A5081954638- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Prostate Cancer Treatment and Research
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Advanced Radiotherapy Techniques
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Alzheimer's disease research and treatments
- Estrogen and related hormone effects
- Parkinson's Disease Mechanisms and Treatments
- Bone health and treatments
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Urologic and reproductive health conditions
- Advanced MRI Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Nuclear Physics and Applications
- Breast Cancer Treatment Studies
- Mechanisms of cancer metastasis
Centre hospitalier universitaire de Québec
2011-2025
Université Laval
2016-2025
Centre hospitalier de l'Université Laval
2021
Lenox Hill Hospital
2018
Hofstra University
2018
Hôtel-Dieu de Québec
2016
Peter MacCallum Cancer Centre
2010-2014
Cancer Research Center
2014
The University of Melbourne
2010-2013
Vanderbilt University
2011
Abstract Purpose Accurate dosimetry is critical for ensuring the safety and efficacy of radiopharmaceutical therapies. In current clinical practice, MIRD formalisms are widely employed. However, with rapid advancement deep learning (DL) algorithms, there has been an increasing interest in leveraging calculation speed automation capabilities different tasks. We aimed to develop a hybrid transformer-based model that incorporates multiple voxel S -value (MSV) approach voxel-level [ 177...
Ventilation-perfusion (V/Q) scintigraphy is established for regional assessment of lung function in a variety diseases, including pulmonary embolism (PE). PET/CT may further improve the accuracy and utility V/Q imaging because its superior technical characteristics. This pilot study assessed feasibility performing compared diagnostic with conventional patients clinical suspicion PE.Ten undergoing were prospectively recruited. was performed after inhalation (68)Ga-carbon nanoparticles...
Purpose: To create an accurate map of the distribution radiation dose deposition in healthy and target tissues during radionuclide therapy. Methods: Serial quantitative SPECT/CT images were acquired at 4, 24, 72 h for 28 177 Lu‐octreotate peptide receptor therapy (PRRT) administrations 17 patients with advanced neuroendocrine tumors. Deformable image registration was combined in‐house programming algorithm to interpolate pharmacokinetic uptake clearance a voxel level. The resultant cumulated...
Because of challenges in performing routine personalized dosimetry radiopharmaceutical therapies, interest single-time-point (STP) dosimetry, particularly using only a single SPECT scan, is on the rise. Meanwhile, there are questions about reliability STP with limited independent validations. In present work, we analyzed 2 methods and evaluated dose errors for several radiopharmaceuticals based effective half-life distributions. <b>Methods:</b> We first challenged common assumption that...
Abstract Purpose We present the results of an open-label, phase I/II study evaluating safety and efficacy novel somatostatin receptor (SSTR) antagonist [ 177 Lu]Lu-satoreotide tetraxetan in 40 patients with previously treated, progressive neuroendocrine tumours (NETs), which dosimetry was used to guide maximum administered activity. Methods This conducted two parts. Part A consisted 15 who completed three cycles at a fixed activity peptide amount per cycle (4.5 GBq/300 µg). B, included 25...
Intrapatient intermetastatic heterogeneity (IIH) has been demonstrated in metastatic castration-resistant prostate cancer (mCRPC) patients and is of the utmost importance for radiopharmaceutical therapy (RPT) eligibility. This study was designed to determine prevalence IIH RPT eligibility mCRPC through a triple-tracer PET imaging strategy.
The aim of the present study was to evaluate impact point spread function (PSF) reconstruction on quantitative values and diagnostic accuracy FDG PET/CT for nodal staging in non-small cell lung cancer.Fifty-eight consecutive examinations were reconstructed with both ordered subset expectation maximization (OSEM) PSF algorithms. Two readers independently performed a randomized blinded review gave status (N0, N1, N2, or N3) each PET data set. When discordant, consensus reached third reader....
