A5007237037- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sperm and Testicular Function
- Sexual Differentiation and Disorders
- Diabetes Treatment and Management
- Peptidase Inhibition and Analysis
- Neuropeptides and Animal Physiology
- Forensic and Genetic Research
- Genomics and Chromatin Dynamics
- Genetic Associations and Epidemiology
- Ubiquitin and proteasome pathways
- Muscle metabolism and nutrition
- Genetic diversity and population structure
- Metabolism, Diabetes, and Cancer
- Hormonal and reproductive studies
- Chemical Synthesis and Analysis
- Pharmacological Effects of Natural Compounds
- Genetic and phenotypic traits in livestock
- Adipose Tissue and Metabolism
- Click Chemistry and Applications
- Reproductive Biology and Fertility
- Biochemical Acid Research Studies
- Hypothalamic control of reproductive hormones
- Aldose Reductase and Taurine
- Pancreatitis Pathology and Treatment
- Biotin and Related Studies
Tokushima University
2014-2024
Institute of Biomedical Science
2016-2021
Japan Aerospace Exploration Agency
2012
Saitama Medical University Hospital
2011
Sakurabashi Watanabe Hospital
2010
Health and Human Development (2HD) Research Network
2008-2010
Iwate Biotechnology Research Center
2009
In-Q-Tel
2009
Japan Science and Technology Agency
2007
Public Health Institute
2006
The aim of this study was to determine whether cinnamon extract (CE) would improve the glucose utilization in normal male Wistar rats fed a high-fructose diet (HFD) for three weeks with or without CE added drinking water (300 mg/kg/day). In vivo measured by euglycemic clamp technique. Further analyses on possible changes insulin signaling occurring skeletal muscle were performed afterwards Western blotting. At 3 mU/kg/min infusions, decreased infusion rate (GIR) HFD-fed (60 % controls, p <...
Examination of the EtOH extract fruiting bodies Terminalia chebula RETZ. led to isolation two potent antimicrobial substances against even methicillin-resistant strains Staphylococcus aureus. On basis spectroscopic evidence, isolates have been identified as gallic acid and its ethyl ester.
We examined the role of dipeptidyl peptidase IV (DPP4) in development diabetes, dyslipidaemia and renal dysfunction induced by streptozotocin (STZ). F344/DuCrlCrlj rats, which lack DPP4 activity, wild-type rats were treated with STZ. Plasma activity biochemical parameters measured until 42 days after STZ treatment. At end experiment, function expressions kidney, liver, pancreas adipose tissues determined. Increases blood glucose, cholesterol triglycerides evoked both rat strains; however,...
We previously found that plasma dipeptidyl peptidase 4 (DPP4) activity was associated with the development of obesity, type 2 diabetes, and 1 diabetes using animal models. In this study, we investigated whether DPP4 is correlated clinical parameters obesity and/or in healthy young subjects. Body mass index (BMI), activity, total cholesterol, high density lipoprotein (HDL) triglycerides, fasting blood glucose, adiponectin concentration, body fat were measured 165 subjects (110 males 55...
Are the four candidate loci (rs7867029, rs7174015, rs12870438 and rs724078) for human male fertility traits, identified in a genome-wide association study (GWAS) of Hutterite population USA, associated with infertility Japanese population? rs7867029, rs7174015 are significantly risk population. Recently, GWAS USA revealed that 41 single-nucleotide polymorphisms (SNPs) were correlated family size or birth rate. Of these, SNPs found to be semen parameters ethnically diverse men from Chicago....
Abstract This study was conducted to find constituents of an annual herb, Xanthium sibiricum Patr er Widd, with effective antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). By monitoring MRSA strains, it shown that a sesquiterpene lactone, identified as [3aR-(3aα,7β,8aβ)]-3,3a,4,7,8,8a-hexahydro-7-methyl-3-methylene-6-(3-oxo-1-butenyl)-2H-cyclohepta[b]furan-2-one, or xanthatin, isolated from leaves the had outstandingly potent S. species, including MRSA; its...
