A5047896630- Chronic Kidney Disease and Diabetes
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Gout, Hyperuricemia, Uric Acid
- Dialysis and Renal Disease Management
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Spondyloarthritis Studies and Treatments
- Pharmacological Effects of Natural Compounds
- Erythropoietin and Anemia Treatment
- Erythrocyte Function and Pathophysiology
- Lung Cancer Treatments and Mutations
- Electrolyte and hormonal disorders
- Gastric Cancer Management and Outcomes
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- PARP inhibition in cancer therapy
- RNA Research and Splicing
- Renal cell carcinoma treatment
- Angiogenesis and VEGF in Cancer
- Diabetes Treatment and Management
- Signaling Pathways in Disease
- Hippo pathway signaling and YAP/TAZ
Soochow University
2020-2025
Changzhou No.2 People's Hospital
2015
Nanjing Medical University
2015
Hunan Institute of Mental Health
2013
Studies have shown that microRNAs (miRNAs) are involved in the malignant progression of human cancer. However, little is known about potential role miRNAs breast carcinogenesis. miR-124 expression cancer tissue was measured by quantitative real-time PCR (qRT-PCR). Target prediction algorithms and luciferase reporter gene assays were used to investigate target miR-124. Breast cells growth regulated overexpression or knockdown At end study, tumor-bearing mice tested confirm function In this we...
Purpose: Serum uric acid (SUA) is primarily produced through the hydrolysis of purines in liver, with its excretion largely handled by kidneys. Urate transporter 1 (URAT1) inhibitors are known to enhance elimination via kidneys, but they also increase risk kidney stone formation. Currently, xanthine oxidase (XO) predominant uric-lowering medications on market. Methods: In this study, we utilized single-cell RNA sequencing, spatial metabolomics, plasma flow cytometry explore effects...
Abstract Serum uric acid is an end‐product of purine metabolism. Uric concentrations in excess the physiological range may lead to diseases such as gout, cardiovascular disease, and kidney injury. The includes a variety cell types with specialized functions fluid electrolyte homeostasis, detoxification, endocrine functions. Two‐thirds excreted through kidney, however, exploration markers new therapeutic targets renal tissue hyperuricemia still lacking. Single‐cell spatial omics techniques...
Diabetic angiopathy, which includes diabetic kidney disease (DKD), cardio-cerebrovascular disease, and retinopathy (DR) among other diseases, is one of the most common complications affecting patients. Among these, DKD, a major cause morbidity mortality, affects about 40% Similarly, DR involves retinal neovascularization neurodegeneration as result chronic hyperglycemia main visual impairment blindness. In addition, inflammation also promotes atherosclerosis diabetes, with...
Clinicians have long been interested in understanding the molecular basis of diabetic kidney disease (DKD)and its potential treatment targets. Its pathophysiology involves protein phosphorylation, one most recognizable post-transcriptional modifications, that can take part many cellular functions and control different metabolic processes. In order to recognize changes DKD kidney, this study applied Tandem liquid chromatography-mass spectrometry (LC-MS/MS) Next-Generation Sequencing, along...
<b><i>Introduction:</i></b> Diabetic nephropathy (DN) is related to type 1 and 2 diabetes. They are the leading cause of end-stage renal disease, but underling specific pathogenesis DN not yet clear. Our study was conducted explore how changed transcriptome profiles in kidney. <b><i>Methods:</i></b> The gene expression profile microdissected glomeruli 41 patients 20 healthy controls were included. sample dataset GSE96804 obtained from GEO...
Diabetic nephropathy (DN) is the common cause of renal diseases such as end-stage disease (ESRD) and chronic kidney (CKD). Various diagnostic applications treatment methods are used for clinical but remain some prognosis issues. To avoid morbidity mortality related to DN, early detection complications well targeted therapeutic strategies essential. Considerable evidence indicates that non-coding RNA plays a vital role in biological processes various diseases, biomarkers targets. And most...
Five electronic databases were searched for eligible records. Outcomes presented and analyzed according to the objective response rate (ORR), progression-free survival (PFS) rate, overall (OS) rate. records involving 2,024 participants included in study. The pooled analysis of OS PFS longer with ramucirumab (RAM) therapy than without RAM (odds ratio <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mfenced open="(" close=")"> <mrow> <mtext>OR</mtext> </mrow> </mfenced> <mo>=</mo>...
Background While lung cancer patient outcomes are well-recognized to vary as a function of sex, there has been insufficient research regarding the relationship between sex and EGFR(Epidermal growth factor receptor) response efficacy. The present study therefore sought identify novel sex-related biomarkers bevacizumab/erlotinib (BE) responses in non-small cell (NSCLC) patients. Methods exon array data Gene Expression Omnibus (GEO) dataset were analyzed order patterns mRNA lncRNA expression...