A5018978445- Sepsis Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Infectious Diseases and Mycology
- Inflammation biomarkers and pathways
- Anesthesia and Neurotoxicity Research
- Immune Response and Inflammation
- Infectious Disease Case Reports and Treatments
- Actinomycetales infections and treatment
- Infectious Aortic and Vascular Conditions
- Bacterial biofilms and quorum sensing
- Pregnancy and preeclampsia studies
- Antibiotic Resistance in Bacteria
- Traumatic Brain Injury and Neurovascular Disturbances
- Biomarkers in Disease Mechanisms
- Reconstructive Surgery and Microvascular Techniques
- Child Nutrition and Feeding Issues
- Birth, Development, and Health
- Blood properties and coagulation
- Nutrition and Health in Aging
- Cardiovascular Disease and Adiposity
- Genomics and Phylogenetic Studies
- Metabolomics and Mass Spectrometry Studies
- Anesthesia and Sedative Agents
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Eicosanoids and Hypertension Pharmacology
First Affiliated Hospital of Zhengzhou University
2009-2024
Catholic University of America
1992
Nocardia genus is an aerobic, gram-positive, and opportunistic pathogen, which mainly affects cell-mediated immunosuppressed patients. Early diagnosis treatment greatly improve prognosis. However, the limitation of golden standard-bacterial culture exists. Here, we report a 61-year-old male with pneumonia, sepsis intermuscular abscesses induced by farcinica . Venous blood reported negative results. Former improper did not his condition. With assistant metagenomic next-generation sequencing,...
This study mainly studied the effect of inhibition nuclear factor-κB (NF-κB) signal by pyrrolidine dithiocarbamate (PDTC) on lipopolysaccharide (LPS)-induced inflammatory response, oxidative stress, and mitochondrial dysfunction in a murine acute lung injury model. The results showed that LPS exposure activated NF-κB its upstream proteins caused inflammation, mice. While PDTC adminstration alleviated LPS-induced generation lymphocytes, IL-1β, TNF-α. Malondialdehyde, common product, was...
Purpose: The continuous rise in carbapenemase-producing Enterobacteriaceae infections is a major public health concern. However, there limited information available on New Delhi metallo-β-lactamase-1 (NDM-1) producing Citrobacter koseri . In this study, we isolated bla NDM-1 -carrying C. from stool sample of an inpatient. Our aim was to investigate the phenotypic and genomic features clinically derived carbapenem-resistant isolate characterize transmission pattern IncFII/IncN plasmid that...
To explore the characteristics of changes in peripheral blood lymphocyte subsets patients with sepsis intensive care unit (ICU) and analyze their predictive value for prognosis.The clinical data admitted to surgical (SICU) First Affiliated Hospital Zhengzhou University from January 2020 December 2021 were analyzed retrospectively. The met diagnostic criteria Sepsis-3 ≥ 18 years old. Peripheral venous samples collected all on next morning after admission SICU routine test subsets. According...
To study the effect of Xuebijing on inflammatory response and prognosis in patients with septic shock.A prospective randomized controlled was conducted. Eighty shock admitted to department critical care medicine First Affiliated Hospital Zhengzhou University from January December 2019 were enrolled. The enrolled divided into group control by number table method, 40 cases each group. Both groups strictly followed guidelines for diagnosis treatment take comprehensive measures against sepsis....
To determine the dynamic change in serum levels of activin A (ACTA) and C-reaction protein (CRP) patients with brain injury, to investigate its significance.A prospective study was conducted. total 57 adult injury occurring within 24 hours admitted intensive care unit (ICU) First Affiliated Hospital Zhengzhou University from August 2012 June 2013 were enrolled. The allocated into three groups according their Glasgow coma scale (GCS) as follows: minor (GCS 13-15, n=17), moderate 9-12, n=18),...
To evaluate the sedation and analgesia power security of sufentanil in intensive care unit (ICU), to compare effect with fentanyl.A multicenter randomized controlled trial was conducted. Critical adult patients ICU from 11 hospitals Henan Province June 2011 January 2012 who needed based were enrolled. These randomly divided into two groups 300 cases each group using envelope method according hospital number time sequence inclusion. Exclusion criteria included duration < 48 hours under...
