A5052289778- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Platelet Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Hematological disorders and diagnostics
- Otitis Media and Relapsing Polychondritis
- Vasculitis and related conditions
- Intergenerational and Educational Inequality Studies
- RNA and protein synthesis mechanisms
- Acute Lymphoblastic Leukemia research
- Cancer Genomics and Diagnostics
- Gene expression and cancer classification
- Chronic Myeloid Leukemia Treatments
- Machine Learning in Bioinformatics
- Cognitive Abilities and Testing
University of Groningen
2023-2024
University Medical Center Groningen
2022-2024
Myeloid malignancies, including myelodysplastic syndromes (MDS), polycythemia vera, primary myelofibrosis, and acute myeloid leukemia (AML), have a male predominance.1–4 In addition, patients with malignancies inferior survival compared female patients.1,5–7 Recently, it has been reported that the response to treatment hypomethylating agents in MDS is different for males females, suggesting underlying pathobiology.8 Data from previous clinical cohorts showed molecular characteristics of...
We investigated indirect genetic effects (IGEs), also known as nurture, in education with a novel approach that uses phased data to include parent-offspring pairs the transmitted/nontransmitted study design. This method increases power detect IGEs, enhances generalizability of findings, and allows for by parent-of-origin. validated applied this family-based subsample adolescents adults from Lifelines Cohort Study Netherlands (N = 6147), using latest genome-wide association on educational...
Clonal hematopoiesis (CH) is defined by the presence of somatic mutations that may cause clonal expansion hematopoietic cells. Here, we investigated association between platelet count abnormalities, CH and consequences on overall survival development hematological malignancies. Individuals with thrombocytopenia (n = 631) or thrombocytosis 178) ≥60 years, their age- sex-matched controls, were selected within population-based Lifelines cohort 167,729). Although prevalence was not increased in...
With aging, acquired genetic alterations accumulate in hematopoietic stem or progenitor cells. Positive selection may provide a growth advantage for clones carrying driver mutations, and subsequent clonal expansion is called hematopoiesis.1 Mosaic loss of chromosome Y (mLOY) the most commonly cytogenetic alteration aging male individuals from general population.2,3 mLOY associates with all-cause mortality cardiovascular disease (CVD).3,4 Driver gene mutations (GMs) are observed 10%–60%...
Journal Article Corrected proof Clonal haematopoiesis and UBA1 mutations in individuals with biopsy-proven giant cell arteritis population-based controls Get access Jonas B Salzbrunn, Salzbrunn Department of Hematology, University Groningen, Medical Center The Netherlands https://orcid.org/0000-0002-3983-5385 Search for other works by this author on: Oxford Academic PubMed Google Scholar Isabelle A van Zeventer, Zeventer Aniek O de Graaf, Graaf Laboratory Medicine, Radboud Center, Nijmegen,...
Background: The blood cell production represents a balance between myeloid and lymphoid progeny. During aging an increase in the absolute numbers of HSCs is observed their differentiation potential declines. One hallmarks HSC bias decreased lymphopoiesis. A common denominator development somatic mutations within hematopoietic stem compartment. Clonal outgrowth subpopulation these cells called clonal hematopoiesis (CH) measurable >10% elderly over 60 years age. Aims: We studied high skewing...