A5101647203- Diabetes Management and Research
- Diabetes Treatment and Management
- Retinal and Macular Surgery
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Pancreatic function and diabetes
- Pharmacology and Obesity Treatment
- Diabetes Management and Education
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Retinal and Optic Conditions
- Alcoholism and Thiamine Deficiency
- Chronic Disease Management Strategies
- Cardiac Imaging and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Interprofessional Education and Collaboration
- Ophthalmology and Eye Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Gastrointestinal disorders and treatments
- Diet and metabolism studies
- Spondyloarthritis Studies and Treatments
- Neurological Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
Sanno Medical Center
2016-2025
International University of Health and Welfare
2017-2023
St. Luke's International Hospital
2010-2021
National Center for Global Health and Medicine
2010-2016
Center for Global Health
2010-2016
Diabetes Research Center
2016
Jichi Medical University
2014
Toyama University Hospital
2009-2010
Saitama International Medical Center
2007-2009
Toranomon Hospital
2007
Abstract: Dipeptidyl peptidase-4 (DPP-4) inhibitors have recently emerged as a new class of antidiabetic that show favorable results in improving glycemic control with minimal risk hypoglycemia and weight gain. Teneligliptin, novel DPP-4 inhibitor, exhibits unique structure characterized by five consecutive rings, which produce potent long-lasting effect. Teneligliptin is currently used cases showing insufficient improvement even after diet exercise or combination control, exercise,...
OBJECTIVE To assess vital signs, QT intervals, and newly diagnosed cardiovascular disease during severe hypoglycemia in diabetic patients. RESEARCH DESIGN AND METHODS From January 2006 to March 2012, we conducted a retrospective cohort study type 1 2 patients with at national center Japan. Severe was defined as the presence of any hypoglycemic symptoms that could not be resolved by themselves prehospital settings. RESULTS A total 59,602 cases visited emergency room ambulance were screened,...
Amid the coronavirus disease (COVID-19) pandemic, Japanese government declared a state of emergency and urged people to stay at home prevent transmission. Herein, we investigated this situation's effect on diabetes patients' lifestyle glycemic control.Diabetes patients who visited our hospital between April 1 June 13, 2020, for regular consultation were asked about changes in their physical activities dietary habits during period.Among 168 patients, 26 (15.5%) gained > 2 kg; HbA1c levels...
The present study examined the clinical conditions and predictors of death in non-diabetic patients with pre-hospital severe hypoglycemia.From January 2006 to March 2012, we retrospectively reviewed medical records assess hypoglycemia at a national center Japan. Severe was defined as presence any hypoglycemic symptoms requiring assistance another person. were followed up for 90 days after episode.A total 59,602 consecutive cases that visited emergency room screened, 530 included subsequent...
Insulin therapy represents the most effective and reliable means of achieving satisfactory glycemic control. However, few studies have evaluated predictors future insulin use. The purpose this study was to investigate use in type 2 diabetic patients. In study, we conducted a chart review 158 Japanese patients admitted our hospital for stringent Of subjects, 92 satisfied inclusion criteria study. We assessed associations between baseline BMI, fasting plasma glucose levels (FPG) serum urinary...
Various autoimmune diseases, especially thyroid disease, are known to occur in HIV-infected patients on highly active antiretroviral therapy (HAART). However, no reports have described the development of diabetes during HAART.Our objective was investigate clinical course autoantibodies and HAART.Based their high antiislet autoantibody titers requirement for insulin therapy, we diagnosed three with diabetes. To clarify relationship between an reaction against pancreatic beta-cells recovery...
Blood glucose control in patients with diabetes mellitus (DM) is reportedly influenced by the seasons, hemoglobin A1c (HbA1c) levels decreasing summer or warm season and increasing winter cold season. In addition, several studies have shown that sepsis also associated seasons. Although both blood can strongly affect occurrence of severe hypoglycemia, few examined seasonal variation hypoglycemia. The aim present study to examine association between hypoglycemia seasons type 1 (T1DM), 2...
Effective communication is crucial for supporting people with diabetes, yet many medical staff feel unsure about their skills in this area. We evaluated role-playing seminars as a method to improve among staff. From 2008 2024, we conducted 78 2,458 participants, including nurses, dietitians, and pharmacists. Participants engaged realistic simulated scenarios based on common clinical situations of patient-medical interactions, taking roles patients (patient performers), (medical observers....
A 55-year-old Japanese man was admitted to our hospital with severe weakness. Without measurement of serum electrolyte concentrations, diuretic therapy for hypertension started 2 weeks prior admission. Laboratory findings showed profound hypokalemia (1.4 mEq/L), and extreme elevation the creatinine phosphokinase levels (15,760 IU/L), suggesting that patient had hypokalemic paralysis hypokalemia-induced rhabdomyolysis. Further evaluations, including adrenal venous sampling strongly suggested...
Nerve excitability test, intensity-duration curve, and measurements of action potentials evoked by facial nerve stimulation (evoked electromyography) were made on 146 patients, ie, 117 with Bell's palsy, 14 Ramsay Hunt's syndrome, 15 traumatic palsy. Surgical decompressions performed 34 patients. Long-term follow-up studies indicated that electromyography was valuable for detecting minor incipient denervation. By collating these three electrodiagnostic results, accurate differentiation could...
