Important revisions of the solar model ingredients appear after 35 years intense work which have led to an excellent agreement between models and neutrino detections. We first show that updated CNO composition suppresses anomalous position Sun in known galactic enrichment. The following law: He/H= 0.075 + 44.6 O/H fraction number is now compatible with all indicators. then examine existing discrepancies standard - seismic observations suggest some directions investigation solve them. update...

In the context of future space-based asteroseismic missions, we have studied problem extracting rotation speed and rotation-axis inclination solar-like stars from expected data. We focused on slow rotators (at most twice solar speed), firstly because they constitute difficult case secondly some CoRoT main targets are to rates. Our study likelihood function has shown a correlation between estimates axis i rotational splitting deltanu star. By using parameters, deltanu*=deltanu sin(i), propose...

<h3>Importance</h3> Breast cancer comprises a highly heterogeneous group of diseases. Many breast cancers, particularly the more lethal ones, may not satisfy assumptions about biology and natural history necessary for screening mammography to be effective. <h3>Objectives</h3> To compare tumor characteristics cancers diagnosed within 2 years normal mammogram (interval [IBC]) with those screen-detected (SBC) cancer–specific mortality IBC SBC. <h3>Design, Setting, Participants</h3> In this...

Background. Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of taxane treatment and cannot currently be prevented or adequately treated. Physical therapy often used for neural rehabilitation following injury but has not been evaluated in this patient population. Methods. Single-blind, randomized controlled exploratory study compared standard care to physical home program (4 visits) throughout adjuvant chemotherapy stage I-III patients with breast cancer (n = 48)....

We evaluated the impact of COVID-19 on cancer screening in Manitoba, Canada using an interrupted time series (ITS) design and data from Manitoba's population-based, organized programs April 2020 to August 2021. In June (breast was suspended during May 2020), there a 54% decrease between predicted (i.e., observed produced regression models) expected counterfactual values for period by assuming did not occur) number mammograms (ratio = 0.46, 95% Confidence Interval (CI) 0.28–0.64). By December...

Disruptions to health care during the COVID-19 pandemic may have led missed cancer diagnoses. It is critical evaluate association between and incidence address public patient anxiety, inform recovery efforts, identify strategies reduce system's vulnerability future disruptions.To examine in Manitoba, Canada.A population-based cross-sectional study design was conducted using data from Manitoba Cancer Registry an interrupted time-series analysis. All individuals diagnosed with Canada, January...

To apply interim surveillance definitions of Clostridium difficile infection (CDI) cases to 1 year data from the provincewide system Manitoba, Canada, determine epidemiology CDI incident in a population.CDI were categorized with developed by an ad hoc C. working group. Incident recorded provincial database between July 2005 and June 2006 linked hospitalization nursing home databases analyzed.One thousand six identified over year. Five hundred fifteen (51%) associated began healthcare...

Timely diagnosis and care are major determinants of the outcome in acute promyelocytic leukaemia (APL), a malignancy whose incidence may be increasing. The Canadian Cancer Registry (CCR) health system represent valuable settings to study APL epidemiology. We analysed CCR, which contains data on all Canadians with APL. To provide clinical information lacking we obtained from five referral centres during similar time period. Between 1993 2007, there were 399 Canada. Age-standardized was...

To compare the cumulative incidence of mental disorders among adolescents and young adults (AYAs) diagnosed with cancer general population their unaffected siblings.

Abstract Background Megestrol acetate (MA) is an appetite stimulant with efficacy in promoting weight gain adults cancer‐associated anorexia–cachexia. Studies documenting MA children, however, are limited. We present the first randomized, double‐blind, placebo‐controlled clinical trial of versus placebo children cancer and loss. Methods Subjects &lt;18 years age loss (minimum 5% from highest previous weight; or %ideal body &lt;90%) due to and/or therapy were randomized either (7.5 mg/kg/day)...

