A5080849729- Computational Drug Discovery Methods
- Essential Oils and Antimicrobial Activity
- Plant biochemistry and biosynthesis
- Edible Oils Quality and Analysis
- Malaria Research and Control
- Pharmacological Effects of Natural Compounds
- Advanced Chemical Sensor Technologies
- Ginkgo biloba and Cashew Applications
- Phytochemicals and Antioxidant Activities
- Microwave-Assisted Synthesis and Applications
- SARS-CoV-2 and COVID-19 Research
- Analytical Chemistry and Chromatography
- Ethnobotanical and Medicinal Plants Studies
- Ultrasound and Cavitation Phenomena
- Enzyme Catalysis and Immobilization
- Allelopathy and phytotoxic interactions
- Microbial Metabolism and Applications
- Microbial Metabolic Engineering and Bioproduction
- Nuts composition and effects
- Advanced oxidation water treatment
- Algal biology and biofuel production
- Spectroscopy and Chemometric Analyses
- Chemistry and Chemical Engineering
- Phytochemistry and Biological Activities
- Food Chemistry and Fat Analysis
Centre de Recherche sur l'Information Scientifique et Technique
2014-2024
University of Sciences and Technology Houari Boumediene
2003-2017
Centre de Recherche Nucléaire d’Alger
2012
University of Bath
2009
University of Blida
1999
Abstract Extraction experiments with hexane were carried out at atmospheric pressure in Soxhlet, conventional and ultrasound extractions of flaked caraway seeds, detailed results are given for two major plant extract components, carvone limonene. The indicate that yield quality better extraction compared to those by methodology. rates limonene reported ultrasound‐assisted was 1.3–2 times more rapid, depending on temperature, than a system, according the rate constant obtained during initial...
Medicinal herbs have proved along history to be a source of multiple cures. In this paper, we demonstrate how hydroxychloroquine can act as good inhibitor SARS-CoV-2 Spike protein receptor-binding-domain using molecular docking studies. We also unveil interfere in the prevention Lys353 hACE2 from interacting with corresponding binding hotspot present on protein. Further screening artemisinin & derived compounds produced better Vina score than (-7.1 kcal mol-1 for artelinic acid vs. -5.5...
The solubility of artemisinin in a range conventional and novel solvents was evaluated using the COSMO-RS approach, verified experimentally as well against literature data. computational method improved by calibrating limited set experimental data, enhancing accuracy calculations. optimised shown to be reasonable agreement with data; however, lack reliable data is identified an issue. Several perceived green alternatives were targeted offer good artemisinin. Extraction from Artemisia annua...
The proposed approach unveils an efficient solvent selection manner for the extraction of active compounds from medicinal plants based on their high solvency target compound while considering green engineering principles. Rationalization resources is achieved through theoretical screening using Hansen solubility parameters in practice (HSPiP) 26 candidates toward antimalarial drug "artemisinin". Solvent challenged to meet some principles, which four solvents are identified and then confirmed...
Pseudomonas aeruginosa is capable to deploy a collection of virulence factors that are not only essential for host infection and persistence, but also escape from the immune system become more resistant drug therapies. Thus, developing anti-virulence agents may directly counteract with specific or disturb higher regulatory pathways controlling production armories urgently needed. In this regard, study reports Pistacia lentiscus L. fruit cyclohexane extract (PLFE1) thwarts P. by targeting...
<p>The role of hydroxychloroquine to prevent hACE2 from interacting with SARS-CoV-2 Spike protein is unveiled. Artemisinin & derived compounds entangle better than into Lys353 and Lys31 binding hotspots the virus protein, therefore preventing infection occurs. Since these molecules are effective antivirals excellent safety track records, their potential repurposing recommended for clinical trials COVID-19 patients.</p>
Artemisinin, a natural product, has received considerable attention in the last few years as potent antimalarial drug.This study reports presence of Artemisinin three Algerian wild Artemisia species assessed by HPLC method: A. herba-alba (AH), campestris subsp. glutinosa (AC), and judaica subsp sahariensis (AJ).The analysis hexane extracts, showed difference artemisinin content studied with yield 0.64%, 0.34% 0.04% for AC, AH AJ, respectively. Moreover, level obtained was better than those...
A compact apparatus in which a specific position can be irradiated by microwaves (MW) and ultrasound (US) simultaneously has been developed.The MW-US reactor designed for atmospheric pressure digestion dissolution of biological chemical products.The treat range throughputs 0.1 to 10 grams liquid or solid sample.Its application analytical chemistry shown two examples where decreases time were demonstrated: determination copper olive oil refractory mineral material Co 3 O 4 .Simultaneous...
In this study, the essential oil composition of Thymus algeriensis genuinus from Algeria was characterised by gas chromatography with flame ionization detector (GC/FID) and confirmed coupled to mass spectrometry (GC/MS). The combination GC/FID GC/MS has resulted in identification 48 compounds then classified into four classes: monoterpene hydrocarbons, oxygenated monoterpenes, sesquiterpene hydrocarbons sesquiterpenes. obtained hydrodistillation is characterized a rich content phenolic such...