A5100711020- Plant-based Medicinal Research
- Phytochemistry and Biological Activities
- Metabolomics and Mass Spectrometry Studies
- Natural Compounds in Disease Treatment
- Chromatography in Natural Products
- Biological and pharmacological studies of plants
- Traditional Chinese Medicine Analysis
- Berberine and alkaloids research
- Analytical Chemistry and Chromatography
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Chemical synthesis and alkaloids
- Bioactive Natural Diterpenoids Research
- Genomics, phytochemicals, and oxidative stress
- Phytochemistry and Bioactivity Studies
- Catalysis for Biomass Conversion
- Medicinal Plants and Bioactive Compounds
- Polysaccharides Composition and Applications
- Polysaccharides and Plant Cell Walls
- Cholinesterase and Neurodegenerative Diseases
- Biochemical effects in animals
- Biofield Effects and Biophysics
- Alkaloids: synthesis and pharmacology
- Ethnobotanical and Medicinal Plants Studies
- Yeasts and Rust Fungi Studies
Nanchang University
2015-2023
Fujian University of Traditional Chinese Medicine
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2021
Linyi People's Hospital
2016
Shandong University
2016
Northwest A&F University
2009
Due to numerous obstacles such as complex matrices, real-time monitoring of reaction systems (e.g., medicinal herb stewing system) has always been a challenge though great values for safe and rational use drugs. Herein, facilitated by the potential ability on tolerance matrices extractive electrospray ionization mass spectrometry, device was established realize continuous sampling quantitative analysis system first time. A complete analytical strategy, including data acquisition, mining,...
Development of rapid analytical methods and establishment toxic component limitation standards are great importance in quality control traditional Chinese medicine. Herein, an on-line extraction electrospray ionization mass spectrometry (oEESI-MS) coupled with a novel whole process integral quantification strategy was developed applied to direct determination nine key aconitine-type alkaloids 20 Aconitum proprietary medicines (APCMs). Multi-type dosage forms (e.g., tablets, capsules, pills,...
Polysaccharides are abundant in natural resources and perform numerous physiological functions. Polysaccharide structures often lack chromophore groups; thus, current analytical methods cannot distinguish polysaccharide metabolites the body or prototypes biological samples. Thus, measurement of polysaccharides blood, bodily fluid, cell-culture medium is difficult. Our early-stage research resulted isolation two homogeneous from Pseudostellaria heterophylla, PHP0.5MSC-F PHPH-1-2, which have...
Cryptomeridiol, a typical eudesmane diol, is the active principle component of antispasmodic Proximol. Although it has been used for many years, biosynthesis pathway cryptomeridiol remained blur. Among terpenoid natural products, cyclases are responsible cyclization and generation hydrocarbon backbones. The mediated by carbocationic cascades ultimately terminated via deprotonation or nucleophilic capture. Isoprene precursors are, respectively, converted into hydrocarbons hydroxylated A...
Microecology was directly or indirectly involved in the growth and development, metabolism process, component accumulation of traditional Chinese medicine(TCM) various ways, which affected formation changes geoherbalism TCM. It one main tasks medical microecology(TCMM) to reveal relationship among microecological structure its change rule quality effect The heterogeneity soil environment caused by geographical climatic factors, as well discreteness limitation isolation factors such distance...
Abstract Stripe rust, caused by Puccinia striiformis f. sp. tritici ( Pst ), is one of the most devastating wheat diseases worldwide, especially in temperate regions with cool moist weather conditions. The identification pathogen infected plants based on morphological or physiological criteria before sporulation labour‐intensive and time‐consuming. To accelerate simplify process detection, a nested Polymerase Chain Reaction (PCR) assay was developed for specific sensitive detection ....
As a bio-based platform chemical, it is desirable to convert levulinic acid (LA) varieties of value-added biochemicals. n-Butane, mainly from nonrenewable fossil resources, basic chemical produce some important chemicals, such as butadiene and ethylene. In this paper, 95.5% yield n-butane was obtained LA in one-step over base-treated Pt/C at around 300 °C 4 h. The reaction pathway confirmed be the hydrodeoxygenation valeric (VA) then VA decarboxylation by kinetic studies. Base-treated had...
Former study suggests alkaloids from herbs of Aconitum genus plants possess excellent bioactivities, which exert great value for related deeper chemical constituent investigation. Herein, isolation was performed and four were isolated Fuzi, two new ones, the other reported NMR data first time. Their structures identified by data, high resolution MS, UV IR analysis. Additionally, MS fragmentation patterns explored, formerly, that hetisane alkaloid rarely reported, mechanism diagnostic ion...
Norpimarane diterpenes possess plentiful bioactivities and are widely distributed in herbs, such as Flickingeria fimbriata. Rapid characterization of these natural products complicated plant extracts is great importance, electrospray ionization tandem mass spectrometry a powerful tool for chemical constituent profiling. However, limited researches on their fragmentation mechanisms seriously hinder identification via spectrometry.Three norpimarane isolated from F. fimbriata multiple types...
The chemical constituents of Chinese patent medicine are usually different from those crude because specific preparation processes. Chimonanthus nitens Oliv. leaf granule is widely used for prevention against COVID-19 in China. However, no research has been reported on the and their variation during process.Fragmentation patterns reference compounds were investigated using electrospray ionization mass spectrometry, new gas-phase reaction was demonstrated by electronic steric effects...
Two new and six known ent-pimaranes were isolated from Flickingeria fimbriata. One of them possesses carbon skeleton, the structure absolute configuration determined by NMR, MS, X-ray diffraction analysis. The biosynthetic pathway skeleton was proposed suggested a for these nor-ent-pimarane analogues. All compounds screened inhibitory activity against acetylcholinesterase (AChE). compound 4 exhibits potent effect on AChE with 50% concentration (IC50) being 5.8 μM, which is close to that...
Coumarins and flavonoids are important aromatic natural compounds widely distributed in medicinal plants. Most of them possess diverse bioactivities mainly bioactive material foundation. However, the fragmentation patterns investigation under electrospray ion source mass is still ongoing rapid chemical structure identification by tandem remains to be trapped functional group assignment. Herein, 12 reference were intensely examined establish broken mechanisms. Calculation chemistry virtual...