A5022023267- Innovation and Knowledge Management
- COVID-19 and Mental Health
- Innovation Diffusion and Forecasting
- Digital Mental Health Interventions
- Animal Virus Infections Studies
- Big Data and Business Intelligence
- Viral Infections and Immunology Research
- COVID-19 Pandemic Impacts
- Long-Term Effects of COVID-19
- Virus-based gene therapy research
- Team Dynamics and Performance
- Viral gastroenteritis research and epidemiology
- Mental Health Treatment and Access
- interferon and immune responses
- Business Strategy and Innovation
- Acupuncture Treatment Research Studies
- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Mental Health Research Topics
- COVID-19 epidemiological studies
- Environmental Sustainability in Business
- Innovative Approaches in Technology and Social Development
- Psychological Well-being and Life Satisfaction
- Migraine and Headache Studies
- Quantum Dots Synthesis And Properties
Oregon State University
2013-2024
Huazhong Agricultural University
2016-2024
Center of Hubei Cooperative Innovation for Emissions Trading System
2016-2024
Wuhan Institute of Virology
2024
Jinyintan Hospital
2024
Chinese Academy of Sciences
2024
Chengdu University of Traditional Chinese Medicine
2021-2023
Oregon State Hospital
2013-2023
Green Valley High School
2020-2021
University of Karachi
2020-2021
Abstract New product development (NPD) speed is a key component of time‐based strategy, which has become increasingly important for managing innovation in fast‐changing business environment. This meta‐analytic review assesses the generalizability relationships between NPD and 17 its antecedents to provide better understanding salient cross‐situationally consistent factors that affect speed. We grouped into four categories project, process, team, found process team characteristics are more...
Healthcare workers are under such a tremendous amount of pressure during the COVID-19 pandemic that many have become concerned about their jobs and even intend to leave them. It is paramount for healthcare feel satisfied with lives pandemic. This study aims examine predictors job satisfaction, life turnover intention Between 10 30 April 2020, 240 in Bolivia completed cross-sectional online survey, which assessed ongoing The results revealed number office days predicted intention, but...
ABSTRACT Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus. The first outbreak of PDCoV was announced from the United States in 2014, followed by reports Asia. nonstructural protein nsp5 a 3C-like protease coronavirus, and our previous study showed that inhibits type I interferon (IFN) production. In this study, we found significantly inhibited IFN-stimulated response element (ISRE) promoter activity transcription genes (ISGs), suggesting also suppresses IFN...
New product development ( NPD ) speed has become increasingly important for managing innovation in fast‐changing business environments due to continuous reduction the life cycle time and increase competition from technological advancements globalization. While existing literature not produced consistent results regarding relationship between success projects, many scholars practitioners assert that increasing is virtually always success. The purpose of this paper examine implicit assumption...
Porcine epidemic diarrhea virus (PEDV), which re-emerged in China October 2010, has spread rapidly worldwide. Detailed analyses of the complete genomes different PEDV strains are essential to understand relationships among re-emerging and historic Here, we analysed 409 from countries, were classified into five subgroup (i.e., GI-a, GI-b, GII-a, GII-b, GII-c). Phylogenetic study genes revealed that newly discovered GII-c exhibited inconsistent topologies between spike gene other genes....
In emerging markets, technology ventures increasingly rely on new product development ( NPD ) teams to generate creative ideas and mold these innovative into streams of products or services. However, little is known about how behavioral integration (a team process) collective efficacy motivational jointly facilitate inhibit innovation performance in markets—especially C hina, the world's largest emerging‐market setting with collectivist high power distance cultures. Drawing social cognitive...
An autonomous team is an emerging tool for new product development ( NPD ). With its high degree of autonomy, independence, leadership, dedication, and collocation, the has more freedom stronger capabilities to be innovative entrepreneurial. Several anecdotal cases suggest that teams are best when applied highly uncertain, complex, projects. However, there no empirical study test such a notion. Moreover, not panacea, implementing them can costly disruptive their parent organization. When...
Abstract Operations management researchers have frequently suggested that autonomy can motivate teams to actively and flexibly adapt fast‐changing environments, fostering innovation creative problem solving. However, empirical studies not consistently supported the benefits of team autonomy. We articulate behavioral mechanistic effects by integrating operations literatures. Further, we view as a bipolar factor argue both on operational outcomes are non‐linear. Drawing information processing...
Coronaviruses (CoVs) infect humans and multiple other animal species, causing highly prevalent severe diseases. 3C-like proteases (3CLpros) from CoVs (also called main proteases) are essential for viral replication also involved in polyprotein cleavage immune regulation, making them attractive effective targets the development of antiviral drugs. Herein, 3CLpro porcine epidemic diarrhea virus, an enteropathogenic CoV, was used as a model to identify novel crucial residues enzyme activity....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose an enormous threat economic activity and public health worldwide. Previous studies have shown that the nonstructural protein 5 (nsp5, also called 3C-like protease) of alpha- deltacoronaviruses cleaves Q231 NF-κB essential modulator (NEMO), a key kinase in RIG-I-like receptor pathway, inhibit type I interferon (IFN) production. In this study, we found both SARS-CoV-2 nsp5 SARS-CoV cleaved NEMO at multiple sites...
Porcine reproductive and respiratory syndrome virus (PRRSV) is an arterivirus from the Nidovirales order that causes failure disease in pigs poses a constant threat to global pig industry. The PRRSV-encoded nonstructural protein 11 (nsp11) nidovirus-specific endoribonuclease (NendoU) conserved throughout Arteriviridae Coronaviridae families. Previously, our research of others demonstrated PRRSV nsp11 inhibits type I interferon (IFN) production through NendoU activity-dependent mechanisms....
Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus. The nonstructural protein nsp5, also called 3C-like protease, responsible for processing viral polyprotein precursors in coronavirus (CoV) replication. Previous studies have shown that PDCoV nsp5 cleaves the NF-κB essential modulator and signal transducer activator of transcription 2 to disrupt interferon (IFN) production signaling, respectively. Whether IFN-stimulated genes (ISGs), IFN-induced antiviral...
The arterivirus nsp4-encoded 3C-like protease (3CL pro ) plays an important role in virus replication and immune evasion, making it attractive target for antiviral therapeutics. Previous work suggested that PRRSV nsp4 suppresses type I IFN production by cleaving NEMO at a single site. In contrast, the present study demonstrates both EAV cleave multiple sites this strategy is essential disruption of production. Moreover, we reveal also cleaves glutamine 205 (Q205), which not targeted nsp4....
The evidence on the predictors of mental health in COVID-19 pandemic has revealed contradictory findings, which prevent effective screening for assistance. This study aims to identify issues, specifically examining age as a nonlinear predictor. Based survey 474 adults using snowball sampling under during April 1th–10th, 2020, Iran, we found that had curvilinear relationship with nonsomatic pain, depression, and anxiety. Specifically, it predicted anxiety disorders, negatively among younger...