A5071250713- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hemostasis and retained surgical items
- Appendicitis Diagnosis and Management
- Hernia repair and management
- Abdominal Surgery and Complications
- Surgical Sutures and Adhesives
- Cardiac Ischemia and Reperfusion
- Liver Disease Diagnosis and Treatment
- Intestinal and Peritoneal Adhesions
- Hepatitis C virus research
- Mitochondrial Function and Pathology
- Burn Injury Management and Outcomes
- Adenosine and Purinergic Signaling
- Abdominal Trauma and Injuries
- Wound Healing and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Urological Disorders and Treatments
- Injury Epidemiology and Prevention
- Electrospun Nanofibers in Biomedical Applications
- Veterinary Pharmacology and Anesthesia
- Drug-Induced Hepatotoxicity and Protection
- Tissue Engineering and Regenerative Medicine
- Blood transfusion and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
RWTH Aachen University
2011-2018
Universitätsklinikum Aachen
2017
Kanchi Kamakoti CHILDS Trust Hospital
2014
Several decades ago, the beneficial effects of goal-directed therapy, which include decompressive laparotomy (DL) and open abdomen procedures in cases intra-abdominal hypertension (IAH) children, were proven context closures abdominal wall defects large-for-size organ transplantations. Different neonatologic pediatric disease patterns are also known to be capable increasing pressure (IAP). Nevertheless, a considerable knowledge transfer regarding such risk factors has hardly taken place....
The purpose of the present study was to quantify bacterial translocation mesenteric lymph nodes due different levels intra-abdominal hypertension (IAH; 15 vs. 30 mmHg) lasting for 24 h in a porcine model. We examined 18 anesthetized and intubated pigs (52.3 ± 4.7 kg) which were randomly allocated three experimental groups (each n = 6) studied over period h. After preparation establishing steady state, pressure (IAP) increased stepwise mmHg six animals using carbon dioxide (CO2) insufflator...
The increasing shortage of donor organs has led to the use from non-heart-beating donors. We aimed assess impact venous systemic oxygen persufflation (VSOP) supplemented with nitric oxide (NO) gas during cold storage (CS) warm ischemia (WI)-damaged experimental liver grafts. Rat livers (n = 5 per group) were retrieved after 30 minutes WI induced by cardiac arrest (the and thereafter preserved for 24 hours CS in histidine tryptophan ketoglutarate solution. During CS, gaseous was insufflated...
<b><i>Background:</i></b> Topical hemostatic agents are useful when hepatic hemorrhage is difficult to control. The aim of this study was evaluate the efficacy and safety a biodegradable polyurethane-based adhesive, MAR VIVO-107 (MAR), in comparison with clinically used fibrin glue. <b><i>Methods:</i></b> Thirty female New Zealand white rabbits were randomly assigned 3 groups as follows: (<i>n</i> = 10), glue saline 10). After...
The repair of urinary bladder tissue is a necessity for loss due to cancer, trauma, or congenital abnormalities. Use intestinal still the gold standard in urological clinic, which leads new problems and dysfunctions like mucus production, stone formation, finally malignancies. Therefore, use artificial, biologically derived materials promising step towards augmentation this specialised tissue. aim study was investigate potential wall by two collagen scaffold prototypes, OptiMaix 2D 3D, naïve...
Despite modern surgical techniques, insufficient hemostasis after liver trauma is still a major cause of morbidity and mortality injury. Therefore, efficient hemostatic agents are indicated. In this study, we evaluated the efficacy novel synthetic wound adhesive (MAR-VIVO-107) based on polyurethane/polyurea, compared with widely used fibrin (Tisseel).Twelve German Landrace pigs were randomly assigned to 2 groups. The animals operated under sterile conditions. A midline laparotomy was...
Abdominal compartment syndrome (ACS) is a life threatening condition that may affect any critically ill patient. Little known about the recognition and management of ACS in Germany. A questionnaire was mailed to departments surgery anesthesia from German hospitals with more than 450 beds. Replies (113) were received 222 eligible (51%). Most respondents (95%) indicated plays role their clinical practice. Intra-abdominal pressure (IAP) not measured at all by 26%, while it routinely done 30%....
Due to the drastic shortage of organ donors, clinicians are increasingly considering use deceased after cardiac death donors (DCD). Compatible solutes like Ectoine and Hydroxyectoine produced by extremophilic bacteria as a cell protectant survive in harsh environments. We hypothesized that addition Histidine-Tryptophan-Ketoglutarate solution (HTK) could ameliorate cold ischemic preservation injury DCD livers.Rat livers were harvested from male Wistar rats weighing 250-300 g. Three...
To compare a novel, fully synthetic, polyurethane based glue (MAR-1) to fibrin sealant in partial liver resection rat model.After 50% of the lateral left lobe male Wistar rats (n = 7/group/time point), MAR-1, Fibrin or NaCl was applied. After 14, 21 and 90 postoperative days, degradation, intra-abdominal adhesions were scored, histological examination tissue performed.(Mean ± SEM) (MAR-1 vs NaCl). Bleeding mass significantly higher (3.36 0.51 g) compared MAR-1 (1.44 0.40 (1.16 0.32 g). At 14...
Severity assessment in biomedical research is required by the European authorities. Therefore, a variety of score sheets are available. The first were designed and introduced Morton Griffith (M&G) 1985, to assess pain distress animals. Score an important part 3R principles evaluate degree severity different studies. Here, we used modified sheet from M&G for 12 Aachen minipigs after partial liver resection safety testing novel synthetic sealant (VIVO-107). control group was treated...
Objectives: To investigate the role of CGS21680, a selective adenosine A2A receptor agonist, on bile-duct-ligated cirrhotic liver resection model in rats. Methods: Male Wistar rats were allotted into 3 groups (n = 7 per time-point): control group, bile duct ligation + CGS21680 group (BDL CGS), and (BDL). Biliary cirrhosis had been previously induced by ligature common BDL CGS groups. After 2 weeks, animals underwent partial hepatectomy (50%). The received single dose 15 minutes prior to...
<b><i>Background/Aim:</i></b> Worldwide shortage of donor organs has increased the use donation after cardiac death (DCD). The aim this study was to analyze best time point for venous systemic oxygen persufflation (VSOP) supplemented with nitric oxide (NO) gas during 1st and 24th hour cold storage (CS) in warm ischemia (WI)-damaged experimental liver grafts. <b><i>Materials Methods:</i></b> Liver grafts (n = 5) were retrieved 30 min WI induced...