A5091661843- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Medical Imaging Techniques and Applications
- Cancer Treatment and Pharmacology
- Primary Care and Health Outcomes
- Pituitary Gland Disorders and Treatments
- Multiple Myeloma Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Pharmacological Effects and Toxicity Studies
- Cancer therapeutics and mechanisms
- Chromatin Remodeling and Cancer
- Cancer, Hypoxia, and Metabolism
- Advanced MRI Techniques and Applications
- Multiple and Secondary Primary Cancers
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Chronic Lymphocytic Leukemia Research
- Liver Disease and Transplantation
- Nursing Roles and Practices
- Acute Myeloid Leukemia Research
Southmead Hospital
2024
Dana-Farber Cancer Institute
2021-2024
Boston Children's Hospital
2021-2024
National Cancer Institute
2001-2023
National Institute of Neurological Disorders and Stroke
2001
Diffuse intrinsic pontine glioma (DIPG) is a lethal childhood cancer with median survival of less than 1 year. Panobinostat an oral multihistone deacetylase inhibitor preclinical activity in DIPG models. Study objectives were to determine safety, tolerability, maximum tolerated dose (MTD), toxicity profile, and pharmacokinetics panobinostat children DIPG.
Background: End points for assessing drug activity in brain tumors are determined by measuring the change tumor size magnetic resonance imaging (MRI) relative to a pretreatment or best-response scan. Traditionally, two-dimensional (2D) measurements have been used, but one-dimensional (1D) recently proposed as an alternative. Because software estimate three-dimensional (3D) volume from digitized MRI images is available, we compared all three methods of measurement childhood and clinical...
Craniopharyngioma is a histologically benign tumor of the suprasellar region for which survival excellent but quality life often poor secondary to functional deficits from and treatment. Standard therapy consists maximal safe resection with or without radiation therapy. Few prospective trials have been performed, response assessment has not standardized.The Response Assessment in Pediatric Neuro-Oncology (RAPNO) committee devised consensus guidelines assess craniopharyngioma...
Abstract Background The frequency and significance of IDH mutations in glioma across age groups are incompletely understood. We performed a multi-center retrospective age-stratified comparison patients with IDH-mutant gliomas to identify age-specific differences clinico-genomic features, treatments, outcomes. Methods Clinical, histologic, sequencing data from IDH-mutant, grades 2–4 gliomas, were collected collaborating institutions between 2013 2019. Patients categorized as pediatric...
Diffuse intrinsic pontine gliomas (DIPG) generally occur in young school-age children, although can adolescents and adults. The purpose of this study was to describe clinical, radiological, pathologic, molecular characteristics patients ≥10 years age with DIPG enrolled the International Registry (IDIPGR).Patients at diagnosis IDIPGR imaging confirmed were included. primary outcome overall survival (OS) categorized as long-term survivors (LTS) (≥24 months) or short-term (STS) (<24...
PURPOSE Children with low-grade glioma often require long-term therapy and suffer from treatment morbidity. Although targeted agents are promising, tumor targets encompass normal developmental pathways effects of inhibition unknown. Lenalidomide is an immunomodulatory agent wide-ranging properties. Phase I studies indicated greater tolerability lenalidomide in children compared adults a potential dose-response effect. PATIENTS AND METHODS We performed phase II trial pilocytic astrocytomas...
Abstract BACKGROUND Pediatric high-grade gliomas (pHGGs), including diffuse intrinsic pontine glioma (DIPG), are a leading cause of central nervous system tumor-related morbidity and mortality in children. Neuronal activity promotes growth HGGs; one key mechanism is neuronal activity-regulated shedding neuroligin-3 into the microenvironment, mediated by protease (A Disintegrin Metalloprotease) ADAM10. ADAM10 inhibition slows tumor preclinical pHGG models. Here, we report results clinical...
Abstract BACKGROUND Given that radiation therapy is the only treatment modality demonstrated to result in any clinical benefit for children with DIPG, re-irradiation has been explored as a option progressive DIPG. Several studies suggest feasible, and may lengthen survival However, benefits are unclear no standard of care (dose, fractionation, volume, timing, status) defined. The aims this study evaluate re-radiation practices DIPG/DMG define historical cohort who have received (re-XRT)...
Abstract Introduction The Faster Diagnosis Standard (FDS) has been introduced to ensure that patients have cancer diagnosed or ruled out within a maximum of 28 days from referral, for at least 75% patients. This audit focuses on assessing and improving the time taken diagnosis exclusion suspected bladder upper tract in 2-Week Wait (2WW) Haematuria Clinic. Method quality improvement project involved retrospective analysis data collected 2WW Clinic our centre February 2023 May 2023. We...
Abstract BACKGROUND DIPG is an aggressive brainstem tumor with no effective therapy beyond the temporizing effects of radiation (RT). Preclinical studies demonstrated synergistic activity marizomib (MRZ), irreversible CNS-penetrant, pan-proteosome inhibitor, when administered HDAC panobinostat. In a study adults glioblastoma, MRZ was associated significant CNS adverse events interest (ataxia, balance disorder, dizziness, dysarthria, fall, gait disturbance, hallucination) in majority...
Background: The ganglioside GD2 is a potential circulating tumor biomarker for the childhood cancer, neuroblastoma. Interpreting levels of depends in part on knowledge biomarker’s clinical pharmacology. cancer Methods: We studied plasma and cerebrospinal fluid (CSF) pharmacokinetics C18 lipoform two nonhuman primates with indwelling subcutaneous CSF lateral ventricular reservoir systems. was quantified validated high-performance liquid chromatography (HPLC)/tandem mass spectrometry assay....