Altered dipeptidyl peptidase-4 (DPP4) activity during the progression of late-stage type 2 diabetes was measured in Otsuka Long-Evans Tokushima fatty (OLETF) rats. Compared with OLETF rats subjected to 30% food restriction, food-satiated exhibited spontaneous hyperphagic obesity, insulin resistance, hyperglycemia, hyperinsulinemia, and increased plasma DPP4 early phase experiment (up ∼30 wk). Subsequently, their as well body weight, fat, concentration declined control levels late phase,...
Several studies have investigated whether particular Y chromosome haplogroups are associated with spermatogenic failure in Japanese males; however, they produced differing results. In this study, to investigate the association of haplogroup failure, we recruited 451 infertile patients and 730 fertile men from a population typed their haplogroups. The were suffering varicocele, azoospermia, oligozoospermia, asthenozoospermia, obstructive karyotype abnormalities, microdeletions long arm...
The ligand-dependent incorporation of a reporter molecule (e.g., fluorescence dye or biotin) onto endogenous target protein has emerged as an important strategy for elucidating function using various affinity-based labelling reagents consisting reporter, ligand and reactive units. Conventional generally use weakly activated unit, which can result in the non-specific proteins ligand-independent manner. In this context, activation reagent through targeted protein-ligand interaction could...
Several studies have investigated whether dipeptidyl peptidase IV (DPP IV) activity is correlated to the severity of diabetes; however, it remains unclear. To investigate roles DPP in metabolic abnormalities, impaired glucose tolerance rats were produced using a high-fat (HF) or high-sucrose (HS) diet. HF diet-fed obviously exhibited tolerance, with increases subcutaneous and epididymal fat mass, insulin resistance dyslipidaemia. In fed HS diet rather than normal diet, lower body weight...
Obesity as well its associated chronic diseases and adverse health consequences such type 2 diabetes mellitus, dyslipidemia, hypertension, coronary artery disease are afflicting middle-aged adults an ever greater number of children globally. We planned to investigate new obesity-related factors using proteomics approaches in a randomly selected three high low BMI samples Epstein-Barr-transformed B (EBV-B) lymphoblastoid cell lines prepared from two groups young Japanese men with different...
Japanese people are widely believed to be the descendants of Jomon and Yayoi people. The dual-structure model, which attempts explain formation population, hypothesizes that indigenous migrated from northern island Hokkaido Ryukyu Islands other islands Japan, where they resided before started arrive in Kyushu (the westernmost main archipelago) Korean peninsula. Regarding Y chromosome DNA polymorphisms, it is assumed males frequently belong haplogroups C or D, while haplogroup O. These...
Heat shock transcription factor on Y (HSFY) is located in one of three candidate regions for azoospermic (AZF), AZFb the chromosome. We and others have already revealed that some males are missing chromosome including HSFY. Previously, we showed murine HSFY-like sequence [mHSFYL (Riken cDNA 4933413G11Rik)], which mouse orthologue HSFY, exclusively expressed testis. The sequences encoding presumed DNA-binding domain HSFY mHSFYL were found other mammals such as dogs, cows chickens. To...
The association between the Y chromosome haplogroup D2 and risk of azoospermia low sperm motility has been previously studied, it was indicated that haplogroups DE (YAP lineage) are associated with prostate cancer in Japanese males. Our assumption had may be sex hormone levels, because hormones have deemed responsible for spermatogenesis carcinogenesis. In this study, we assessed including those testosterone, hormone-binding globulin (SHBG), follicle-stimulating (FSH), luteinizing (LH),...
The DAZL (DAZ-like) gene is suggested to be an ancestral of the DAZ (deleted in azoospermia) on Y chromosome, which a strong candidate for azoospermic factor. Recently, it has been reported that T54A (Thr54→Ala) polymorphism exon 3 associated with spermatogenic failure Taiwanese population. In this study, investigate whether Japanese males, we analysed genomic DNA derived from 234 patients azoospermia or oligozoospermia and 131 fertile controls. was completely absent both T12A (Thr12→Ala) 2...