A5086392062- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- interferon and immune responses
- Viral Infections and Vectors
- Adipokines, Inflammation, and Metabolic Diseases
- Nanocomposite Films for Food Packaging
- Adipose Tissue and Metabolism
- Herpesvirus Infections and Treatments
- RNA Research and Splicing
- Viral gastroenteritis research and epidemiology
- Cardiac Ischemia and Reperfusion
- Infection Control and Ventilation
- Anesthesia and Sedative Agents
- Advanced Sensor and Energy Harvesting Materials
- RNA and protein synthesis mechanisms
- Dielectric materials and actuators
- Cardiovascular Disease and Adiposity
- RNA regulation and disease
- COVID-19 impact on air quality
- Mosquito-borne diseases and control
- Anesthesia and Neurotoxicity Research
- Nanoparticles: synthesis and applications
Karolinska Institutet
2021-2024
Tianjin Medical University General Hospital
2024
Center of Hubei Cooperative Innovation for Emissions Trading System
2017-2021
Huazhong Agricultural University
2017-2021
SARS-CoV-2 is responsible for several million deaths to date globally, and both fomite transmission from surfaces as well airborne aerosols may be largely the spread of virus. Here, nanoparticle coatings three antimicrobial materials (Ag, CuO ZnO) are deposited on solid flat porous filter media, their activity against viability compared with a viral plaque assay. These nanocoatings manufactured by aerosol self-assembly during flame synthesis. Nanosilver particles coating exhibit strongest...
Cholesterol 25-hydroxylase (CH25H) has recently been identified as a host restriction factor that exerts antiviral effects by catalyzing the production of 25-hydroxycholesterol (25HC). CH25H can be rapidly induced upon infection with some viruses. Porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus, ranked among most important swine pathogens since it was discovered in late 1980s. In this study, we found PRRSV significantly downregulated expression cells so-far...
Coronaviruses (CoVs) are a huge threat to both humans and animals have evolved elaborate mechanisms antagonize interferons (IFNs). Nucleocapsid (N) protein is the most abundant viral in CoV-infected cells, has been identified as an innate immunity antagonist several CoVs, including mouse hepatitis virus (MHV) severe acute respiratory syndrome (SARS)-CoV. However, underlying molecular mechanism(s) remain unclear. In this study, we found that MHV N inhibited Sendai poly(I:C)-induced IFN-β...
Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus. The nonstructural protein nsp5, also called 3C-like protease, responsible for processing viral polyprotein precursors in coronavirus (CoV) replication. Previous studies have shown that PDCoV nsp5 cleaves the NF-κB essential modulator and signal transducer activator of transcription 2 to disrupt interferon (IFN) production signaling, respectively. Whether IFN-stimulated genes (ISGs), IFN-induced antiviral...
<p dir="ltr">SARS-COV-2 is an enveloped, positive-stranded RNA virus belonging to the ß- coronaviruses. The interplay between viral proteins and host factors critical for propagation immune evasion. Extensive virus-host interactome studies have revealed numerous that modulate SARS-CoV-2 replication, including interaction G3BP N protein.</p><p dir="ltr">G3BP1, a key RNA-binding protein, central assembling SGs in response various stressors, infection. <b>In Paper...
<p dir="ltr">SARS-COV-2 is an enveloped, positive-stranded RNA virus belonging to the ß- coronaviruses. The interplay between viral proteins and host factors critical for propagation immune evasion. Extensive virus-host interactome studies have revealed numerous that modulate SARS-CoV-2 replication, including interaction G3BP N protein.</p><p dir="ltr">G3BP1, a key RNA-binding protein, central assembling SGs in response various stressors, infection. <b>In Paper...
Abstract Patients with COVID-19 frequently manifest adipose atrophy, weight loss and cachexia, which significantly contribute to poor quality of life mortality 1,2 . Browning white tissue activation brown are effective processes for energy expenditure 3–7 ; however, mechanistic functional links between SARS-CoV-2 infection thermogenesis have not been studied. In this study, we provide experimental evidence that augments browning non-shivering (NST), contributes atrophy body loss. mouse...
Lipids play a crucial role in the replication of porcine reproductive and respiratory syndrome virus (PRRSV), that is endemic throughout world. However, little known about effect fatty acids (FAs), type vital lipid, on PRRSV infection. In this study, we found treatment with FA biosynthetic inhibitor significantly inhibited propagation, indicating necessity FAs for optimal PRRSV. Further study revealed 5′-adenosine monophosphate (AMP)-activated protein kinase (AMPK), key antagonizing...
Cellular cholesterol plays an important role in the life cycles of enveloped viruses. Previous studies by our group and other groups have demonstrated that depletion cellular methyl-β-cyclodextrin (MβCD) reduces proliferation porcine reproductive respiratory syndrome virus (PRRSV), a Arterivirus has been devastating swine industry worldwide for over two decades. However, how PRRSV infection regulates synthesis is not fully understood. In this study, we showed upregulated activity protein...
Abstract Herein, we report a waterproof anti‐SARS‐CoV‐2 protective film prepared by spray‐coating of an aqueous colloidal dispersion poly(ionic liquid)/copper (PIL/Cu) composite nanoparticles onto substrate. The PIL was suspension polymerization 3‐dodecyl‐1‐vinylimdiazolium bromide in water at 70°C. copper acetate salt added into the nanoparticle and situ reduced anchoring nanoparticles. Despite being waterborne, bulk is intrinsically insoluble formed coating stable water. surface PIL/copper...
Abstract Ras-GTPase-activating protein SH3-domain-binding proteins (G3BP) are multifunctional RNA-binding proteins, pivotal in the initiation of stress granules (SGs). SARS-CoV-2 nucleocapsid (N) exhibits strong binding affinity for G3BP and inhibition SG formation. However, pro-viral role(s) G3BP-N interaction have remained unclear. Here, we comprehensively examined importance infection both vitro vivo. Using reverse genetics, constructed a viral mutant, RATA, which stronger more persistent...
Abstract Ras-GTPase-activating protein SH3-domain-binding proteins (G3BP) are critical for the formation of stress granules (SGs) through their RNA- and ribosome-binding properties. SARS-CoV-2 nucleocapsid (N) exhibits strong binding affinity G3BP inhibits infection-induced SG soon after infection. To study impact G3BP-N interaction on viral replication pathogenesis in detail, we generated a mutant (RATA) that specifically lacks G3BP-binding motif N protein. RATA triggers stronger more...
This study aims to investigate whether androgen deprivation, simulating conditions of aging or disease-induced low testosterone levels, increases the susceptibility male mice sevoflurane neurotoxicity, and supplementation can reverse toxic effects sevoflurane. In here, young were subjected orchiectomy (ORC) induce deprivation. Various techniques, including western blotting, immunofluorescence, Morris Water Maze, Golgi staining, neuronal signal measurement, used evaluate on long-term (ORC 10...