A5047167769- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Advanced MRI Techniques and Applications
- Treatment of Major Depression
- Fetal and Pediatric Neurological Disorders
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Neural dynamics and brain function
- Mental Health and Psychiatry
- Educational and Psychological Assessments
- Neuroscience, Education and Cognitive Function
- Obsessive-Compulsive Spectrum Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Genetic Syndromes and Imprinting
- Language Development and Disorders
- Adrenal Hormones and Disorders
- Advanced NMR Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Blood disorders and treatments
- Transcranial Magnetic Stimulation Studies
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2020-2024
Ospedale Maggiore
2022
Milano Metropoli Development Agency
2017-2019
University of Verona
2009-2018
Azienda Ospedaliera Universitaria Integrata Verona
2015-2018
Azienda Socio Sanitaria Territoriale Lariana
2018
University of Udine
2010
We here present data on immune gene expression of chemokines, chemokine receptors, cytokines and regulatory T-cell (T-reg) markers in chronic patients suffering from either schizophrenia (SCZ, N=20) or bipolar disorder (BD=20) compared with healthy controls (HCs, N=20). extracted RNA peripheral blood mononuclear cells performed real-time (RT)-PCR to measure mRNA levels T-reg markers. All the analyses were Bonferroni-corrected. The classical monocyte activation (M1) il6, ccl3 significantly...
Several strands of evidence reported a significant overlapping, in terms clinical symptoms, epidemiology and treatment response, between the two major psychotic disorders-Schizophrenia (SCZ) Bipolar Disorder (BD). Nevertheless, shared neurobiological correlates these disorders are far from conclusive. This study aims toward better understanding possible common microstructural brain alterations SCZ BD. Magnetic Resonance Diffusion data 33 patients with BD, 19 35 healthy controls were...
Hippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar disorder, are considered to be involved the pathophysiology of psychosis. The hippocampus consists several subfields but it remains unclear their involvement early stages psychosis.The aim this study was investigate volumetric alterations hippocampal at first-episode psychosis (FEP).Magnetic resonance imaging (MRI) data were collected 134 subjects (58 FEP patients; 76 healthy controls [HC]). A...
Ventricular enlargement is one of the most consistent abnormal structural brain findings in schizophrenia and has been used to infer shrinkage. However, whether ventricular related local overlying cortex and/or adjacent subcortical structures or it volume change globally not assessed. We systematically assessed interrelations volumes with gray white matter 40 Brodmann areas (BAs), thalamus its medial dorsal nucleus pulvinar, internal capsule, caudate putamen. acquired MRI ( patients (n = 64)...
Perlini C, Marini A, Garzitto M, Isola Cerruti S, Marinelli V, Rambaldelli G, Ferro Tomelleri L, Dusi N, Bellani Tansella Fabbro F, Brambilla P. Linguistic production and syntactic comprehension in schizophrenia bipolar disorder. Objective: To explore linguistic abilities Specifically, the aims of this study were to: i) investigate microlinguistic (lexicon, morphology, syntax) macrolinguistic (discourse coherence, pragmatics) dimensions speech ii) evaluate skills both Method: performance 30...
Background Hippocampal shrinkage is commonly reported in schizophrenia, but its role the illness still poorly understood. In particular, it unclear how clinical and psychosocial variables relate to hippocampal volumes. Aims To investigate neuroanatomic differences hippocampus using three-dimensional (3D) computational image analysis. Method We used high-resolution magnetic resonance imaging surface-based modelling map 3D profile of adults with schizophrenia ( n =67) a healthy control group =...
Bipolar disorder (BD) is a psychiatric condition causing shifts in mood, energy and activity levels severely altering the quality of life patients even euthymic phase. Although widely accepted, neurobiological bases phase remain elusive. This study aims at characterizing resting state functional BD order to better understand pathogenesis disease build future models.Fifteen (10 females; mean age 40.2; standard deviation 13.5; range 20-61) 27 healthy controls (HC) (21 37; 10.6; 22-60)...
Several, although not all, of the previous small diffusion-weighted imaging (DWI) studies have shown cortical white-matter disruption in schizophrenia.To investigate microstructure with DWI a large community-based sample people schizophrenia.Sixty-eight schizophrenia and 64 healthy controls underwent session to obtain apparent diffusion coefficient (ADC) water molecules. Regions interest were placed lobes.Compared controls, group had significantly greater ADCs frontal, temporal occipital...
Abstract Imaging studies have tried to identify morphological outcome measures of schizophrenia in the last two decades. In particular, longitudinal reported a correlation between larger ventricles, decreased prefrontal volumes and worse outcome. This would potentially allow isolate subtypes patients with prognosis more evident biological impairments, ultimately helping designing specific rehabilitation interventions.