Infirmary
2014-2017
W.K. Kellogg Foundation
2017
University of Michigan
2016-2017
Michigan United
2017
An important, unmet clinical need is for cost-effective, reliable, easy-to-use, and portable retinal photography to evaluate preventable causes of vision loss in children. This study presents the feasibility a novel smartphone-based imaging device tailored pediatric fundus.Several modifications children were made our previous device, including child-friendly 3D printed housing animals, attention-grabbing targets, enhanced image stitching, video-recording capabilities. Retinal photographs...
Signaling through MEK-->ERK1/2 and PI3 kinases is implicated in many aspects of cell physiology, including the survival oxidant exposure. Oxidants play a role numerous physiological pathophysiological processes, which rely on transport out nucleus. However, how oxidative stress impacts nuclear trafficking not well defined.
To determine the influence of omega-3 supplementation on vitreous vascular endothelial growth factor A (VEGF-A) levels in patients with exudative age-related macular degeneration (wet AMD) receiving intravitreal anti-VEGF treatment.Prospective, randomized, open-label, single-center, clinical trial, consecutive interventional case series.The study included 3 cohorts wet AMD and a control group epiretinal membrane or hole. Twenty being treated were randomized to daily antioxidants, zinc,...
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) make profound contributions to both physiology pathology. While it is widely believed that direct (PDGF-mediated) activation the primary mode of activating PDGFRs, discovery they can also be activated indirectly begs question relevance indirect PDGFRs. In context a blinding eye disease, PDGFRα results in persistent signaling, which suppresses level p53 thereby promotes viability cells drive pathogenesis. Under same...
Cortisol has been suggested as a risk factor for choroidal thickening, which may lead to retinal changes.To compare thickness measurements using optical coherence tomography (OCT) in patients with endogenous active Cushing's syndrome (CS) and evaluate the occurrence of abnormalities same group patients.Cross-sectional study.Outpatient clinic.Eleven female CS hypercortisolism state determined by presence at least two abnormal from urinary cortisol 24 h, no suppression low dose dexamethasone...
Purpose: To report the effect of superficial keratectomy combined with subconjunctival bevacizumab injection in 2 cases corneal neovascularization (NV). Methods: An interventional case series was undertaken on patients NV: 1 due to sclerokeratitis secondary rheumatoid arthritis and other Terrien marginal degeneration. Both underwent (2.5 mg/0.1 mL). Results: Corneal NV regressed surgical removal showed no signs recurrence after 3 months follow-up. reported dramatic subjective improvement...
Purpose: Previous studies have shown that vitreous stimulates degradation of the tumor suppressor protein p53 and knockdown phosphatidylinositol 5-phosphate 4-kinases (PI5P4Kα -β) abrogates proliferation p53-deficient cells. The purpose this study was to determine whether stimulated expression PI5P4Kα -β suppression would inhibit vitreous-induced cellular responses experimental proliferative vitreoretinopathy (PVR). Methods: encoded by PIP4K2A 2B, respectively, in human ARPE-19 cells were...
Purpose: To investigate whether vascular endothelial growth factor (VEGF)–suppression durations contribute to our understanding of clinical trial outcomes by simulating vitreous molar concentrations (Cvm) intravitreal aflibercept (IVT-AFL) and brolucizumab (IVT-BRO) using pharmacokinetic (PK) modeling. Methods: A PK model simulated Cvm after single-dose IVT-AFL, IVT-BRO, ranibizumab (IVT-RAN), extrapolated intraocular VEGF-suppression thresholds durations. Vitreous multidose regimens used in...