A5057740989- Neuroscience and Neural Engineering
- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Advanced Sensor and Energy Harvesting Materials
- Conducting polymers and applications
- Transcranial Magnetic Stimulation Studies
- Nerve Injury and Rehabilitation
- Additive Manufacturing and 3D Printing Technologies
- Advanced Memory and Neural Computing
- Tactile and Sensory Interactions
- Bone Tissue Engineering Materials
- Microfluidic and Capillary Electrophoresis Applications
- Mechanical Circulatory Support Devices
- Spinal Cord Injury Research
- 3D Printing in Biomedical Research
- Advanced materials and composites
- Neurological disorders and treatments
- Surgical Simulation and Training
- Microfluidic and Bio-sensing Technologies
- Advanced Machining and Optimization Techniques
- Prosthetics and Rehabilitation Robotics
- Anatomy and Medical Technology
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cardiovascular Issues in Pregnancy
- Cardiac, Anesthesia and Surgical Outcomes
University of Freiburg
2016-2025
Bernstein Center for Computational Neuroscience Freiburg
2018-2024
Brain (Germany)
2022
Recreated missing leg sensations, connected to the prosthesis sensors, restored functional abilities and promoted its cognitive integration.
Objective Hand amputation is a highly disabling event, which significantly affects quality of life. An effective hand replacement can be achieved if the user, in addition to motor functions, provided with sensations that are naturally perceived while grasping and moving. Intraneural peripheral electrodes have shown promising results toward restoration sense touch. However, long‐term usability clinical relevance intraneural sensory feedback not yet been clearly demonstrated. Methods To this...
Abstract Artificial communication with the brain through peripheral nerve stimulation shows promising results in individuals sensorimotor deficits. However, these efforts lack an intuitive and natural sensory experience. In this study, we design test a biomimetic neurostimulation framework inspired by nature, capable of “writing” physiologically plausible information back into nervous system. Starting from in-silico model mechanoreceptors, develop policies. We then experimentally assess them...
Intrafascicular stimulation evokes precise and functional hand movements in monkeys, suggesting clinical opportunities for people with paralysis.
Bioelectronic medicine is a promising venue for treatment of disabilities using implantable neural interfaces. Peripheral neurostimulation residual nerves recently enabled multiple functional benefits in amputees. Despite the preliminary impact on patients' life, over-time stability implants and related nerve reactions are unclear. To unveil mechanisms inform design better nerve-electrode interfaces, we engaged multifaceted approach, merging responses from patients, their histological data,...
Micro-fabricated neural interfaces based on polyimide (PI) are achieving increasing importance in translational research. The ability to produce well-defined micro-structures with properties that include chemical inertness, mechanical flexibility and low water uptake key advantages for these devices.This paper reports the development of transverse intrafascicular multichannel electrode (TIME) used deliver intraneural sensory feedback an upper-limb amputee combination a sensorized hand...
<title>Abstract</title> The loss of hand function is one the most devastating impairments for individuals with paralysis. While current neurotechnologies can partially restore prehensile control, they fall short enabling independent finger movements — an essential requirement full dexterity. Achieving this level precision demands highly selective activation individual muscles or muscle groups. In first-in-human study, we explored a novel approach in chronic tetraplegia. Our method combined...
Successful Plastic Surgery Residency training is subjected to evolving society pressure of lower hourly work weeks imposed by external committees, labor laws, and increased public awareness patient care quality. Although innovative measures for simulation surgery are appearing, there also the realization that basic anatomy should be re-enforced cadaver dissection utmost importance surgical techniques. In development new technology implantable neurostimulatory electrodes management phantom...
Precise control of bionic limbs relies on robust decoding motor commands from nerves or muscles signals and sensory feedback artificial to the nervous system by interfacing afferent nerve pathways. Implantable devices for bidirectional communication with have been developed in parallel research physiological alterations caused an amputation. In this perspective article, we question whether increasing our effort bridging these technologies a deeper understanding amputation pathophysiology...
