Intracerebral hemorrhage (ICH) is associated with high mortality and neurological deficits, concurrent hyperglycemia usually worsens clinical outcomes. Aquaporin-4 (AQP-4) important in cerebral water movement. Our aim was to investigate the role of AQP-4 hyperglycemic ICH.Hyperglycemia induced by intraperitoneal injection streptozotocin (STZ; 60 mg/kg) adult Sprague-Dawley male rats. ICH stereotaxic infusion collagenase/heparin into right striatum. One set rats repeatedly monitored MRI at 1,...

GABAergic signaling in hippocampal pyramidal neurons undergoes a switch from depolarizing to hyperpolarizing during early neuronal development. Whether such transformation of action occurs dentate granule cells (DGCs), located at the first stage trisynaptic circuit, is unclear. Here, we use noninvasive extracellular recording monitor effect synaptically released GABA on DGC population. We find that responses adolescent and adult rat DGCs are still rest. Using morphologically realistic model,...

BACKGROUND Epithelioid angiosarcoma (EA) is an aggressive, malignant endothelial-cell tumor of vascular or lymphatic origin. EA often arises from deep soft tissues such as pleura, breast, bone and gastrointestinal tract. It usually affects patients aged 60-70 years associated with high recurrence metastasis rates surgical resection the primary treatment choice. Overall survivals are generally poor, ranging 6 to 16 months. More than 50% died disease within 2 3 diagnosis. CASE SUMMARY We...

BACKGROUND Vertebral artery injury (VAI) is a rare but serious condition, with an incidence of 0.24%–2% following blunt trauma and 1%–6% after penetrating injuries. Often asymptomatic, VAI carries significant risks, including ischemic strokes severe neurological deficits, symptoms appearing up to 6 months postinjury. OBSERVATIONS A 64-year-old man experienced critical neck from rebar penetration, resulting in hemorrhagic shock. Imaging revealed left C3–4 fracture, vertebral (VA) transection,...

Abstract Background Bertolotti’s syndrome (BS) is characterized by the enlargement of transverse processes in caudal lumbar segments, causing chronic and persistent low back pain or sciatica. The present study aimed to describe our surgical technique for BS treatment review existing literature describing unsatisfactory outcomes. Case presentation We report a patient who complained lower soreness that intermittently radiated his left leg longer than 10 years. Based on an examination symptoms...

Accidents caused by fatigue occur frequently, and numerous scholars have devoted tremendous efforts to investigate methods reduce accidents fatigued driving. Accordingly, the assessment of spirit status driver through eyes blinking frequency measurement physiological signals emerged as effective methods. In this study, a drowsiness detection system is proposed combine LF/HF ratio from heart rate variability (HRV) photoplethysmographic imaging (PPGI) percentage eyelid closure over pupil time...

Intracerebral hemorrhage (ICH) is associated with high mortality and disability, hyperglycemia worsens the clinical neurological outcomes of patients ICH. In this study, we utilized proteomic approaches to investigate role in Hyperglycemia was induced by intraperitoneal injection streptozotocin (STZ) adult Sprague-Dawley male rats; ICH stereotaxic infusion collagenase/heparin into right striatum. It observed that size significantly larger hyperglycemic group (n=6 each group). On first day...

// Cheng-Di Chiu 1, 3, 4, 5 , Nai-Wei Yao 2, Jeng-Hung Guo 4 Chiung-Chyi Shen 6 Hsu-Tung Lee 7 You-Pen Hui-Ru Ji Xianxiu Chen Chun-Chung and Chang 2 1 School of Medicine, China Medical University, Taichung, Taiwan Institute Biomedical Sciences, Academic Sinica, Taipei, 3 Graduate Science, Department Neurosurgery, University Hospital, Stroke Center, Minimally Invasive Skull Base Neurological Institute, Taichung Veterans General Neurosurgical Oncology, Correspondence to: Chiu, email:...

Drunk driving accidents have been rapidly increasing in recent times. Although the statistics show a decreasing trend years, reports of drunk are often seen news. To assess vehicle operators for driving, police still use breath-alcohol testers as primary method. However, certified instrument to measure alcohol consumption is expensive, and mouthpiece used consumable. Moreover, breath detection method involves contact measurement, which may cause hygiene concerns. achieve more convenient...

