A5076191679- Multicomponent Synthesis of Heterocycles
- Synthetic Organic Chemistry Methods
- Synthesis and biological activity
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Reactions
- Synthesis of heterocyclic compounds
- Synthesis and Biological Evaluation
- Global trade and economics
- Inorganic and Organometallic Chemistry
- Innovative Microfluidic and Catalytic Techniques Innovation
- Synthesis and Characterization of Heterocyclic Compounds
- Monetary Policy and Economic Impact
- Oxidative Organic Chemistry Reactions
- Economic Growth and Productivity
- Chemistry and Chemical Engineering
- Global Trade and Competitiveness
- Microfluidic and Capillary Electrophoresis Applications
- Synthesis of β-Lactam Compounds
- Advanced NMR Techniques and Applications
- Synthesis and Reactions of Organic Compounds
- Fiscal Policy and Economic Growth
- Market Dynamics and Volatility
- Bioactive Compounds and Antitumor Agents
Biocon (India)
2008-2025
Bristol-Myers Squibb (India)
2020-2025
Indian Institute of Technology Palakkad
2024
Syngene International (India)
2008-2023
Bristol-Myers Squibb (Germany)
2021-2023
Indian Institute of Technology Kanpur
1999-2017
Jawaharlal Nehru University
1982-2015
National University of Singapore
2013
Biocon (Switzerland)
2009-2011
TCG Lifesciences (India)
2003-2004
Aims: The role of thioredoxin reductase (TrxR) in tumorigenesis has made it an attractive anticancer target. A systematic approach for development novel compounds as TrxR inhibitors is currently lacking. Structurally diversified share common electrophilic propensities the sulfhydryl groups, among which include Michael reaction acceptors containing α,β-unsaturated carbonyl moiety. We aimed to identify features structurally acceptor-based that would yield a strong inhibitory character....
2-Methyltetrahydrofuran (MTHF) improved separation efficiency, sample loading, and purification, reducing solvent use by 87% process time 89%. It enhanced loading capacity solubility, offering a sustainable, cost-effective solution.
Abstract Hydrogen peroxide activated by boric acid in the presence of sulfuric has been shown to be an efficient oxidizing system for direct conversion aromatic aldehydes and ketones phenols.
The one pot synthesis of a new fused 1,2,5-triazepine-3,6-diones, 1,2,5-triazepine-3,7-diones heterocyles has been described via Petasis reactions. These heterocycles might be suitable for elaboration into larger peptides at amino termini. scope and limitations this method have examined.
India and the European Union are in negotiation process for a Free Trade Agreement.However, as result of vote on June 23, 2016, United Kingdom decided to exit from Union, i.e., Brexit.Consequently, bilateral trade costs between will increase both newly applicable tariff non-tariff barriers, which have direct impact flows these two trading partners an indirect their income growth partners.The has been is most important partner EU, thus deal would not be beneficial it were still member...
An efficient highly convergent route to hitherto unreported 2,3-substituted and annulated benzo[a]quinolizine-4-thiones 3 has been developed. The methodology involves ring annulation of 3,4-dihydro-6,7-dimethoxy-1-methylisoquinoline 1 with a variety readily accessible acyclic cyclic β-oxodithioesters 2 in the presence triethylamine refluxing benzene. These can be converted corresponding benzo[a]quinolizine-4-ones 5 via dethiomethylative hydrolysis respective benzo[a]quinolizinium salts 4...
The one-pot synthesis of a new substituted 1,2,3,4-tetrahydrocarbazoles has been described via Petasis reactions. These tetrahydrocarbazoles exhibits various medicinal importance and might be suitable for elaboration into larger peptides at carboxy termini. scope limitations this method have examined.
Abstract A photocatalyzed and highly efficient trifluoromethylation of N-arylvinylsulfonamides using commercially available CF3SO2Cl as the trifluoromethyl radical source under blue LEDs is reported. The reaction proceeds through cyclization mild conditions. An investigation substrate scope performed to establish a general, synthetically useful protocol for synthesis novel trifluoromethylated 1,3-dihydrobenzo[c]isothiazole 2,2-dioxides in moderate high yields. This method also successfully...
Unnatural amino acids play an important role in peptide based drug discovery. Herein, we report a class of differentially protected azatryptophan derivatives synthesized from N-tosyl-3-haloazaindoles 1 and Fmoc-protected tert-butyl iodoalanine 2 via Negishi coupling. Through ligand screening, Pd2(dba)3/XPhos was found to be superior catalyst for the coupling with zinc derivative give (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)propanoate 3...
Abstract Serious explosions, 1,2 attributed to the use of ether containing peroxides, have occurred in laboratory practice from time time. It has been claimed that various substances will inhibit formation peroxide and thus make safe. The claim tested case copper, mercury, copper‐zinc sodium amalgam, usefulness storing amber glass also tested. Of inhibitors tried, amalgam was best, storage omber delayed peroxide. None devices completely successful preventing only safe procedure is test for...
Determining the purity of deuterium labelled compounds is important due to increasing use these in mass spectrometry (MS) based quantitative analyses for targeting metabolic flux, reducing toxicity, confirming reaction mechanisms during synthesis, predicting enzyme mechanisms, and enhancing efficacy drugs, proteomics, also as internal standards. In present study, a strategy using liquid chromatography electrospray ionization high resolution (LC-ESI-HR-MS) nuclear magnetic resonance (NMR)...
Dihydropyrazolin-5-one dienolate 2 generated by deprotonation of 2,3-dimethyl-4-formyl-1-phenylpyrazolin-5-one (4-formylantipyrine) is shown to be an efficient anionic pyrazolone α-oxy-o-quinodimethane analog, which undergoes facile cycloaddition with a variety dienophiles give substituted indazolones in good yields after dehydration–dehydrogenation cycloadducts.
ABSTRACT Chirally pure enantiomers of differently protected 7‐azatryptophan derivatives ( R‐3c , S‐3c R‐3i S‐3i R‐3m S‐3m R‐3aa and S‐3aa ) were synthesized, which showed solvent‐dependent optical rotation. The obtained results not only exhibited changes in the values but also variation sign (− or +) with different solvents studied. change rotation value was essentially attributed to electron‐donating property, can be correlated donor number solvents. There are two types hydrogen bonds,...
Purpose – This paper aims to examine the relationship between industrial and service sector outputs at aggregate level for different sub-services in India also tries find out whether is changing over time. Design/methodology/approach studies a panel of 16 major Indian states period 1980-2011. Using an econometric analysis, it proceeds estimate increase inter-linkage output sector. study considers variable coefficient model where elasticity with respect changes The element here considered be...
This paper seeks to find whether the shift in production structure away from agriculture services is only result of change income status or changing economic relations among countries has any important role play here. It tries out factors responsible for huge expansion output recent times (1971–2009) considering three different samples (a) a group developed and developing countries, (b) particular also (c) case India. The finds that along with variables representing technological...