Effectiveness of the quadrivalent human papillomavirus (QHPV) vaccine against cervical dysplasia has not been estimated using population-based individual level data. We assessed effectiveness (VE) QHPV data collected routinely in Manitoba.Females ≥ 15 years old who received Manitoba between September 2006 and April 2010 privately (n = 3,541) were matched on age to up three nonvaccinated females 9,594). used Cox regression models estimate hazard ratios for outcomes: atypical squamous cells...

The objectives of this study were to examine whether self-rated health differs among older adults different ethnic backgrounds and explore what factors may account for potential differences. was based on the 1983 1996 waves Aging in Manitoba study. A self-report measure background used categorize participants into four groups: British/Canadian, Northern/Central European, Eastern Other. In both 1996, European had significantly reduced odds rating their as good or excellent relative...

Myeloid-derived suppressor cells (MDSCs) are regulatory cell populations that have the ability to suppress effector T responses and promote development of (Tregs). They a heterogeneous population immature myeloid progenitors include monocytic granulocytic subsets. We postulated given rapid expansion post-transplant, these members innate immune system may be important contributors early environment post-transplant. To evaluate kinetics recovery function MDSCs after allogeneic hematopoietic...

Thyroid cancers represent a conglomerate of diverse histological types with equally variable prognosis. There is no reliable prognostic model to predict the risks relapse and death for different thyroid cancers.The purpose this study was build nomograms individualized cancer within 10 years diagnosis based on patients' factors.Competing risk subhazard models were used develop information individual patients in population-based cohort followed up median period 126 months. Analyses conducted...

Up to 30% of patients with a diagnosis colorectal cancer (CRC) present as an emergency (an intestinal obstruction, perforation, or hospital admission) (OPE). There are limited data about the association organized, population-based screening rate presentations.To examine CRC OPE at and time trends in after start organized using highly sensitive fecal occult blood test.A historical cohort study was conducted among 1861 individuals 52 74 years age from January 1, 2007, December 31, 2015, who...

Prior work by our group suggested that a single one hour post-thyroidectomy parathyroid hormone (1 hr PTH) level could accurately stratify patients into high and low risk groups for the development of hypocalcemia. This study looks to validate safety efficacy protocol based on 1 PTH threshold 12 pg/ml. Retrospective analysis consecutive cohort treated with standardized protocol. One hundred twenty five underwent total or completion thyroidectomy their was drawn 1-hour post operatively. Based...

To compare early (3 and 6 month) later (12 24 functional outcomes of stage III IV (M0) oropharyngeal squamous cancer patients treated in sequential cohorts with 3D conformal (3DCRT) or intensity modulated radiotherapy (IMRT).200 population based 83 117 at a single institution 3DCRT then IMRT respectively were prospectively assessed pre-treatment 3, 6, 12 months post treatment. A standard protocol including performance status (KPS, ECOG), 3 Performance Status scales for Head Neck (PSS-HN),...

Objective: The objective of this study was to evaluate the effectiveness an invitation letter on cervical screening participation among unscreened women 30 69 years age. Methods: A cluster randomized trial design used in which (n=31,452) were by forward sortation area (FSA) their postal code intervention group that sent (n=17,068) or a not (n=14,384). Results: Six months after letters mailed, 1,010 (5.92%) and 441 control (3.06%) had Pap test. After adjusting for variables have previously...

To evaluate whether hormone therapy (HT) after nonserous epithelial ovarian cancer is associated with a decrease in overall and disease-free survival.We conducted retrospective cohort study. The Manitoba Cancer Registry Drug Programs Information Network were searched to find all women known ovarian, fallopian tube, or primary peritoneal between 1995 2010 who had used HT treatment. Women did not receive treatment no follow-up excluded.Three hundred ninety-one patients met the inclusion...

Extended thromboprophylaxis after hospital discharge following cancer surgery has been shown to reduce the incidence of venous thromboembolism (VTE); however, this practice not universally adopted. We conducted a population-based analysis determine proportion patients with symptomatic VTE diagnosed within 90 days initial major abdominopelvic who might have benefited from extended thromboprophylaxis.We used Manitoba Cancer Registry identify underwent between 2004 and 2009. The in whom was...