A5019997484- Mental Health Research Topics
- Treatment of Major Depression
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health and Psychiatry
- Genetic Associations and Epidemiology
- Schizophrenia research and treatment
- Eating Disorders and Behaviors
- Stress Responses and Cortisol
- Mental Health Treatment and Access
- Health, psychology, and well-being
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Psychotherapy Techniques and Applications
- COVID-19 and Mental Health
- Psychosomatic Disorders and Their Treatments
- Cardiac Health and Mental Health
- Cognitive Abilities and Testing
- Child and Adolescent Psychosocial and Emotional Development
- Digital Mental Health Interventions
- Substance Abuse Treatment and Outcomes
- Psychological Well-being and Life Satisfaction
- Bipolar Disorder and Treatment
- Bioinformatics and Genomic Networks
- Electroconvulsive Therapy Studies
University of Groningen
2016-2025
University Medical Center Groningen
2016-2025
Virginia Commonwealth University
2017
Université Paris Cité
2014
Délégation Paris 5
2014
Université Sainte-Anne
1992
Variation in the course of major depressive disorder (MDD) is not strongly predicted by existing subtype distinctions. A new subtyping approach considered here.Two data mining techniques, ensemble recursive partitioning and Lasso generalized linear models (GLMs), followed k-means cluster analysis are used to search for subtypes based on index episode symptoms predicting subsequent MDD World Mental Health (WMH) surveys. The WMH surveys community 16 countries. Lifetime DSM-IV was reported...
Abstract Loneliness is associated with major depressive disorder (MDD), and likely also generalized anxiety (GAD). It unclear if these associations are moderated by age, sex, or genetic susceptibility for MDD. We included 75,279 individuals from the Lifelines COVID-19 study, a longitudinal study of Dutch population-based cohort. Participants completed up to sixteen digital questionnaires between March 2020 January 2021, yielding total 616,129 observations. was assessed Three-Item Scale, MDD...
The frequent occurrence of comorbidity has brought about an extensive theoretical debate in psychiatry. Why are the rates psychiatric so high and what their implications for ontological epistemological status comorbid diseases? Current explanations focus either on classification choices or causal ties between disorders. Based empirical philosophical arguments, we propose a conventionalist interpretation instead. We argue that approach fits well with research clinical practice resolves two...
The gut microbiome is involved in the bi-directional relationship of – brain axis. As most studies this are small and do not account for use psychotropic drugs (PTDs), we explored relations with several internalizing disorders, while adjusting PTDs other relevant medications, 7,656 Lifelines participants from Northern Netherlands (5,522 controls 491 at least one disorder). Disorders included dysthymia, major depressive disorder (MDD), any (AnyDep: dysthymia or MDD), generalized anxiety (GAD)...
The aim of the present study was to determine whether, in patients with depression who had responded favourably selective serotonin reuptake inhibitor citalopram, there a therapeutic benefit continuation treatment. Three hundred and ninety-one depressive were included an open short-term citalopram treatment period. Only at 8 weeks (total score 12 or less on MADRS scale) randomized 24 week double-blind phase. Seventy-four treated placebo 152 same constant dose which patient first Relapse...
Abstract Background Major depression (MD) occurs about twice as often in women men, but it is unclear whether sex differences subsist after disease onset. This study aims to elucidate potential rates and risk factors for MD recurrence, order improve prediction of course illness understanding its underlying mechanisms. Methods We used prospective data from a general population sample ( n = 653) that experienced recent episode MD. A diverse set recurrence was analyzed using Cox models subject...
Abstract Background Most epidemiological studies show a decrease of internalizing disorders at older ages, but it is unclear how the prevalence exactly changes with age, and whether there are different patterns for symptoms traits, men women. This study investigates impact age sex on point across mood anxiety disorders, symptoms, neuroticism. Methods We used cross-sectional data 146 315 subjects, aged 18–80 years, from Lifelines Cohort Study, Dutch general population sample. Between 2012...
Background In search of empirical classifications depression and anxiety, most subtyping studies focus solely on symptoms do so within a single disorder. This study aimed to identify validate cross-diagnostic subtypes by simultaneously considering disability measures. Method A large cohort adults (Lifelines, n = 73 403) had full assessment 16 mood anxiety disorders, measurement physical, social occupational disability. The best-fitting model was identified comparing different hybrid mixture...
Background. Although variation in the long-term course of major depressive disorder (MDD) is not strongly predicted by existing symptom subtype distinctions, recent research suggests that prediction can be improved using machine learning methods. However, it known whether these distinctions refined added information about co-morbid conditions. The current report presents results on this question. Method. Data came from 8261 respondents with lifetime DSM-IV MDD World Health Organization (WHO)...
We investigated indirect genetic effects (IGEs), also known as nurture, in education with a novel approach that uses phased data to include parent-offspring pairs the transmitted/nontransmitted study design. This method increases power detect IGEs, enhances generalizability of findings, and allows for by parent-of-origin. validated applied this family-based subsample adolescents adults from Lifelines Cohort Study Netherlands (N = 6147), using latest genome-wide association on educational...
Although a number of risk factors are known to predict mortality within the first years after myocardial infarction, little is about interactions between factors, whereas these could contribute accurate differentiation patients with higher and lower for mortality. This study explored effect on all-cause in infarction based individual patient data meta-analysis. Prospective 10,512 hospitalized were derived from 16 observational studies (MINDMAPS). Baseline measures included broad set such as...
High rates of psychiatric comorbidity are subject debate: To what extent do they depend on classification choices such as diagnostic thresholds? This paper investigates the influence different thresholds between major depressive disorder (MDD) and generalized anxiety (GAD).Point prevalence MDD GAD was measured in 74,092 subjects from general population (LifeLines) according to Diagnostic Statistical Manual Mental Disorders (DSM-IV-TR) criteria. Comorbidity were compared for by varying number...
Many people across the world use potentially addictive legal and illegal substances, but evidence suggests that not all leads to heavy dependence, as some substances are used moderately for long periods of time. Here, we empirically examine, stability transitions between three substance states: zero-use, moderate use, use. We investigate two large datasets from US Netherlands on yearly usage change alcohol, nicotine, cannabis. Results, which make available through an extensive interactive...
Abstract Background Major depressive disorder (MDD) is a common mood disorder, with heritability of around 34%. Molecular genetic studies made significant progress and identified markers associated the risk MDD; however, slowed down by substantial heterogeneity as MDD assessed differently across international cohorts. Here, we used standardized online approach to measure in multiple cohorts Netherlands evaluated whether this can be epidemiological association depression. Methods Within...