The aim of the study is to assess accuracy activity quantification 177Lu studies performed according recommendations provided by committee on Medical Internal Radiation Dose (MIRD) pamphlets 23 and 26. performances two scatter correction three segmentation methods were compared. Additionally, tomographic planar for determination camera normalization factor (CNF) was evaluated. Eight phantoms containing inserts different sizes shapes placed in air, water, radioactive background scanned using...
// Nupur K. Purohit 1, 2, 3 , Rashmi G. Shah Samuel Adant 3, 4, 5 Michael Hoepfner 6 Girish M. * and Jean-Mathieu Beauregard 5, 1 Department of Molecular Biology, Medical Biochemistry Pathology, Université Laval, Quebec City, Canada 2 Cancer Research Center, Neurosciences Oncology Branches CHU de Québec, Laval 4 Radiology Nuclear Medicine, Branch Institute Physiology, Charité-Universitätsmedizin Berlin, Germany Senior authorship Correspondence to: Beauregard, email:...
Routine dosimetry is essential for personalized 177Lu-octreotate peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs), but practical and robust methods are needed wide clinical adoption. The aim this study was to assess the accuracy inter-observer reproducibility simplified protocols based on quantitative single-photon emission computed tomography (QSPECT) with a limited number scanning time points. We also updated our injected activity (IA) prescription...
The role of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in prostate cancer (PCa) has not been well defined yet. Because high-grade PCa tends to exhibit increased glycolytic rate, FDG-PET/CT could be useful this setting. aim study was assess the value for pre-operative staging and prognostic stratification patients with at biopsy.Fifty-four a Gleason sum≥8 biopsy underwent as part workup. Thirty-nine radical prostatectomy (RP) pelvic lymph node (LN)...
Camera calibration, which translates reconstructed count map into absolute activity map, is a prerequisite procedure for quantitative SPECT imaging. Both planar and tomographic scans using different phantom geometries have been proposed the determination of camera calibration factor (CF). However, there no consensus on approach best. The aim this study to evaluate all these methods, compare their performance, propose practical accurate method quantitation therapeutic radioisotopes....
To evaluate the dosimetry and pharmacokinetics of novel radiolabelled somatostatin receptor antagonist [
Abstract Introduction: Conventional imaging (CI) is known to have limitations with respect staging of patients primary or relapsed prostate cancer. Positron emission tomography/computed tomography (PET/CT) 18 F‐flurodeoxyglucose (FDG) also often suboptimal because low tracer avidity, but F‐fluorocholine (FCH) appears be a promising alternative molecular probe. We report prospective pilot study PET/CT comparing both tracers for and restaging Methods: Sixteen cancer were evaluated (7 9...
Recent studies have supported a role for amyloid positron emission tomography (PET) imaging in distinguishing Alzheimer's disease (AD) pathology from other pathological protein accumulations leading to dementia. We investigated the clinical utility of PET differential diagnosis at ypical dementia cases and its impact on caregivers. Using tracer 18F-NAV4694, we prospectively scanned 28 patients (mean age 59.3 y, s.d. 5.8; mean MMSE 21.4, 6.0) with an atypical syndrome. Following comprehensive...
SPLASH (NCT04647526) is a multicenter phase III trial evaluating the efficacy and safety of [177Lu]Lu-PNT2002 radioligand therapy in metastatic castration-resistant prostate cancer (mCRPC). This study leveraged lead-in to assess tissue dosimetry evaluate preliminary efficacy, prior expansion into randomized phase. Here we report those results. Enrolled participants had mCRPC that progressed on one androgen receptor pathway inhibitor (ARPI), were prostate-specific membrane antigen (PSMA)...
TPS282 Background: Actinium-225 (Ac-225)-based, prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) represents a promising treatment modality for prostate cancer. First-generation PSMA-targeting ligands (e.g., PSMA-617 and PSMA-I&T) paired with Ac-225 have been associated myelosuppression, renal toxicity, xerostomia (1). LY4181530 (previously PNT2001) pairs PSMA-62, next-generation ligand, which was specifically designed to overcome these limitations. It employs...