This review is the result of a survey across bibliography about determination several antibiotics in biological, food and environmental samples by liquid chromatography. Their those usually made clinical monitoring, safety studies. A brief description pharmacological activity provided, to complement relevance topic bioanalytical method. Exposure antimicrobial agents, which can be evaluated analysis biological fluids, comes mainly from their extensive use as veterinary agents industrial...

A rapid multiresidue method to quantify three different classes of plant hormones has been developed. The reduced concentrations these metabolites in real samples with complex matrixes require sensitive techniques for their quantification small amounts tissue. described combines high-performance liquid chromatography electrospray ionization tandem mass spectrometry. Deuterium-labeled standards were added prior sample extraction achieve an accurate abscisic acid, indole-3-acetic and jasmonic...

Abstract A procedure based on liquid chromatography/tandem mass spectrometry (LC/MS/MS) is described for the determination of nicotine and its principal metabolites cotinine, trans ‐3‐hydroxycotinine cotinine‐ N ‐oxide, caffeine arecoline in breast milk, using ‐ethylnorcotinine as internal standard. Liquid/liquid extraction with chloroform/isopropanol (95:5, v/v) was used nicotine, ‐3‐hydroxycotinine, ‐oxide under neutral conditions basic conditions. Chromatography performed a C 8...

ABSTRACT We developed a practical and economic method based on micellar liquid chromatography for the quantification of atomoxetine methylphenidate, two central nervous system stimulants used to treat attention deficit hyperactivity disorder, in solid dosage forms. Samples were solved mobile phase directly injected, after filtration. Both drugs resolved from matrix compounds using carbon‐18 column consisting solution 0.10 mol/L sodium dodecyl sulfate—6% 1‐pentanol, phosphate‐buffered pH 7,...

A novel method was developed to detect harmful colours and dyes, in spices other edible foodstuffs.

Mebendazole is an anthelmintic drug used in cattle production. However, residues may occur produced food and excretions, jeopardizing population health. A method based on micellar liquid chromatography (MLC) was developed to determine mebendazole dairy products (milk, cheese, butter, curd) nitrogenous waste (urine dung) from bovine animals. Sample treatment expedited simple dilution or solid-to-liquid extraction, followed by filtration direct injection of the obtained solution. The analyte...

Paroxetine is a potent selective serotonin reuptake inhibitor used for the treatment of depression and related mood disorders. A micellar liquid chromatographic method was developed determination paroxetine in serum urine. Detection carried out using C18 column mobile phase 0.15 M sodium dodecyl sulfate, 6% 1-pentanol at pH 3 (buffer salt 0.01 NaH2PO4) running under isocratic mode 1.0 mL/min electrochemical detection 0.8 V. The analyte eluted without interferences <15 min. proposed...

Imidacloprid, chlorpyrifos, profenofos and cypermethrin are most commonly applied pesticides on green leafy vegetables. After a survey conducted to know the pesticide management practices in Sagar, India, procedure based hybrid micellar liquid chromatography coupled photodiode array detector has been developed validated monitor imidacloprid, content The method was following guideline of SANTE/11,312/2021 terms of: selectivity, linearity (r2> 0.998), limit quantification (0.09–0.25 mg/Kg,...

Acetaminophen is determined in serum and urine samples by a rapid, sensitive, precise chromatographic method without any pretreatment step C18 column using pure micellar mobile phase of 0.02M sodium dodecyl sulfate at pH 7. eluted less than 5 min with no interference the protein band. The use electrochemical UV detection compared. Linearities (r > 0.999), as well intra- interday precision, are studied validation method. Limits (LOD) also calculated to be 0.56, 0.83, 0.74 ng/mL solution,...

A liquid chromatographic procedure has been developed for the determination of carbaryl, a phenyl- N -methylcarbamate, and its main metabolite 1-naphthol, using C18 column (250’mm’ × ’4.6’mm) with micellar mobile phase fluorescence detection at maximum excitation/emission wavelengths 225/333’nm, respectively. In optimization step, surfactants sodium dodecyl sulphate (SDS), Brij-35 -cetylpyridinium chloride monohydrate, organic solvents propanol, butanol, pentanol were considered. The...

Aromatic amines are extensively used in industry but they classified as a potential environment and health hazard. A new high performance liquid chromatography method has been developed optimized, for the determination of eight banned aromatic amines: benzidine, o-anisidine, o-phenylenediamine, o-nitroaniline, 2-methoxy-5-methylaniline (p-cresidine), o-toluidine, p-toluidine p-chloroaniline. The chromatographic conditions were: C18 column, 0.085 M SDS, 3.2% (v/v) pentanol mobile phase...

Isoniazid is a drug that widely used against tuberculosis. However, it shows high interpatient variability in metabolism kinetics and clinical effect, which complicates the prescription of medication jeopardizes success therapy. Therefore, specific patient, pharmacokinetics must be elucidated to decide proper dosage intake frequency make suitable for therapeutic monitoring. This can performed by quantification urine as this process non-invasive allows effects long-time exposure inferred. The...

A method based on micellar liquid chromatography has been developed to determine rosuvastatin, lovastatin and simvastatin in oral solid dosage forms. Samples were solved mobile phase up the target concentration, filtered directly injected. The three statins resolved 30 min, using an aqueous solution of 0.10 M sodium dodecyl sulfate - 7.0% 1-butanol, buffered at pH 3 with 0.01 phosphate salt as phase, running under isocratic mode 1 mL/min through a C18 column. Detection was 240 nm. effect...

Abstract A micellar liquid chromatographic (MLC) procedure was developed for the clinical monitoring of imipramine and its active metabolite, desipramine. The determination these highly hydrophobic substances carried out after direct injection serum samples using a mobile phase composed 0.15 m SDS–6% (v/v) pentanol buffered at pH 7, pumped 1.5 mL/min into C 18 column (250 × 4.6 mm), electrochemical detection 650 mV. Using this MLC method, calibration linear ( r &gt; 0.995) limits (ng/mL)...

Aim: The macrolide antibiotic rifampicin is prescribed against several infections, like tuberculosis disease. This drug decays to quinone. Results/methodology: biological fluids were diluted in a micellar solution and directly injected. Using C18 column mobile phase of 0.15 M SDS-6% 1-pentanol phosphate-buffered at pH 7, running 1 ml/min, the analytes resolved less than 15 min. detection was by absorbance 337 nm. Method validated guidelines European Medicines Agency. Decomposition quinone...