A5019197599- Histone Deacetylase Inhibitors Research
- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Curcumin's Biomedical Applications
- Neuropeptides and Animal Physiology
- Synthesis and biological activity
- Phytochemical Studies and Bioactivities
- Nerve injury and regeneration
- Macrophage Migration Inhibitory Factor
- Natural product bioactivities and synthesis
- Synthesis and Biological Evaluation
- Reproductive System and Pregnancy
- Nuclear Receptors and Signaling
- Pain Mechanisms and Treatments
- Multicomponent Synthesis of Heterocycles
- Synthesis of Tetrazole Derivatives
- Essential Oils and Antimicrobial Activity
- Galectins and Cancer Biology
- Banana Cultivation and Research
- Bioactive Compounds in Plants
- Computational Drug Discovery Methods
- Biochemical and Structural Characterization
- Garlic and Onion Studies
- Reproductive tract infections research
- Immune cells in cancer
Anadolu University
2015-2024
Eskişehir City Hospital
2015-2024
Universidad de Sevilla
2023
Pamukkale University
2021
St Thomas' Hospital
1997
In this study, vitamin A palmitate (VAP)-loaded poly(lactic-co-glycolic acid) (PLGA)/chitosan-coated PLGA nanoparticle (NP) systems were prepared by the nanoprecipitation technique. The characterized parameters such as particle size, polydispersity index (PDI), ζ-potential, encapsulation efficiency, in vitro dissolution, and release kinetic study. Then, cytotoxicity wound healing profiles of designed NP formulations HaCaT (human keratinocyte skin cell lines) determined. size VAP-loaded NPs...
We report the presence in rat spinal cord of a novel neuronal system expressing tyrosine kinase receptor (trkA), high affinity for nerve growth factor (NGF). TrkA immunoreactive cell bodies were observed intermediate grey matter and classified into three main groups: central canal cells located dorsolateral to aqueduct, partition between lamina X, lateral border grey, morphologically heterogeneous group which included large near border. In situ hybridization confirmed that all these areas...
Several natural products have been proven to prevent neurodegenerative disorders by potentiating the action of nerve growth factor (NGF). Among them, secoiridoids recently attracted interest for their potential use as neuritogenic compounds. A source these compounds is root Gentiana lutea L. used in food improve digestion. The aim this work was evaluate activity methanolic extracts cultivated, wild and commercial roots G. using rat pheochromocytoma (PC12) cells. Neuritogenic assessed...
Abstract INTRODUCTION Neuroinflammation is a major contributor to the progression of frontotemporal dementia (FTD). Galectin‐3 (Gal‐3), microglial activation regulator, holds promise as therapeutic target and potential biomarker. Our study aimed investigate Gal‐3 levels in patients with FTD assess its diagnostic potential. METHODS We examined brain, serum, cerebrospinal fluid (CSF) samples controls. Multiple linear regressions between other markers were explored. RESULTS increased...
Ketorolac tromethamine (KT) is a non-steroidal anti-inflammatory drug from the heteroaryl acetic acid derivatives family. The most widely used new nanotechnological approaches for topical delivery are polymeric nanoparticles (NPs).Successful results have been obtained with low doses in many treatments, such as cancer, antimicrobial, pain, made nanoparticle formulations of active ingredients.NPs were prepared using Nano Spray-Dryer. cytotoxicity optimum formulation BJ (ATCC® CRL-2522™) human...
Parkinson’s disease (PD) is a chronic, progressive, and age-related neurodegenerative disorder characterized by the loss of midbrain dopaminergic neurons caused accumulation free radicals oxidative stress. Based on neuroprotective properties 2-pyrazoline derivatives, in current work, 1-(phenyl/4-substituted phenyl)-3-(2-furanyl/thienyl)-5-aryl-2-pyrazolines (3a–i, 4a–i) were synthesized via cyclization chalcones (1, 2) with suitable phenylhydrazine hydrochloride derivatives. All these...