To determine the feasibility of using a real-time continuous glucose monitoring system (RTGMS) in intensive care units, our study focus on preterm infants with diabetic mothers owing to their high risk blood sugar abnormalities. Thirty babies (M = 15 and F 15; ≤ 36 week gestation age) were studied from within 72 hours delivery. These admitted newborn further categorized into groups based whether or without mellitus. Blood levels monitored by both RTGMS traditional intermittent arterial line...

Inhibitory γ-aminobutyric acid (GABA)-ergic interneurons mediate inhibition in neuronal circuitry and support normal brain function. Consequently, dysregulation of is implicated various disorders. Parvalbumin (PV) somatostatin (SST) interneurons, the two major types GABAergic inhibitory hippocampus, exhibit distinct morpho-physiological properties coordinate information processing memory formation. However, molecular mechanisms underlying specialized PV SST remain unclear. This study aimed...

Abstract Astrocytes function as spatial K + buffers by expressing a rich repertoire of channels. Earlier studies suggest that acid‐sensitive tandem‐pore channels, mainly TWIK‐related (TASK) mediate part the passive astroglial membrane conductance. Here, using combination electrophysiology and pharmacology, we investigated presence TASK‐like conductance in hippocampal astrocytes rat brain slices. Extracellular pH shifts to below 7.4 (or above 7.4) induced prominent inward outward) current...

Although no benefits of extracranial-intracranial (EC-IC) bypass surgery in preventing secondary stroke have been identified previously, the outcomes initial symptomatic ischemic and stenosis and/or occlusion among Asian population patients with or without intervention yet to be discussed. The authors aimed evaluate subsequent risk vascular disease cardiac events a history this intervention.

Lumbar degenerative disc disease (LDDD) is a leading cause of chronic lower back pain; however, lack clear diagnostic criteria and solid LDDD interventional therapies have made predicting the benefits therapeutic strategies challenging. Our goal to develop machine learning (ML)-based radiomic models based on pre-treatment imaging for outcomes lumbar nucleoplasty (LNP), which one LDDD.The input data included general patient characteristics, perioperative medical surgical details,...

Purpose: With advances in medical technology, the average lifespan has increased, leading to a growing significance of idiopathic normal pressure hydrocephalus (iNPH), particularly elderly population.Most patients with iNPH have been treated either ventriculo-peritoneal shunts (VPS) or conservative measures.However, lumbo-peritoneal (LPS) emerged as an alternative treatment option for recent decades, extensive research still lacks comparing outcomes LPS those VPS non-surgical treatment.The...

Percutaneous endoscopic lumbar decompression is gaining attention as a minimally invasive surgery. Here, the authors report rare complication of pneumocephalus caused by vacuum drain after biportal spinal surgery (BESS) for stenosis.A 79-year-old woman with stenosis over L4-5 level received BESS. No visible dural tear was encountered during surgery, and placed Approximately 150 mL cerebrospinal fluid drained on postoperative day 1. Simultaneously, symptoms intracranial hypotension were...

In the biometric field, vein identification is a vital process that constrained by invisibility of veins as well other unique features. Moreover, users generally do not wish to have their personal information uploaded cloud, so edge computing has become popular for sake protecting user privacy. this paper, we propose low-complexity and lightweight convolutional neural network (CNN) design intellectual property (IP) shortening inference time in finger recognition. This system can operate...

A luminescent zone located midway between the corona and starting point of breakdown channel in liquid n-hexane with point-point electrodes has been photographed traced a microdensitometer. The luminescence is spherical shape approximately 200 mu m diameter at 10 mm gap length. region shown to belong part while initiate from zone. After short period irradiation by diffused UV source fluoresces darkness; it invisible when illuminated tungsten filament lamp. Chemical reactions due electrical...

G72 has been characterised as a susceptibility gene that can have wide-ranging effects in number of neurodegenerative diseases, including schizophrenia and major depression. Indeed, its product, pLG72, is potential serum biomarker for schizophrenia. Previous transcriptomic biochemical studies indicated pLG72 may induce the production mitochondrial reactive oxygen species (ROS), resulting cell damage. Here, we investigated mechanism by transfecting human U87 glioblastoma line with construct....