A5086254595- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Parasitic infections in humans and animals
- Research on Leishmaniasis Studies
- Congenital Anomalies and Fetal Surgery
- Helminth infection and control
- Microtubule and mitosis dynamics
- Parasitic Infections and Diagnostics
- Cancer Mechanisms and Therapy
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Bone Metabolism and Diseases
- Liver physiology and pathology
- Genetics, Aging, and Longevity in Model Organisms
- Enzyme function and inhibition
- Computational Drug Discovery Methods
- Invertebrate Immune Response Mechanisms
- Pregnancy and preeclampsia studies
- Cancer Genomics and Diagnostics
- Macrophage Migration Inhibitory Factor
- Hepatocellular Carcinoma Treatment and Prognosis
- Trace Elements in Health
- Neurobiology and Insect Physiology Research
- Tardigrade Biology and Ecology
Center for Infection and Immunity of Lille
2011-2021
Inserm
2011-2021
Oncomedics (France)
2021
Centre National de la Recherche Scientifique
2011-2019
Université de Lille
2018-2019
Institut Pasteur de Lille
2011-2014
Université Lille Nord de France
2014
Institut Pasteur
2011-2014
Background The chemotherapy of schistosomiasis currently depends on the use a single drug, praziquantel. In order to develop novel chemotherapeutic agents we are investigating enzymes involved in epigenetic modification chromatin. Sirtuins NAD+ dependent lysine deacetylases that wide variety cellular processes including histone deacetylation, and have been demonstrated be therapeutic targets various pathologies, cancer. Methodology, Principal Findings determine whether Schistosoma mansoni...
Treatment and control of schistosomiasis relies on the only available drug, praziquantel, search for alternative chemotherapeutic agents is therefore urgent. Egg production required transmission immunopathology females S. mansoni lay 300 eggs daily. A large fraction total mRNA in mature female worm encodes one eggshell protein, Smp14. We report that nuclear receptors SmRXR1 SmNR1 regulate Smp14 transcription through recruitment two histone acetyltransferases (HATs), SmGCN5 SmCBP1. The...
Background Alveolar echinococcosis (AE) is a life-threatening disease caused by larvae of the fox-tapeworm Echinococcus multilocularis. Crucial to AE pathology continuous infiltrative growth parasite's metacestode stage, which driven population somatic stem cells, called germinative cells. Current anti-AE chemotherapy using benzimidazoles ineffective in eliminating cell population, thus leading remission parasite upon therapy discontinuation. Methodology/Principal findings We herein describe...
The Venus kinase receptor (VKR) is a single transmembrane molecule composed of an intracellular tyrosine domain close to that insulin and extracellular Flytrap (VFT) structure similar the ligand binding many class C G protein coupled receptors. This (RTK) was first discovered in platyhelminth parasite Schistosoma mansoni, then large variety invertebrates. A vkr gene found most genomes, except S. mansoni which two genes Smvkr1 Smvkr2 exist. VKRs form unique family RTKs present only...
Background Chemotherapy of schistosomiasis relies on a single drug, Praziquantel (PZQ) and mass-use this compound has led to emergence resistant strains Schistosoma mansoni, therefore pointing out the necessity find alternative drugs. Through their essential functions in development metabolism, receptor tyrosine kinases (RTK) could represent valuable drug targets for novel anti-schistosome chemotherapies. Taking advantage similarity between catalytic domains S. mansoni insulin receptors...
Background Alveolar echinococcosis (AE) is a lethal zoonosis caused by the metacestode larva of tapeworm Echinococcus multilocularis. The infection characterized tumour-like growth within host liver, leading to extensive fibrosis and organ-failure. molecular mechanisms parasite organ tropism towards liver influences cytokines hormones on development are little studied date. Methodology/Principal findings We show that E. multilocularis larval stage expresses three members fibroblast factor...
Cellular protein-tyrosine kinases play key roles in signal transduction processes eukaryotes. SmTK4 was the first Syk kinase identified a parasite and found to be tissue-specifically transcribed gonads of adult Schistosoma mansoni. Functional analyses confirmed its role oogenesis spermatogenesis. As an upstream binding partner, cellular SmTK6 isolated from yeast two-hybrid library. Phylogenetic performed this study suggestions hybrid character SmTK6. Biochemical studies made Xenopus oocytes...
Protein kinases (PKs) are one of the largest protein families in most eukaryotic organisms. These enzymes involved control cell proliferation, differentiation and metabolism a large number anticancer drugs currently used directed against PKs. The structure function PKs well conserved throughout evolution. In schistosome parasites, were shown to be essential functions at every stage parasite life cycle, making these promising anti-parasite drug targets. this study, we tested panel commercial...
In the search for new strategies to fight schistosomiasis, unique reproductive biology of Schistosoma mansoni has come into focus research. The development gonads and ability egg production are fundamental not only continuing life cycle but also pathogenicity. Previous studies schistosome demonstrated an influence pairing on gonad female gene expression profiles in both genders. Due limited access specific tissues, however, most these were done at level whole worms neglecting individual...
Abstract Background Receptor tyrosine kinases (RTK) form a family of transmembrane proteins widely conserved in Metazoa, with key functions cell-to-cell communication and control multiple cellular processes. A new RTK named Venus Kinase (VKR) has been described invertebrates. The VKR receptor possesses Fly Trap (VFT) extracellular module, bilobate structure that binds small ligands to induce kinase activity. was shown be highly expressed the larval stages gonads several invertebrates,...
Polo-like kinases (Plks) are a family of conserved regulators variety events throughout the cell cycle, expanded from one Plk in yeast to five Plks mammals (Plk1-5). Plk1 is best characterized member family, homolog founding Polo Drosophila, and plays major role cycle progression by triggering G2/M transition. Plk4/Sak (for Snk (Serum-inducible kinase) akin unique structurally distinct other members, with essential functions centriole duplication. The genome trematode parasite Schistosoma...
Venus kinase receptors (VKRs) are invertebrate receptor tyrosine kinases (RTKs) formed by an extracellular Fly Trap (VFT) ligand binding domain associated via a transmembrane with intracellular (TK) domain. Schistosoma mansoni VKRs, SmVKR1 and SmVKR2, both implicated in reproductive activities of the parasite. In this work, we show that SH2 domain-containing protein SmShb is partner phosphorylated form SmVKR1. Expression these proteins Xenopus oocytes allowed us to demonstrate interacts...
Abstract Background Alveolar echinococcosis (AE) is a lethal zoonosis caused by the metacestode larva of tapeworm Echinococcus multilocularis . The infection characterized tumour-like growth within host liver, leading to extensive fibrosis and organ-failure. molecular mechanisms parasite organ tropism towards liver influences cytokines hormones on development are little studied date. Methodology/Principal findings We show that E. larval stage expresses three members fibroblast factor (FGF)...
Abstract Background Colorectal cancer is a major public concern, being the second deadliest in world. Whereas survival high for localized forms, metastatic colorectal has showed poor prognosis, with 5-year barely surpassing 11%. Conventional chemotherapies against this disease proved their efficiency and remain essential first-line treatment. However, large number of authorized protocols complexifies treatment decision. In common practice, such decision made on an empirical basis, by...