A5004328014- RNA Interference and Gene Delivery
- Atrial Fibrillation Management and Outcomes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac Arrhythmias and Treatments
- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- Geological formations and processes
- Geological and Geochemical Analysis
- Cardiomyopathy and Myosin Studies
- Geography and Environmental Studies
- Cardiac Imaging and Diagnostics
- Muscle and Compartmental Disorders
- Nanoparticle-Based Drug Delivery
- Pediatric Hepatobiliary Diseases and Treatments
- ECG Monitoring and Analysis
- Dermatology and Skin Diseases
- Williams Syndrome Research
- Case Reports on Hematomas
- Fish biology, ecology, and behavior
- Cardiac Structural Anomalies and Repair
- Infant Nutrition and Health
- Vitamin C and Antioxidants Research
- Cardiac electrophysiology and arrhythmias
- Immunodeficiency and Autoimmune Disorders
- Viral Infections and Immunology Research
Kochi Medical School Hospital
2017-2024
Kōchi University
2017-2024
Fundação de Amparo à Pesquisa do Espírito Santo
2023
Tokyo University of Pharmacy and Life Sciences
2016-2022
Universidade Federal do Rio Grande do Sul
2006
Novartis (Switzerland)
1999
Nanocarriers such as liposomes have been attracting attention novel therapeutic methods for inflammatory autoimmune diseases rheumatoid arthritis and ulcerative colitis. The physicochemical properties of intravenously administered nanomedicines enable them to target inflamed tissues passively. However, few studies attempted determine the influences nanoparticle surface characteristics on inflammation site accumulation. Here, we aimed study effects polyethylene glycol (PEG) modification...
High-sensitivity cardiac troponin T (hs-cTnT) was proposed as a simple and useful diagnostic tool for amyloidosis (CA). We performed exploratory systemic screening using hs-cTnT to detect wild-type transthyretin CA (ATTRwt-CA) in outpatient community-based settings.
In patients with apical hypertrophic cardiomyopathy (HCM), electrocardiography (ECG) often shows left ventricular hypertrophy (LVH) and a negative T wave. A wave disappears over time due to degeneration of the myocardium. However, there are limited reports on temporary change in HCM.We report three HCM LVH inversion their previous ECG who showed decrease depth All them had significant stenosis coronary arteries including anterior descending artery (LAD). After revascularization for LAD...
Abstract Background There is insufficient information regarding the bleeding sites and surgical strategies of cardiac tamponade during catheter ablation for atrial fibrillation (AF). Case presentation Of five patients with tamponade, three required intervention two pericardiocentesis. In first case tamponades requiring intervention, considering that peripheral route was used, catecholamines did not reach heart, due to unstable vital signs, venoarterial extracorporeal membrane oxygenation...
Abstract Background Current guidelines recommend that pulmonary vein (PV) velocity should be recorded by using the right upper (RUPV) during transthoracic echocardiography (TTE) evaluation of left ventricular diastolic function. However, it is uncertain whether PV displayed TTE truly measuring PV. This study aimed to identify actual site each usually detected TTE. Methods We retrospectively studied 105 patients who underwent cardiac computed tomography (CT) and TTE, reconstructed images...
223 A potent immunosuppression was observed in skin-grafted rats1 by concomitant treatment with cyclosporine (CsA) and FTY 720 (FTY), due to a synergy between T-cell activation suppression (by CsA) lymphocyte (LC) homing FTY). The present study developed model which quantitatively describes the action, aiming ultimately at an optimal dose selection. cell-trafficking model, consisting of blood, spleen, thoracic duct lymph (TDL) nodes (LN) [scheme below], fitted measured LC levels2 respective...
In the treatment of inflammatory bowel diseases such as ulcerative colitis (UC), siRNAs are expected to enable fundamental suppression expression pathogenic genes. Oral administration is considered most desirable route drug-administration it can act directly on affected area and improve patient's quality life. However, when orally administered, naked siRNA easily degraded in gastrointestinal tract; therefore, necessary use a carrier protect from degradation. We have previously shown that...