The leading cause of cancer‐related death is lung cancer, with metastasis being the most common death. To elucidate role macrophages in cancer and angiogenesis processes, we established an vitro co‐culture model A549 or HUVEC THP‐1 cells that polarized to M2c hydrocortisone. proteasome inhibitors bortezomib ixazomib were investigated for their effects on proliferation, invasion, migration, metastasis, pathways. gene expression panels, including crucial genes related proteasomes, after...
Recent advancements in cancer therapy have led to the development of novel nanoparticle-based drug delivery systems aimed at enhancing efficacy chemotherapeutic agents. This study focuses on evaluating aprepitant-loaded PLGA and Eudragit RS 100 nanoparticles for their potential antiangiogenic effects. Characterization studies revealed that exhibited particle sizes ranging from 208.50 238.67 nm, with monodisperse distributions (PDI < 0.7) stable zeta potentials (between − 5.0 15.0 mV)....
Neuropathological characteristics of neurodegenerative disorders are atrophy or loss specific neurons in the brain areas.Small-molecule products like epigenetic drugs, which can activate silenced genes, regulate chromatin remodelling and transcription, is presently been focused as an alternative approach for eliciting neuritogenic activity.Trichostatin A (TSA) has effectively investigated cancer treatment but it also shown to possess potential.In this study, was aimed compare effects two...
Chlamydia pneumoniae (Cpn) is a gram-negative intracellular pathogen that causes variety of pulmonary diseases, and there growing evidence it may play role in Alzheimer’s disease (AD) pathogenesis. Cpn can interact functionally with host histones, altering the host’s epigenetic regulatory system by introducing bacterial products into tissue inducing persistent inflammatory response. Because difficult to propagate, isolate, detect, modified LPS-like neuroinflammation model was established...
We investigated the fundamental function of lung cancer tumour microenvironment.Proteasome inhibition has emerged as a clinically successful anti-cancer therapeutic strategy, with antineoplastic medication bortezomib showing high efficacy against multiple cancers.Tumour-associated macrophages (TAMs), which migrate to stroma, are known promote cell proliferation, apoptosis, and metastasis within microenvironment.However, specific interaction macrophages, cells, still unclear.Most in vitro...
Introduction Escin is the predominant active constituent of Aesculus hippocastanum seed extract. In addition, contains flavonols, glycosides (Aesculin, esculin) and triterpenoid saponins (aescin, escin). The antioxidant biological effect escin means ability to protect against free radicals toxins production in lung cells. Also, several vivo studies have shown that low doses are anti-tumour anti-inflammatory different cell lines. this study was investigated potential cytotoxic effects...
We report the presence in rat spinal cord of a novel neuronal system expressing tyrosine kinase receptor (trkA), high affinity for nerve growth factor (NGF). TrkA immunoreactive cell bodies were observed intermediate grey matter and classified into three main groups: central canal cells located dorsolateral to aqueduct, partition between lamina X, lateral border grey, morphologically heterogeneous group which included large near border. In situ hybridization confirmed that all these areas...
Lung cancer is one of the most diagnosed cancers worldwide and development anticancer agents for treatment lung an important task researchers. For this purpose, herein pyrazoline-based compounds 1–18 were investigated their cytotoxic effects on A549 human adenocarcinoma CCD-19Lu fibroblast cell lines using MTT assay. According to results, 1-(4-methoxyphenyl)-3-(2-furanyl)-5-(4-methylphenyl)-2-pyrazoline (7) was identified as promising agent due its selective inhibitory effect line with IC50...
Chlamydia pneumoniae (Cpn) is a gram-negative intracellular pathogen that causes variety of pulmonary diseases, and there growing evidence it may play role in Alzheimer's disease (AD) pathogenesis. Cpn can interact functionally with host histones, altering the host's epigenetic regulatory system by introducing bacterial products into tissue inducing persistent inflammatory response. Because difficult to propagate, isolate, detect, modified LPS-like neuroinflammation model was established...