A5036101663- COVID-19 and Mental Health
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- Healthcare Systems and Technology
- Telemedicine and Telehealth Implementation
- Infection Control and Ventilation
- Chemical Synthesis and Analysis
- Emergency and Acute Care Studies
- SARS-CoV-2 and COVID-19 Research
- Ethics in Clinical Research
- Homelessness and Social Issues
- Cancer-related gene regulation
- Interprofessional Education and Collaboration
- Cancer Research and Treatment
- Synthesis and Characterization of Heterocyclic Compounds
- Microbial Natural Products and Biosynthesis
- Click Chemistry and Applications
- Food Security and Health in Diverse Populations
- Plant chemical constituents analysis
- Influenza Virus Research Studies
- Marine Sponges and Natural Products
- Mobile Health and mHealth Applications
- Healthcare Policy and Management
- Epigenetics and DNA Methylation
Duke University
2022-2024
Duke Institute for Health Innovation
2024
Center for Global Health
2023
Piedmont International University
2022
William & Mary
2015-2022
Williams (United States)
2015-2022
OBJECTIVES We evaluated the safety and efficacy of a test-to-stay program for unvaccinated students staff who experienced an unmasked, in-school exposure to someone with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Serial testing instead quarantine was offered asymptomatic contacts. measured secondary tertiary transmission rates within participating schools days preserved participants. METHODS Participating or from universally masked districts in North...
The Glaser–Hay coupling of terminal alkynes is a useful synthetic reaction for the preparation polyynes; however, chemoselectivity issues have precluded its widespread utilization. Conducting on solid-support provides mechanism to alleviate and provide products in high purities yields. Moreover, polyyne core key component several natural products. Herein, we describe application solid-supported These compounds were then screened antibacterial activity, illustrating utility methodology.
Correction to: Employing Unnatural Amino Acids in the Preparation of BiooconjugatesSynlett 2016; 27(06): 805-813DOI: 10.1055/s-0035-1560551
The exploitation of unnatural amino acid (UAA) technologies represents an excellent mechanism for the generation site-specific bioconjugates. Consequently, significant effort has been invested in advancement technology via integration novel bioconjugation reactions and expansion set UAAs that can be employed. Herein, we report recent developments field highlight advantages disadvantages various UAA reactions.
We evaluated the impact of a test-to-stay (TTS) program on within-school transmission and missed school days in optionally masked kindergarten through 12th grade schools during period high community severe acute respiratory syndrome coronavirus 2 transmission.
OBJECTIVES Quantify the relationship between district policy permitting in-person instruction and educational outcomes during 2020 to 2021 academic year for kindergarten through eighth grade students. METHODS An ecological, repeated cross-sectional analysis of grade-level proficiency students enrolled in public school districts North Carolina (n = 115 districts) was conducted. Univariate multivariate analyses were performed evaluate association proportion a spent end-of-year student...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) screening testing is a recommended mitigation strategy for schools, although few descriptions of program implementation are available. Methods Kindergarten through 12th grade (K–12) students and staff practicing universal masking during the delta omicron variant waves from five schools in Durham, North Carolina eight Kansas City, Missouri participated; Durham’s was structured as public health initiative...
Antibiotic resistance is a growing problem facing global societies today. Many new antibiotics are derivatized versions of already existing antibiotics, which allows for antibiotic to arise. To combat this issue, with different core structures need be elucidated. Asymmetrical polyacetylenes have been isolated from natural products and they previously demonstrated exhibit antimicrobial antibacterial activity; however, their synthetic preparation has not made them easily amenable rapid...
We collected oral and/or rectal swabs and serum from dogs cats living in homes with SARS-CoV-2-PCR-positive persons for SARS-CoV-2 PCR serology testing. Pre-COVID-19 samples were used as negative controls, tested duplicate at different timepoints. Raw ELISA results scrutinized relative to known suggested that cut-offs IgG seropositivity may require adjustment previously proposed values, while IgM more extensive validation. A small number of pet (2/43, 4.7%) one cat (1/21, 4.8%) positive RNA,...
OBJECTIVES Determine patient- and referring hospital-level predictors of transfer outcomes among children with 1 or more complex chronic conditions (CCCs) transferred to a large academic medical center. METHODS We conducted retrospective chart review 2063 pediatric inpatient admissions from 2017 2019 at least CCC defined by International Classification Diseases, Tenth Revision codes. Charts were excluded if patients admitted via any route other than hospital's emergency department ward....
Abstract Background Index-cluster studies may help characterize the spread of communicable infections in presymptomatic state. We describe a prospective index-cluster sampling strategy (ICSS) to detect respiratory viral illness and its implementation college population. Methods enrolled an annual cohort first-year undergraduates who completed daily electronic symptom diaries identify index cases (ICs) with illness. Investigators then selected 5–10 potentially exposed, asymptomatic close...
ABSTRACT BACKGROUND Test‐to‐stay (TTS) is a strategy to limit school exclusion following an exposure severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). We evaluated the use of TTS within universally masked kindergarten through 12th grade (K‐12) settings household SARS‐CoV‐2 exposure. METHODS Three hundred twenty‐two participants were enrolled. Serial rapid antigen testing was performed up 15 days post‐exposure. Analysis‐eligible completed 15‐day protocol, tested positive any time...
Protein methyltransferases are vital to the epigenetic modification of gene expression. Thus, obtaining a better understanding and control over regulation these crucial proteins has significant implications for study treatment numerous diseases. One ideal mechanism protein is specific installation photolabile-protecting group through use photocaged non-canonical amino acids. Consequently, PRMT1 was caged at key tyrosine residue with nitrobenzyl-protected Schultz acid modulate function....
OBJECTIVES To provide recommendations for future common data element (CDE) development and collection that increases community partnership, harmonizes interpretation, continues to reduce barriers of mistrust between researchers underserved communities. METHODS We conducted a cross-sectional qualitative quantitative evaluation mandatory CDE among Rapid Acceleration Diagnostics-Underserved Populations Return School project teams with various priority populations geographic locations in the...