Background: Undernutrition is the main reason for use of artificial nutrition in patients with severe neurological diseases. However, clinical and immunological outcomes enteral supplemented immunomodulatory nutrients these remain unclear. Methods: In this single-center, randomized controlled study, 57 diseases were randomly divided into following two groups according to type they would receive: immune-enhancing (IE) ( n = 27) non-IE (NIE) 30). The IE NIE received standard nutrition,...
To analyze the influencing factors of prognosis patients with diabetic kidney disease (DKD) in intensive care unit (ICU), and their predictive value.Based on inpatient information more than 50 000 from June 2001 to October 2012 latest version American Intensive Care Medical Information Database (MIMIC-III v1.4), data DKD were screened out, including gender, age, body weight, comorbidities [hypertension, coronary heart disease, chronic obstructive pulmonary (COPD), (CKD)], sequential organ...
To investigate the effects of pyrrolidine dithiocarbamate (PDTC) on oxidative stress and mitochondrial function lung tissue in mice with acute injury (ALI) induced by lipopolysaccharide (LPS).Forty female Balb/c were randomly divided into normal saline (NS) control group, LPS model PDTC PDTC+LPS 10 each group. The ALI was reproduced intraperitoneal injection 15 mg/kg LPS. administered intraperitoneally 50 1 hour before treatment NS group given 0.1 mL only, those only. sacrificed at 24 hours...
To investigate the effect of recombinant human thrombogenin (rhTPO) on sepsis-associated thrombocytopenia.A prospective randomized controlled study was conducted. One hundred patients with thrombocytopenia admitted to department critical care medicine First Affiliated Hospital Zhengzhou University from August 2019 October 2020 were enrolled. The enrolled divided into rhTPO-using group (TPO group) and routine (control by random number table method, 50 cases in each group. Both groups treated...
To evaluate prognostic value of pentraxin3 ( PTX3 ) content combining with extravascular lung water index EVLWI in patients sepsis.A retrospective analysis complete clinical data septic admitted to Department Critical Care Medicine the First Affiliated Hospital Zhengzhou University from February 2013 2014 was conducted. These were divided into two groups, survival group and death group, according outcome on 28th day. Pulse continuous cardiac output PiCCO used record levels 1st, 2nd 3rd day...
To explore the relevant clinical test indicators that affect prognosis of patients with acute fatty liver pregnancy (AFLP), and to provide a basis for early diagnosis correct selection treatment methods.A retrospective analysis was conducted. Clinical data AFLP in intensive care unit (ICU) First Affiliated Hospital Zhengzhou University from January 2010 May 2021 were collected. According 28-day prognosis, divided into death group survival group. The data, laboratory examination indicators,...
To observe the expression level of cytokines in patients with sepsis and its effect on prognosis.The clinical data admitted to intensive care unit (ICU) First Affiliated Hospital Zhengzhou University from January 2020 December 2022 were analyzed retrospectively, including gender, age, acute physiology chronic health evaluation II (APACHE II), blood routine, procalcitonin (PCT), C-reactive protein (CRP), levels [interleukins (IL-2, IL-4, IL-6, IL-10, IL-17), tumor necrosis factor-α (TNF-α),...
Objective To study the relationship between disseminated intravascular coagulation (DIC) score and assessment of illness prognosis in sepsis. Methods A retrospective analysis 315 patients with sepsis that admitted into First Affiliated Hospital Zhengzhou University hospital intensive care unit (ICU) from January 2005 to December 2008 was made. The were divided survival group (194 cases) death (112 according outcome within 28 days. difference platelet (PLT) count, fibrinogen (Fib),...
To compare the impact of mean lactate concentration and variability on postoperative outcome after cardiac surgery non-cardiac in critical patients, to explore prognostic value first highest during 24 hours intensive care unit (ICU).A retrospective study was conducted. The patients who were transferred ICU immediately, at least 18 years old whose lengths stay 1 day, admitted First Affiliated Hospital Zhengzhou University from September 2014 2016 enrolled. According concentration, divided...