Glucose fluctuations including robust postprandial hyperglycemia are a risk for promoting atherosclerosis and diabetic complications. The α-glucosidase inhibitors the dipeptidyl peptidase-4 (DPP-4) have been found to effectively decrease independently. Therefore, glycemic control with combination of these drugs is warranted. Continuous glucose monitoring (CGM) was performed 3 patients type 2 diabetes 1 subject from beginning end study. Medications were not administered any subjects on first...
Glycated hemoglobin (HbA1c) and glycated albumin (GA) are frequently used as glycemic control markers. These markers influenced by either altered metabolism or metabolism. We investigated the correlation between HbA1c GA collecting only data that had not been affected turnover of proposed a novel equation for accurately estimating extrapolated (eHbA1c) value based on value. Data sets total 2461 occasions were obtained from 731 patients (including non-diabetes patients) whose values...
Type 1 diabetes mellitus is classified as either autoimmune or idiopathic. Fulminant type was originally reported a subtype of idiopathic diabetes. Though involvement viral infections has been suggested triggering mechanism, its pathogenesis remains unknown. Here, we present case fulminant associated with significant elevation mumps titers. A 56-year-old Japanese man had suffered from nausea and generalized fatigue for two days before being transferred to our hospital in confused state....
Background. Several studies have suggested that the occurrence of severe hypoglycemia during sleep may be more dangerous for cardiac arrhythmia than in day-time.Methods. We performed a retrospective study between January 2006 and March 2012 to assess electrocardiograms patients with or without diabetes.Results. A total 59,602 who visited emergency room by ambulance were screened, 287 enrolled. The median blood glucose levels (DM, n = 192) diabetes (non-DM, 95) 30 45 mg/dL, respectively....
Recent studies have suggested that microvascular and macrovascular diseases are associated with coronary events.To test the hypothesis asymptomatic heart disease (CHD) may be present in many patients diabetes vascular complications.From April 2009 to August 2010, authors conducted a cross-sectional study assess prevalence of CHD among type 2 complications at national centre Japan. Eligibility criteria included no known one or more following four criteria: (1) proliferative diabetic...
Glucagon-like peptide-1 (GLP-1) receptor agonists can maintain good glycemic control in some diabetic. Here we compared the clinical characteristics and parameters reflecting glucose metabolism at time of initiation GLP-1 agonist therapy between patients who responded well to those did not. The records 43 with type 2 diabetes started receiving during hospitalization were retrospectively reviewed. Glucagon stimulation tests performed, on liraglutide or exenatide therapy. Preprandial blood...
Diabetes is a multifactorial disease and its nature means that interprofessional teamwork essential for treatment. However, in general, has certain problems impede function. To clarify these relation to diabetes care, questionnaire survey was conducted.The participants who were involved diabetes-related educational seminars, medical personnel engaged care from the National Center Global Health Medicine, asked complete about perceptions of, satisfaction with, across multiple health providers,...
Ezetimibe selectively inhibits dietary and biliary cholesterol absorption reduces serum levels when administered alone (monotherapy) along with common lipid-regulating agents (combination therapy). To evaluate the effect of ezetimibe therapy on lipid profile, glucose metabolism, synthesis markers, we 10 mg to 50 hypercholesterolemic patients or without diabetes. The low-density lipoprotein total were significantly reduced at 4 12 weeks in diabetic both monotherapy combination-therapy groups...
Preface The Great East Japan Earthquake and subsequent tsunami destroyed large parts of Japan's Tohoku district. Special efforts were made regarding the prompt distribution medical supplies, including insulin, for diabetic patients. However, many patients in shelters lost their blood glucose control as a result unfavorable living environment. high‐calorie food provided led to severe postprandial hyperglycemia. Furthermore, mental stress can aggravate these require special care. We have few...
Excessive iron storage sometimes causes diabetes in patients with hemochromatosis, a disease caused by overloading. We performed an immunohistochemical analysis to study autopsy case of aplastic anemia and diabetic hemochromatosis frequent blood transfusions, extensive hemosiderin deposition was observed the liver pancreas. The pancreatic islets patient control subject were stained detect glucagon, insulin, proinsulin. Significantly lower levels immunoreactivity both insulin antibodies...
Carbohydrate-restricted diets are prevalent not only in obese people but also the general population to maintain appropriate body weight. Here, we report that extreme carbohydrate restriction for one day affects subsequent blood glucose levels healthy adults. Ten subjects (median age 30.5 years, BMI 21.1 kg/m2, and HbA1c 5.5%), wearing with a continuous monitoring device, were given isoenergetic test meals 4 consecutive days. On 1, 2 (D2), (D4), they consumed normal-carbohydrate (63-66%...
The study aimed to identify predictors of severe acute hypertension (≥180/110 mmHg) during hypoglycemia and assess the efficacy prior use catecholamine-blocking agents for preventing adverse influences in diabetic patients with hypoglycemia. We performed a retrospective between January 2006 March 2012 at single center Japan. Severe was defined as presence any hypoglycemic symptoms that required medical assistance another person after visiting emergency room by ambulance. Multivariate...
The 16q12.2 locus in the first intron of FTO has been robustly associated with body mass index (BMI) and type 2 diabetes genome-wide association studies (GWAS). To improve resolution fine-scale mapping at FTO, we performed a systematic approach consisting two parts.The part is to partition variants into linkage disequilibrium (LD) clusters, followed by conditional haplotype analyses. second filter list potential causal through trans-ethnic comparison.We examined LD relationship between SNPs...