A5091242168- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 diagnosis using AI
- Asthma and respiratory diseases
- Head and Neck Cancer Studies
- Medical Imaging and Pathology Studies
- Lung Cancer Research Studies
- Airway Management and Intubation Techniques
- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Ultrasound in Clinical Applications
- Esophageal Cancer Research and Treatment
- Nutrition and Health in Aging
- Management of metastatic bone disease
- Frailty in Older Adults
University of Vermont
2014-2024
University of Vermont Medical Center
2015-2023
Health Net
2018
The University of Texas MD Anderson Cancer Center
2018
Pulmonary and Critical Care Associates
2018
Danbury Hospital
2016
Massachusetts General Hospital
2012-2013
Harvard University
1944-2013
Beth Israel Deaconess Medical Center
2008
Princeton University
1944
Rationale: Less invasive, nonsurgical approaches are needed to treat severe emphysema.Objectives: To evaluate the effectiveness and safety of Spiration Valve System (SVS) versus optimal medical management.Methods: In this multicenter, open-label, randomized, controlled trial, subjects aged 40 years or older with severe, heterogeneous emphysema were randomized 2:1 SVS management (treatment) alone (control).Measurements Main Results: The primary efficacy outcome was difference in mean FEV1...
Abstract Background: Muscle wasting is a component of the diagnosis cancer cachexia and has been associated with poor prognosis. However, recommended tools to measure sarcopenia are limited by sensitivity or need perform additional scans. We hypothesized that pectoralis muscle area (PMA) measured objectively on chest CT scan may be overall survival (OS) in non–small cell lung (NSCLC). Methods: evaluated 252 cases from prospectively enrolling cohort. Eligible had scans performed prior...
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Abstract A 5-day method for determining the soluble silicon (Si) concentrations in nonliquid fertilizer products was developed using a sodium carbonate (Na2CO3)–ammonium nitrate (NH4NO3) extractant followed by visible spectroscopy with heteropoly blue analysis at 660 nm. The 5-Day Na2CO3-NH4NO3 Soluble Si Extraction Method can be applied to quantify plant-available solid levels ranging from 0.2 8.4% an LOD of 0.06%, and LOQ 0.20%. This extraction fertilizers correlates well plant uptake (r2=...
The mammalian runt-related factor 1 (RUNX1) is a master transcription that regulates lineage specification of hematopoietic stem cells. RUNX1 translocations result in the development myeloid leukemias. Recently, has been implicated as tumor suppressor other cancers. We postulated expression may be associated with lung adenocarcinoma etiology and/or progression. evaluated association mRNA overall survival data from Cancer Genome Atlas (TCGA), publically available database. Compared to high...
Late-onset non-allergic asthma in obesity is characterized by an abnormally compliant, collapsible lung periphery; it not known whether this abnormality exists proximal airways. We sought to compare collapsibility of central airways between lean and obese individuals with without asthma.A cross-sectional study comparing luminal area shape (circularity) the trachea, left mainstem bronchus, right bronchus intermedius inferior lobar at RV TLC CT was conducted.In 11 controls (BMI: 22.4 (21.5,...
Abstract Background In developing countries where both high rates of smoking and endemic tuberculosis (TB) are often present, identification early lung cancer can be significantly confounded by the presence nodules such as those due to latent TB (LTB). It is very challenging distinguish LTB without invasive procedures, which have their own risks morbidity even mortality. Methods Our method uses a customized VGG16-based 15-layer 2-dimensional deep convolutional neural network (DNN)...
Background: Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has an excellent diagnostic yield, there remain cases where the diagnosis is not obtained. We hypothesized that additional sampling with a 19-G EBUS-TBNA may increase yield in subset of tissue was required. Methods: Indications for use following 22-G rapid on-site cytologic examination were: (1) uncertainty cytopathologist (eg, nondiagnostic, probable lymphoma, etc.), (2) non–small cell lung...
Abstract Intratumoral delivery of cisplatin by endobronchial ultrasound-guided transbronchial needle injection (EBUS-TBNI) has recently emerged as a therapy for treating peribronchial lung cancers. It remains unclear, however, where best to inject drug into tumor, and at how many sites, so current strategies remain empirical. Motivated the need put EBUS-TBNI treatment cancer on more objective footing, we developed computational model pharmacodynamics following EBUS-TBNI. The accounts...
We recently developed a computational model of cisplatin pharmacodynamics in an endobronchial lung tumor following ultrasound-guided transbronchial needle injection (EBUS-TBNI). The suggests that it is more efficacious to apportion the dose between injections at different sites rather than giving all single central injection, but was calibrated only on blood data from patient. Accordingly, we applied modified version our original set 32 patients undergoing EBUS-TBNI for non-small cell cancer...
Chronic obstructive pulmonary disease is associated with a worse overall survival in non-small cell lung cancer. Lung emphysema one component of chronic disease. We hypothesized that the tumor region may result larger tumors and poorer survival.We evaluated 304 cases cancer from prospectively enrolled cohort. The was divided into equal volumetric thirds (upper, middle, or lower region). Emphysema defined as percentage low-attenuation areas less than -950 Hounsfield units (%LAA-950) measured...
Real-time endobronchial ultrasound images are crucial for the accurate placement of needle in peribronchial lung tumors and lymph nodes diagnostic sampling. Beyond its role as a tool, ultrasound-guided bronchoscopy can also aid delivery anti-cancer agents intratumorally, enabling diagnosis, staging, treatment to occur within same anesthesia, reducing patient's burden. However, determining drug retention distribution situ remains challenging, albeit pivotal assessing success or failure...
Rationale: Follow-up of emphysema patients treated with endobronchial valves is limited to 3–12 months after treatment in prior reports. To date, no comparative data exist between and controls a longer follow-up. Objective: assess the durability Spiration® Valve System (SVS) severe heterogeneous over 24-month period. Methods: EMPROVE, multicenter, randomized controlled trial, presents rigorous comparison control groups for up 24 months. Lung function, respiratory symptoms, quality-of-life...