A5010588806- Redox biology and oxidative stress
- Nanoplatforms for cancer theranostics
- Vitamin D Research Studies
- Click Chemistry and Applications
- Heat shock proteins research
- Melanoma and MAPK Pathways
- RNA modifications and cancer
- MicroRNA in disease regulation
- Thyroid Disorders and Treatments
- Ophthalmology and Eye Disorders
- Protein Tyrosine Phosphatases
- Phagocytosis and Immune Regulation
- Drug Transport and Resistance Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Adenosine and Purinergic Signaling
- Thyroid Cancer Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis B Virus Studies
- Inflammasome and immune disorders
- Cancer-related gene regulation
- Hippo pathway signaling and YAP/TAZ
Ewha Womans University
2013-2018
Kookmin University
2014
In melanoma, transition to the vertical growth phase is critical step in conversion a deadly malignant disease. Here, we offer first evidence that an antioxidant enzyme has key role this transition. We found peroxiredoxin-2 (Prx2) inversely correlated with metastatic capacity of human melanoma cells. Silencing Prx2 expression stimulated proliferation and migration, whereas ectopic produced opposite effect. Mechanistic investigations indicated negatively regulated Src/ERK activation status,...
Abstract Multidrug resistance 3 (MDR3), encoded by the ATP-binding cassette, subfamily B, member 4 gene ( ABCB4 ), localizes to canalicular membrane of hepatocytes and translocates phosphatidylcholine from inner leaflet outer membrane. Progressive familial intrahepatic cholestasis type (PFIC3) is a rare hepatic disease caused genetic mutations . In this study, we characterized 8 found in PFIC3 patients, using vitro molecular assays. First, examined transport activity each mutant measuring...
Purpose: This study was conducted to identify and functionally characterize genetic variants in ST3GAL5 ST8SIA1 Korean patients with thyroid-associated ophthalmopathy (TAO).Materials Methods: Genetic analyses were using DNA samples from TAO (n=50) healthy subjects (n=48) TAO-specific of or ST8SIA1.The effect each variant on the transcription expression these genes examined.Additionally, correlations between functional haplotypes clinical characteristics investigated.Results: Six promoter one...
Src homology 2 domain-containing protein tyrosine phosphatase (SHP-2) is a cytoplasmic that highly expressed in hematopoietic cells and the CNS exerts opposite effects on signal transduction by exerting neuroprotective or proapoptotic effect. Several mutations of SHP-2 have been found children with myeloproliferative disorders malignant leukemia, some these can affect brain development. In present study, we aimed to identify functionally characterize genetic variations 72 preterm 58...
Background: Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease.To date, large number of clinical studies have been conducted to investigate the association between genetic variations and COPD.However, little known regarding susceptibility Koreans this disease.MER receptor tyrosine kinase (MERTK) plays important roles in inhibition inflammation clearance apoptotic cells.Here, we investigated MERTK development COPD Koreans.Methods: We analysis using genomic DNA samples...
<p>Supplementary Figure S2�- PDF file 425K, Peroxidase activity of Prx2 is essential for regulating melanoma cell function</p>
<p>Supplementary Figure S1�- PDF file 821K, Expression status of Prx1 or Prx2 in melanoma cells</p>
<p>Supplementary Figure S3 -�PDF file 79K, Quality control of antibodies against adherens junctional proteins</p>
<p>Supplementary Figure Legends�- PDF file 151K, Legend for Supplementary Figures S1-S5</p>
<p>Supplementary Figure S5 -�PDF file 14K, Cytotoxicity test of GT in melanoma cells</p>
<p>Supplementary Figure S1�- PDF file 821K, Expression status of Prx1 or Prx2 in melanoma cells</p>
<p>Supplementary Figure Legends�- PDF file 151K, Legend for Supplementary Figures S1-S5</p>
<p>Supplementary Figure S2�- PDF file 425K, Peroxidase activity of Prx2 is essential for regulating melanoma cell function</p>
<p>Supplementary Figure S5 -�PDF file 14K, Cytotoxicity test of GT in melanoma cells</p>
<p>Supplementary Figure S4 -�PDF file 1782K, The E-cadherin expression and �-catenin retention in plasma membrane is controlled independently via ERK Src pathways</p>
<p>Supplementary Figure S3 -�PDF file 79K, Quality control of antibodies against adherens junctional proteins</p>
<p>Supplementary Figure S4 -�PDF file 1782K, The E-cadherin expression and �-catenin retention in plasma membrane is controlled independently via ERK Src pathways</p>
<div>Abstract<p>In melanoma, transition to the vertical growth phase is critical step in conversion a deadly malignant disease. Here, we offer first evidence that an antioxidant enzyme has key role this transition. We found peroxiredoxin-2 (Prx2) inversely correlated with metastatic capacity of human melanoma cells. Silencing Prx2 expression stimulated proliferation and migration, whereas ectopic produced opposite effect. Mechanistic investigations indicated negatively regulated...
<div>Abstract<p>In melanoma, transition to the vertical growth phase is critical step in conversion a deadly malignant disease. Here, we offer first evidence that an antioxidant enzyme has key role this transition. We found peroxiredoxin-2 (Prx2) inversely correlated with metastatic capacity of human melanoma cells. Silencing Prx2 expression stimulated proliferation and migration, whereas ectopic produced opposite effect. Mechanistic investigations indicated negatively regulated...