A5090650053- Hormonal Regulation and Hypertension
- Thyroid Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Health disparities and outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Thyroid Cancer Diagnosis and Treatment
- Diabetes Treatment and Management
- Pharmaceutical Economics and Policy
- Advanced Causal Inference Techniques
- Air Quality and Health Impacts
- Metabolism, Diabetes, and Cancer
- Cardiovascular Health and Risk Factors
- Per- and polyfluoroalkyl substances research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pharmaceutical industry and healthcare
- Adrenal Hormones and Disorders
- Chronic Kidney Disease and Diabetes
- Lung Cancer Diagnosis and Treatment
- Diabetes Management and Research
- Blood Pressure and Hypertension Studies
- Chronic Disease Management Strategies
- Obesity, Physical Activity, Diet
- Cardiac Health and Mental Health
- Pituitary Gland Disorders and Treatments
- Dialysis and Renal Disease Management
Kyoto University
2000-2025
Beth Israel Deaconess Medical Center
2025
Deaconess Hospital
2025
Stanford University
2024
Kyoto University of Advanced Science
2024
Harvard University
2024
The University of Tokyo
2018-2023
Kanazawa University
2023
Sumitomo Besshi Hospital
2022-2023
Ito Hospital
2021-2023
<h3>Importance</h3> Subclinical hypothyroidism is a common clinical entity among US adults associated in some studies with an increase the risk of cardiovascular disease (CVD) and mortality. However, extent to which CVD mediates association between elevated serum thyrotropin (TSH) mortality has not yet been well established or sufficiently quantified. <h3>Objective</h3> To elucidate subclinical hypothyroidism, TSH normal free thyroxine, high-normal concentrations (ie, upper normative–range...
Importance Previous studies have shown that individuals who regularly walk, particularly 8000 daily steps or more, experience lower mortality. However, little is known about the health benefits of walking intensively only a few days week. Objective To evaluate dose-response association between number an individual takes more and mortality among US adults. Design, Setting, Participants This cohort study evaluated representative sample participants aged 20 years older in National Health...
Autophagy is a cellular recycling process induced in response to many types of stress. However, little known the signaling pathways that regulate autophagy during acute kidney injury (AKI). Bcl-2/adenovirus E1B 19 kDa-interacting protein (BNIP)3 and sestrin-2 are target proteins hypoxia-inducible factor (HIF)-1α p53, respectively. The aim this study was investigate roles BNIP3 oxidative stress-induced AKI. We used rat ischemia-reperfusion cultured renal tubular (NRK-52E) cells as vivo vitro...
Perfluoroalkyl substances (PFASs) are widespread industrial pollutants that extremely persistent in the environment. A previous study Danish National Birth Cohort (DNBC) found prenatal perfluorooctanoate (PFOA) exposure was associated with decreased birth weight, but had insufficient statistical power to evaluate adverse outcomes. Here, we conducted additional analyses three samples originating from DNBC for 3535 mothers and infant pairs associations between PFASs exposures low weight...
A growing number of independent studies have validated spread through air spaces (STAS) to be a predictor worse prognosis in lung adenocarcinoma. To investigate the prognostic significance STAS according types surgery and locations recurrence, association between anti-anaplastic lymphoma kinase (ALK) expression, we analyzed series 735 Japanese patients with resected adenocarcinoma, which was restaged 8th edition TNM staging system. defined as tumor cells within parenchyma beyond edge main...
Abstract Background In medicine, clinicians treat individuals under an implicit assumption that high-risk patients would benefit most from the treatment (‘high-risk approach’). However, treating with highest estimated using a novel machine-learning method (‘high-benefit approach’) may improve population health outcomes. Methods This study included 10 672 participants who were randomized to systolic blood pressure (SBP) target of either &lt;120 mmHg (intensive treatment) or &lt;140...
Abstract Identifying unequivocal signs of life on Mars is one the most important objectives for sending missions to red planet. Here we report Red Stone, a 163-100 My alluvial fan–fan delta that formed under arid conditions in Atacama Desert, rich hematite and mudstones containing clays such as vermiculite smectites, therefore geologically analogous Mars. We show Stone samples display an number microorganisms with unusual high rate phylogenetic indeterminacy, what refer “dark microbiome”,...
Importance Although cardiovascular disease (CVD) is a known risk factor for depression, evidence lacking regarding whether and to what extent spouse’s CVD associated with the subsequent mental health of individuals. Objective To examine association between onset in spouses depression. Design, Setting, Participants This cohort study examined 277 142 matched married couples enrolled Japan Health Insurance Association insurance program April 2015 March 2022, covering approximately 40%...
Objective To investigate the association between physician characteristics and value of industry payments. Design Observational study. Setting participants Using 2015–2017 Open Payments reports payments linked to Physician Compare database, we examined (physician sex, years in practice, medical school attended specialty) payment value, adjusting for other characteristic institution fixed effects (effectively comparing physicians practicing at same institution). Main outcome measures Our...
Background Heat shock protein beta-1 (HSPB1, also known as HSP27) is a small heat involved in many cellular processes and reportedly protects cells against oxidative stress. Autophagy from types of stress thought to play key role preventing acute kidney injury (AKI). However, little about the HSPB1 autophagy apoptosis pathogenesis AKI. Methods We used rat ischemia/reperfusion AKI model cultured renal tubular an vitro model. To elucidate regulation HSPB1, we evaluated promoter activity...
Aldosterone is a steroid hormone regulating fluid and electrolyte homeostasis known to increase the risk of atherosclerosis. In this study, we examined associations serum aldosterone concentrations with subclinical atherosclerosis all-cause mortality. This study included 948 adults aged 46 88 years from MESA (Multi-Ethnic Study Atherosclerosis) measurements plasma renin activity not taking antihypertensive medications. Coronary calcification was longitudinally assessed using Agatston...
The potential etiological role of early acetaminophen exposure on Autism Spectrum Conditions (ASC) and Attention-Deficit/Hyperactivity Disorder (ADHD) is inconclusive. We aimed to study this association in a collaborative six European population-based birth/child cohorts. A total 73,881 mother-child pairs were included the study. Prenatal postnatal (up 18 months) was assessed through maternal questionnaires or interviews. ASC ADHD symptoms at 4-12 years age using validated instruments....
Social participation has been suggested as a means to prevent depressive symptoms. However, it remains unclear whether one-time boost suffices or needs be sustained over time for long-term prevention. We estimated the impacts of alternative hypothetical interventions in social on subsequent symptoms among older adults.Data were from nationwide prospective cohort study Japanese adults ≥65 years age (n = 32,748). analyzed (1) baseline exposure 2010 (approximating intervention) and (2)...