A5103171112- Otitis Media and Relapsing Polychondritis
- Autoimmune and Inflammatory Disorders Research
- Bladder and Urothelial Cancer Treatments
- Vascular Anomalies and Treatments
- Synthesis of Organic Compounds
- Immune Cell Function and Interaction
- Congenital Ear and Nasal Anomalies
- Immunodeficiency and Autoimmune Disorders
- Histiocytic Disorders and Treatments
- Spondyloarthritis Studies and Treatments
- Parvovirus B19 Infection Studies
- Bioactive natural compounds
- Immune responses and vaccinations
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Dermatological and Skeletal Disorders
- Medical Imaging and Pathology Studies
- Food Allergy and Anaphylaxis Research
- Urticaria and Related Conditions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- IgG4-Related and Inflammatory Diseases
- Inflammasome and immune disorders
- Urinary and Genital Oncology Studies
- Hematological disorders and diagnostics
- Inflammatory mediators and NSAID effects
Kōchi University
2016-2024
Kochi Medical School Hospital
2016-2021
Center for Rheumatology
2018
Tokyo University of Marine Science and Technology
2011
Josai University
1980
Adult-onset Still disease (AOSD), a systemic inflammatory disorder, is characterized by high fever, evanescent rash, arthritis, and hyperferritinaemia. AOSD also reported to be associated with other skin lesions, including persistent pruritic papules plaques. This study aimed assess the significance of dyskeratotic lesions in Japanese patients.We retrospectively assessed histology rashes relationship between cells, serum markers, outcomes 20 patients, comparing that dermatomyositis (DM),...
ABSTRACT Background Zeb2, a zinc finger E-box-binding homeobox transcription factor, regulates transforming growth factor (TGF)-β signaling pathway. However, its role in the pathogenesis of acute kidney injury (AKI) and AKI-to-chronic disease (CKD) transition is unclear. Methods We evaluated Zeb2 function bilateral renal ischemia–reperfusion (IRI)-induced AKI model using proximal tubule-specific conditional knockout (Zeb2-cKO) wild-type (WT) mice, biopsy samples. Results In Zeb2-cKO levels...
Reactive arthritis (ReA) is a sterile that occurs in genetically predisposed individuals secondary to an extra-articular infection, usually of the gastrointestinal or genitourinary tract. Sterile associated with instillation intravesical bacillus Calmette-Guérin (iBCG) therapy used for bladder cancer can also be included under ReA based on pathogenic mechanism. Similar spondyloarthritis, HLA-B27 positivity known contributor genetic susceptibility underlying iBCG-associated ReA. Other...
Abstract Aim To assess the clinical utility of ultrasonography in diagnosis and monitoring disease activity relapsing polychondritis (RP). Methods Auricular nasal chondritis 6 patients with RP were assessed by before treatment initiation. Changes ultrasonographic findings serum inflammatory markers longitudinally assessed. Ultrasonography was also performed repeat ear trauma, auricular cellulitis healthy controls for comparison among groups. Results In all cases RP, revealed low‐echoic...
<h3>Background</h3> Relapsing polychondritis (RP) is a rare systemic inflammatory disorder and might often be refractory. Therefore, the discovery of more convenient imaging modality than contrast-CT, MRI FDG-PET/CT would required on diagnosis treatment. <h3>Objectives</h3> To assess clinical implications ultrasonography (US) in monitoring disease activity relapsing (RP). <h3>Methods</h3> Firstly, auricular chondritis patients with RP (n=5) were assessed by US before after treatments....
<h3>Background</h3> Adult-onset Still's disease <b>(</b>AOSD) is an acute and systemic inflammatory disorder that characterised by high spiking fever, evanescent rash, arthralgia/arthritis hyperferritinemia. However, recent reports showed not only typical salmon-coloured rash but also atypical skin lesions, persistent pruritic papules plaques, could be associated with AOSD. <h3>Objectives</h3> To assess the clinical significance of dyskeratotic cells (DCs) in lesions <h3>Methods</h3> We...
<h3>Background</h3> Relapsing polychondritis (RP) is a rare systemic inflammatory disorder and might often be refractory. Therefore, the discover of imaging modality would required on diagnosis treatment RP. <h3>Objectives</h3> To assess clinical implications ultrasonography (US) in monitoring disease activity relapsing (RP). <h3>Methods</h3> Three cases 78-year-old man with RP, 74-year-old woman RP associated optic perineuritis 42-year-old uveitis were assessed by US before after...
<h3>Background</h3> Intravesical instillation of Bacillus Calmette-Guerin (iBCG) is used as an effective immunotherapy bladder cancer. However it may have, adverse event, a reactive arthritis (ReA) and the frequencies are known about 0.5 to 1% in Western countries. <h3>Objectives</h3> To evaluate HLA phenotype (ReA), uveitis, conjunctivitis other events Japanese patients with cancer following iBCG therapy. <h3>Methods</h3> The clinical findings who received (n=555 [250 305 Kochi Medical...
<h3>Background</h3> Adult-onset Still9s disease (AOSD) is an acute and systemic inflammatory disorder that characterized by high spiking fever, evanescent rash, arthralgia/arthritis hyperferritinemia. However, recent reports showed not only typical salmon-colored rash but also atypical skin lesions, persistent pruritic papules plaques, could be associated with AOSD. <h3>Objectives</h3> The aim of this study to assess the clinical significance dyskeratotic cells in lesions Japanese patients...
<h3>Background</h3> The prevalence rate of PPP in Japan is somewhat as 0.13%<sup>1)</sup> , accounting for 61% cutaneous manifestations diseases associated with SAPHO syndrome<sup>2)</sup> . syndrome<sup>3)</sup> not a new disease concept which the cause has been clarified but name that classified diseased groups by collecting known diseases. On other hand, PAO "proper subset" syndrome and smallest unit concept. Therefore, detailed information on was sought. <h3>Objectives</h3> To examine...