A5018659601- Syphilis Diagnosis and Treatment
- HIV/AIDS oral health manifestations
- Reproductive tract infections research
- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
- Animal Disease Management and Epidemiology
- Sex work and related issues
- Mycobacterium research and diagnosis
- Dermatological diseases and infestations
- Acne and Rosacea Treatments and Effects
- Fungal Infections and Studies
- Oral microbiology and periodontitis research
- Brucella: diagnosis, epidemiology, treatment
- Pelvic and Acetabular Injuries
- Ocular Infections and Treatments
- Parasitic Diseases Research and Treatment
- Menstrual Health and Disorders
- Parvovirus B19 Infection Studies
- Silk-based biomaterials and applications
- Hip and Femur Fractures
- Urinary Tract Infections Management
- Cardiac, Anesthesia and Surgical Outcomes
- Vector-Borne Animal Diseases
- Zoonotic diseases and public health
- Hair Growth and Disorders
London School of Hygiene & Tropical Medicine
2018-2025
Croydon University Hospital
2024
John Radcliffe Hospital
2024
University of London
2020-2023
In the peri-elimination setting, positive predictive value of trachomatous inflammation-follicular (TF), primary marker used to determine need for antibiotics trachoma, is suboptimal. Here, three non-TF measures are compare two regions where TF prevalence exceeds threshold intervention, but Chlamydia trachomatis (Ct) different.Population trachoma was measured in Vanuatu (n = 3470) and Kiribati 2922). Dried blood spots (DBS) conjunctival photographs were collected from every survey...
Background Integrated approaches to mapping skin Neglected Tropical Diseases (NTDs) may be cost-effective way guide decisions on resource mobilization. Pilot studies have been carried out, but large-scale data covering multiple countries endemic for NTDs are lacking. Within the LAMP4YAWS project, we collected integrated burden of NTDs. Methods From March 2021 2023, case searches yaws alongside other conditions were performed in health districts Cameroon, Côte d’Ivoire, and Ghana. activities...
Yaws, caused by the bacterium Treponema pallidum subsp. pertenue, is a neglected tropical disease targeted for eradication 2030. Improved diagnostics will be essential to meet this goal. Diagnosis of yaws has relied heavily on clinical and serological tools. However, presence coendemic cutaneous skin ulcer diseases, such as lesions Haemophilus ducreyi (HD), means these techniques do not provide reliable diagnosis. Thus, new diagnostic tools are needed. Molecular PCR ideal, but often...
In the Solomon Islands and Vanuatu, sign trachomatous inflammation-follicular (TF) is common, but ocular infection with Chlamydia trachomatis not. It therefore debatable whether azithromycin mass drug administration (MDA), recommended antibiotic treatment strategy for trachoma's elimination as a public health problem, necessary in this setting. We set out to estimate what proportion of adolescents were at risk progression scarring.A cross-sectional survey was undertaken all children aged...
Cutaneous ulcers are common in yaws-endemic areas. Although often attributed to ' Treponema pallidum subsp. pertenue' and Haemophilus ducreyi , quantitative PCR has highlighted a significant proportion of these negative for both pathogens considered idiopathic. This is retrospective analysis utilising existing 16S rRNA sequencing data from two independent yaws studies that took place Ghana the Solomon Islands. We characterized bacterial diversity 38 samples identify potential causative...
Introduction A multidisciplinary team (MDT) approach to polytrauma patients minimises morbidity and mortality. This project assesses the extent which British Orthopaedic Association Standards for Trauma guidelines management of frail patient are currently being met. Methods retrospective analysis was performed all in multiple medical institutions over a 2-week capture period from 1 March 2022 until 14 inclusive. Data collected included age, sex, injury, length stay dates speciality input....
Background Yaws, caused by Treponema pallidum subsp. pertenue , is a skin neglected tropical disease. It targeted for eradication 2030, primarily using mass drug administration (MDA) with azithromycin. Traditionally, diagnosis of yaws has relied on clinical examination and serological testing. However, these approaches have poor diagnostic performance. To achieve eradication, more accurate diagnostics are required to determine whether MDA should be initiated or continued as well...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Yaws, caused by Treponema pallidum ssp. pertenue , remains a significant public health concern in tropical regions of West Africa and the South Pacific, primarily affecting children remote areas with limited access to hygiene sanitation. In this study, conducted three endemic countries where yaws (Ghana, Cameroon, Côte d’Ivoire), we aimed assess knowledge, attitudes, practices related among community members, workers (CHWs), traditional healers. The study revealed variations perception...
Yaws is a neglected tropical disease targeted for eradication by 2020. Kiribati, Pacific Island nation, was previously endemic yaws but lacks recent data from which its current endemicity status could be determined. This study tested antibody responses to Treponema pallidum determine if transmission of taking place among children in Kiribati. Using commercially available T. particle agglutination kit (Serodia®, Fujirebio Inc., Tokyo, Japan), we dried blood spots, collected during...
Yaws is a neglected tropical disease and results in lesions of skin, soft tissues bones. PCR plays an important part surveillance.Children suspected to have yaws were enrolled. From the largest lesion, paired swabs collected, one transport medium as dry swab. In children with multiple we collected additional from up four subsequent lesions. Swabs maintained cold chain while stored at ambient temperature. tested by for Treponema pallidum Haemophilus ducreyi.Of 55 individuals, 10 (18%) had...
Yaws is targeted for eradication by 2030, using a strategy based on mass drug administration (MDA) with azithromycin. New diagnostics are needed to aid eradication. Serology currently the mainstay yaws diagnosis; however, inaccuracies associated current serological tests makes it difficult fully assess need and impact of campaigns these tools. Under recommendation WHO Diagnostic Technical Advisory Group (DTAG) Neglected Tropical Diseases(NTDs), working group was assembled tasked agreeing...
Abstract Background Integrated approaches to mapping skin Neglected Tropical Diseases (NTDs) may be cost-effective way guide decisions on resource mobilization. Pilot studies have been carried out, but large-scale data covering multiple countries endemic for skin-NTDs are lacking. Within the LAMP4YAWS project, we collected integrated burden of skin-NTDs. Methods From March 2021 2023, case searches yaws alongside other conditions were performed in health districts Cameroon, Côte d’Ivoire, and...
Abstract Background Yaws, caused by Treponema pallidum subsp. pertenue , is a skin neglected tropical disease. It targeted for eradication 2030, primarily using mass drug administration (MDA) with azithromycin. Traditionally, diagnosis of yaws has relied on clinical examination and serological testing. However, these approaches have poor diagnostic performance. To achieve eradication, more accurate diagnostics are required to determine whether MDA should be initiated or continued as well...