A5082254271- Intracerebral and Subarachnoid Hemorrhage Research
- Spine and Intervertebral Disc Pathology
- Down syndrome and intellectual disability research
- Neurosurgical Procedures and Complications
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetics and Neurodevelopmental Disorders
- Nerve injury and regeneration
- Acute Ischemic Stroke Management
- Immunotherapy and Immune Responses
- NF-κB Signaling Pathways
- CAR-T cell therapy research
- Head and Neck Surgical Oncology
- Spinal Hematomas and Complications
- S100 Proteins and Annexins
- MicroRNA in disease regulation
- Meningioma and schwannoma management
- Cancer Research and Treatments
- Congenital heart defects research
- Brain Metastases and Treatment
- Vascular Malformations Diagnosis and Treatment
- Medicinal Plants and Neuroprotection
Taichung Hospital
2021-2024
Jiangsu Vocational College of Medicine
2023
Universiti Putra Malaysia
2014-2022
Monash University
2022
China Medical University
2010-2021
China Medical University Hospital
2010-2021
Australian National University
2020-2021
Xiamen University Malaysia
2021
China Medical University
2009-2019
Post Graduate Medical Institute
2019
Background. Electrical stimulation of damaged peripheral nerve may aid regeneration. Objective. The purpose this study was to determine whether 1 mA percutaneous electrical at 1, 2, 20, or 200 Hz augments regeneration between the proximal and distal stumps. Methods. A10-mm gap made in rat sciatic by suturing stumps into silicone rubber tubes. A control group received no stimulation. Starting week after transection, applied cathode placed stump anode every other day for 6 weeks. Results....
Objectives: To develop a Modified Intracerebral Hemorrhage (MICH) score to determine optimal cut-offs for conservative treatment vs surgical intervention basal ganglia hemorrhage and predict outcomes. Design: Prospective randomized trial. Setting: A 1,720-bed medical center affiliated with university. Patients: In all, 226 patients who presented at our hospital from 2001–2005. Interventions: Group (n = 113) underwent endoscopic surgery; group B treatment. Score differences on the Glasgow...
The Ts1Cje mouse model of Down syndrome (DS) has partial triplication chromosome 16 (MMU16), which is partially homologous to human 21. These mice develop various neuropathological features identified in DS individuals. We analysed the effect MMU16 segment on global gene expression cerebral cortex, cerebellum and hippocampus at 4 time-points: postnatal day (P)1, P15, P30 P84. Gene profiling a total 317 differentially expressed genes (DEGs), selected from spatiotemporal comparisons, between...
Object The authors evaluated a new minimally invasive spinal surgery technique to correct degenerative lumbar stenosis involving split–spinous process laminotomy and discectomy (also known as the “Marmot operation”). Methods This prospective study randomized 70 patients with undergo either Marmot operation (40 patients), or conventional laminectomy (30 without discectomy. Spinal anteroposteri-or diameter, cross-sectional area, lateral recess distance, stability, postoperative back pain,...
Amyloid polymorphism underlies the prion strain phenomenon where a single protein polypeptide adopts different chain-folding patterns to form self-propagating cross-beta structures. Three strains of yeast [PSI], namely [VH], [VK], and [VL], have been previously characterized are amyloid conformers translation termination factor Sup35. Here we define specific sequences Sup35 that necessary for in vivo propagation each these strains. By sequential substitution residues 5-55 by proline...
Transorbital brain injuries caused by metal bar penetration are uncommon and often cause serious damage without prompt treatment. Artifacts the penetrating on computed tomography (CT) obscure actual along path of penetration, delayed treatment for insult may result. We present 2 cases transorbital injury following a bar. CT scans were initially performed both patients. However, image resolution was poor extent could not be ascertained due to severe artifacts associated with bars. Both...
We report a novel method of culturing microglia in three dimension (3D) using collagen as substrate. By within matrix, we aim to emulate the physical state embedded parenchyma. BV2 cell suspensions were prepared with type I and cast into culture plates. To characterise cultured 3D, cultures evaluated for their viability, morphology response lipopolysaccharide (LPS) activation. Conventional monolayer (grown on uncoated collagen-coated polystyrene) set up concurrently comparison. 3D matrices...
Kefir, a fermented probiotic drink was tested for its potential anti-oxidative, anti-apoptotic, and neuroprotective effects to attenuate cellular oxidative stress on human SH-SY5Y neuroblastoma cells. Here, the antioxidant potentials of six different kefir water samples were analysed by total phenolic content (TPC), flavonoid (TFC), ferric reducing power (FRAP), 2,2′-diphenyl-1-picrylhydrazyl radical (DPPH) assays, whereas anti-apoptotic activity hydrogen peroxide (H2O2) induced cells...
Malignant gliomas, particularly glioblastoma multiforme (GBM) tumors, are very difficult to treat by conventional approaches. Although most of the tumor mass can be removed surgical resection, radiotherapy, and chemotherapy, it eventually recurs. There is growing evidence that cancer stem cells (CSCs) play an important role in recurrence. These radioresistant chemoresistant. The commonly used marker for CSCs CD133. amount CSC component closely correlated with malignancy grading. Isolating,...