A5031358151- Transplantation: Methods and Outcomes
- Frailty in Older Adults
- Nutrition and Health in Aging
- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Medical Imaging and Pathology Studies
- Infective Endocarditis Diagnosis and Management
- Cardiac Health and Mental Health
- Cardiac Valve Diseases and Treatments
- Stress Responses and Cortisol
- Intensive Care Unit Cognitive Disorders
- Memory and Neural Mechanisms
- Hormonal Regulation and Hypertension
- Cardiac Structural Anomalies and Repair
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Tracheal and airway disorders
- Organ Transplantation Techniques and Outcomes
- Aortic Disease and Treatment Approaches
- Optimism, Hope, and Well-being
- Genetics and Neurodevelopmental Disorders
- Atherosclerosis and Cardiovascular Diseases
- Cancer survivorship and care
- Marine and coastal plant biology
University of California, Los Angeles
2018-2023
UCLA Health
2021
UCLA Medical Center
2021
VA Greater Los Angeles Healthcare System
2021
Oklahoma State University Center for Health Sciences
2018
Cedars-Sinai Medical Center
2017
Mount Sinai Hospital
2016
Icahn School of Medicine at Mount Sinai
2009-2015
Mount Sinai Hospital
2015
Mount Sinai Medical Center
2015
Stressful life events have been implicated clinically in the pathogenesis of mental illness, but neural substrates that may account for this observation remain poorly understood. Attentional impairments symptomatic these psychiatric conditions are associated with structural and functional abnormalities a network prefrontal cortical structures. Here, we examine whether chronic stress-induced dendritic alterations medial cortex (mPFC) orbital frontal (OFC) underlie behaviors they subserve....
Background/Objectives Frailty, characterized by low physiological reserves, is strongly associated with vulnerability to adverse outcomes. Features of frailty overlap those advanced heart failure, making a distinction between them difficult. We sought determine whether implantation left ventricular assist device ( LVAD ) would decrease frailty. Design Prospective, cohort study. Setting Five academic medical centers. Participants Frail individuals (N = 29; mean age 70.6 ± 5.5, 72.4% male)....
Aldosterone is a steroid hormone regulating fluid and electrolyte homeostasis known to increase the risk of atherosclerosis. In this study, we examined associations serum aldosterone concentrations with subclinical atherosclerosis all-cause mortality. This study included 948 adults aged 46 88 years from MESA (Multi-Ethnic Study Atherosclerosis) measurements plasma renin activity not taking antihypertensive medications. Coronary calcification was longitudinally assessed using Agatston...
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Frailty is a widely used measure in older patients as predictor of poor outcomes after hospitalization and surgery. There growing body data kidney transplantation suggesting frailty can predict adverse outcomes. interest using chart review measures multimorbidity, they may be equally predictive physical measurement. This approach holds promise for patient evaluation, identifying candidates prehabilitation, targeting resources towards those anticipated to have an increased rate clinical...
Human activities have strongly impacted natural communities through the introduction of non‐native species in historical times. A frequently cited marine example is Littorina littorea , a common intertidal gastropod that was first reported North America 1840. The seemingly sudden appearance and rapid geographical spread this southward from Nova Scotia has led many researchers to consider L. human‐mediated introduction. This despite allozyme subfossil evidence `European periwinkle' long...
People with 59–200 CGG · CCG‐repeats in the 5′ UTR of one their FMR1 genes are at risk for Fragile X tremor and ataxia syndrome. Females also premature ovarian failure. These symptoms thought to be due presence repeats DNA and/or RNA level. We show here that long transcribed but untranslated CGG‐repeat tracts toxic human cells alter expression a wide variety different including caspase‐8, CYFIP, Neurotensin UBE3A.
Aims Alcohol use is associated with both positive and negative effects on individual cardiovascular risk factors, depending upon which factor assessed. The present analysis uses a summative multisystem index of biologic risk, known as allostatic load (AL), to evaluate whether the overall balance alcohol-associated factors may be favorable or unfavorable. Methods This included 1255 adults from Midlife in United States (MIDUS) biomarker substudy. Participants, average age 54.5 (±11) years,...
BACKGROUND/OBJECTIVES The American College of Cardiology (ACC) Geriatric Section Leadership Council recently outlined 4 key domains (which are composed 14 subdomains) that important to assess in older adults with heart failure (HF). We sought determine which geriatric domains/subdomains routinely assessed, how they and impact clinical management the care ambulatory HF. DESIGN Survey. SETTING Ambulatory. PARTICIPANTS Fifteen active ACC member physicians from cardiology community. MEASUREMENTS...
Metformin, a commonly used well-tolerated treatment for type 2 diabetes, is being deployed in clinical trials to ameliorate aging older nondiabetic humans. Concerningly, some experiments model organisms have suggested that metformin use at old ages shortens life span and toxic mitochondria. The demonstrated safety of therapy humans the conflicting data from compelled us test hypothesis would be rats. To define an effective dose 30-month-old hybrid rats, we evaluated two doses (0.1%, 0.75%...
Transcatheter aortic valve replacement (TAVR) is increasingly offered for stenosis (AS) treatment in patients with a history of cancer. The impact frailty on outcomes this specific patient population not well described.Frailty associated mortality and poorer quality life (QOL) undergoing TAVR cancer.This retrospective single center cohort study included AS who underwent from August 1, 2012 to May 15, 2020. Frailty was measured using serum albumin, hemoglobin, gait speed, functional...
An increasing number of older patients are undergoing evaluation for kidney transplantation; however, experience increased rates complications compared with younger patients, leading to the study frailty assessments. Although many centers have evaluated Fried Frailty Phenotype (FFP), less is known about ability Short Performance Physical Battery (SPPB) predict outcomes. assessment by FFP and SPPB was introduced into routine outpatient aged 55 years referred transplantation. Transplant rate,...
Frailty, defined as a state of decreased physiologic reserve, has been correlated with poorer outcomes after hospitalization or surgery. Studies in lung transplant patients have associated frailty an increased risk post-transplant mortality; however, unified approach is lacking. The identification frail can help clinicians pre-emptively target modifiable factors and may facilitate stratification. Frailty Risk Score (FRS) chart review-based based on eight symptoms four laboratory biomarkers....
Frailty status affects outcomes after heart transplantation, but the optimal way to assess frailty prior transplant remains unknown.This single-center, observational study assessed 44 candidates for using three methods. The Short Physical Performance Battery (SPPB) and Fried Phenotype (FFP) were used as two physical assessments of frailty. Risk Score (FRS) was a chart-review based assessment measuring 20 different biopsychosocial functional components, including biomarkers, depression,...