Abstract Artificial communication with the brain through peripheral nerve stimulation recently showed promising results in people sensorimotor deficits. However, these efforts fall short delivering close-to-natural rich sensory experience, resulting necessity to propose novel venues for converting information into neural patterns, which would possibly enable intuitive and natural sensations. To this aim, we designed tested a biomimetic neurostimulation framework inspired by nature, able “to...
Abstract Direct stimulation of peripheral nerves with implantable electrodes successfully provided sensory feedback to amputees while using hand prostheses. Longevity the is key success, which we have improved for polyimide-based transverse intrafascicular multichannel electrode (TIME). The TIMEs were implanted in median and ulnar three trans-radial up six months. We present a comprehensive assessment electrical properties thin-film metallization as well material status post explantationem ....
Abstract Direct stimulation of peripheral nerves can successfully provide sensory feedback to amputees while using hand prostheses. Recent clinical studies have addressed this important limitation current prostheses solutions different implantable electrode concepts. Longevity the electrodes is key success. We improved long-term stability polyimide-based transverse intrafascicular multichannel (TIME) that showed promising performance in trials by integration silicon carbide adhesion layers....
Thin-film-based electrodes used to interact with nervous tissue often fail quickly if for electrical stimulation, impairing their translation into long-term clinical applications. We initiated investigations about the mechanical load on thin-film caused by fact of stimulation. Platinum Ø 300μm a polyimide carrier were subjected approximately 50 000 asymmetrical, biphasic stimulation pulses in vitro. The electrode's surface was investigated optically means white-light interferometry....
Peripheral Nerve Stimulation (PNS) is a promising approach in functional restoration following neural impairments. Although it proves to be advantageous the number of implantation sites provided compared with intramuscular or epimysial stimulation and fact that does not require daily placement, as case surface electrodes, further advancement PNS paradigms hampered by limitation spatial selectivity due current spread variations nerve physiology. New electrode designs such Transverse...
Substrates and packages of active implantable medical devices are often fabricated from ceramics, such as alumina. Screen-printed PtAu paste is the state-of-the-art metallization for functional structures. Due to solid-state liquid diffusion Au during thermal exposure, solder times limited. Otherwise, metal structures tend delaminate. Moreover, it was shown that with fails after 37.4 years. We established a thin film on alumina process overcome these disadvantages. used sputtered platinum an...
Reliability and reproducibility of implants their fabrication are highly depending on the assembly packaging procedures. Individual skills like soldering introduce inaccuracies should be avoided as much possible. Screen printing is often utilized for metallization ceramics. Using platinum/gold (Pt/Au) paste liquidus diffusion leads to a low adhesion strength Pt/Au pads after soldering. As an alternative, sputtering thin film surface was investigated. However, this alternative comes with huge...
This paper presents an implantable package aimed at hosting a bidirectional neural interface for prosthetic applications. The has been conceived to minimize the invasivity patient, this reason cylindrical container with outer diameter of 7 mm and length 21 designed. package, realized in alumina (Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ), 32 hermetic feedthroughs located top...
The microflex interconnection (MFI) technique is often used to connect electrically and mechanically thin film ribbons or electrodes with a solid substrate like screen printed ceramics. For stabilization reasons epoxy fix the MFI structure. As tends form cracks when surrounded by water electrolytes we are eager find an which provides sufficient insulation between single channels of structure also in moist surrounding. Therefore designed device investigate insulating properties different...
Many micromachined neural implants with multi-channel thin-film electrodes have been presented over the last decades. A transverse intrafascicular electrode (TIME) was developed for translational research to treat phantom limb pain (PLP). Four TIME systems (latest version) implanted 30 days into arm of an amputee. After finishing successfully clinical trials TEVIE-3H explanted. The material composition contacts used stimulation investigated X-ray photoelectron spectroscopy (XPS). System...